FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288046315> ?p ?o ?g. }

• W4288046315 endingPage "114737" @default.
• W4288046315 startingPage "114737" @default.
• W4288046315 abstract "Primary negative symptoms of schizophrenia are usually resistant to monotherapy with antipsychotics. The present study sought to assess the efficacy and tolerability of Palmitoylethanolamide (PEA) adjunctive therapy in treatment of negative symptoms in patients with stable schizophrenia.This 8-week (trial timepoints: baseline, week 4, week 8), double-blind, placebo-controlled clinical trial randomized patients with schizophrenia in a 1:1 ratio to compare the efficacy and safety of 600 mg twice a day of PEA and matched placebo alongside a stable dose of risperidone. Outcome measures were the positive and the negative syndrome scale (PANSS), the extrapyramidal symptom rating scale (ESRS), and the Hamilton depression rating scale (HDRS). The primary outcome was change in the negative subscale score during the trial period between the groups. Safety of interventions were controlled and addressed during the trial.A total of 50 participants completed the trial (25 in each group). Baseline characteristics of the groups were comparable (p>0.05). There was significant effect from time-treatment interaction on negative symptoms (p = 0.012) suggesting greater symptom improvement in the PEA group. In contrast, the longitudinal changes in positive symptoms and depressive symptoms were similar between groups (p values>0.05). Safety assessments showed no significant difference regarding extrapyramidal symptoms, measured by ESRS, and also frequency of other complications between PEA and placebo groups (p values>0.05).Adjunctive therapy with PEA and risperidone alleviates schizophrenia-related primary negative symptoms in a safe manner." @default.
• W4288046315 created "2022-07-27" @default.
• W4288046315 creator A5012500635 @default.
• W4288046315 creator A5025427272 @default.
• W4288046315 creator A5032789278 @default.
• W4288046315 creator A5046823287 @default.
• W4288046315 creator A5081859146 @default.
• W4288046315 creator A5086914915 @default.
• W4288046315 creator A5088810181 @default.
• W4288046315 date "2022-10-01" @default.
• W4288046315 modified "2023-10-17" @default.
• W4288046315 title "Adjuvant palmitoylethanolamide therapy with risperidone improves negative symptoms in patients with schizophrenia: A randomized, double-blinded, placebo-controlled trial" @default.
• W4288046315 cites W153750880 @default.
• W4288046315 cites W1963580478 @default.
• W4288046315 cites W1968917850 @default.
• W4288046315 cites W1970391423 @default.
• W4288046315 cites W1972730748 @default.
• W4288046315 cites W1982058167 @default.
• W4288046315 cites W1985401089 @default.
• W4288046315 cites W1993562858 @default.
• W4288046315 cites W2001297634 @default.
• W4288046315 cites W2011534445 @default.
• W4288046315 cites W2020825180 @default.
• W4288046315 cites W2021337250 @default.
• W4288046315 cites W2024554713 @default.
• W4288046315 cites W2028247915 @default.
• W4288046315 cites W2035477056 @default.
• W4288046315 cites W2042295716 @default.
• W4288046315 cites W2055615777 @default.
• W4288046315 cites W2062367858 @default.
• W4288046315 cites W2072661735 @default.
• W4288046315 cites W2089545943 @default.
• W4288046315 cites W2091751785 @default.
• W4288046315 cites W2095627308 @default.
• W4288046315 cites W2100371827 @default.
• W4288046315 cites W2104255009 @default.
• W4288046315 cites W2106156723 @default.
• W4288046315 cites W2114613490 @default.
• W4288046315 cites W2117296341 @default.
• W4288046315 cites W2119605567 @default.
• W4288046315 cites W2127819913 @default.
• W4288046315 cites W2138685334 @default.
• W4288046315 cites W2140606211 @default.
• W4288046315 cites W2147780949 @default.
• W4288046315 cites W2169269177 @default.
• W4288046315 cites W2246287213 @default.
• W4288046315 cites W2289578198 @default.
• W4288046315 cites W2329963239 @default.
• W4288046315 cites W2331141065 @default.
• W4288046315 cites W2400751176 @default.
• W4288046315 cites W2462451779 @default.
• W4288046315 cites W2585578522 @default.
• W4288046315 cites W2625024332 @default.
• W4288046315 cites W2766462984 @default.
• W4288046315 cites W2789850091 @default.
• W4288046315 cites W2790631595 @default.
• W4288046315 cites W2790867816 @default.
• W4288046315 cites W2801116518 @default.
• W4288046315 cites W2801704870 @default.
• W4288046315 cites W2883804296 @default.
• W4288046315 cites W2886046928 @default.
• W4288046315 cites W2888342366 @default.
• W4288046315 cites W2906768105 @default.
• W4288046315 cites W2913588197 @default.
• W4288046315 cites W2982685163 @default.
• W4288046315 cites W3006980700 @default.
• W4288046315 cites W3007830452 @default.
• W4288046315 cites W3082177965 @default.
• W4288046315 cites W3097943335 @default.
• W4288046315 cites W3112946999 @default.
• W4288046315 cites W3123684028 @default.
• W4288046315 cites W3169140981 @default.
• W4288046315 cites W4292528167 @default.
• W4288046315 cites W45776812 @default.
• W4288046315 doi "https://doi.org/10.1016/j.psychres.2022.114737" @default.
• W4288046315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35917650" @default.
• W4288046315 hasPublicationYear "2022" @default.
• W4288046315 type Work @default.
• W4288046315 citedByCount "6" @default.
• W4288046315 countsByYear W42880463152022 @default.
• W4288046315 countsByYear W42880463152023 @default.
• W4288046315 crossrefType "journal-article" @default.
• W4288046315 hasAuthorship W4288046315A5012500635 @default.
• W4288046315 hasAuthorship W4288046315A5025427272 @default.
• W4288046315 hasAuthorship W4288046315A5032789278 @default.
• W4288046315 hasAuthorship W4288046315A5046823287 @default.
• W4288046315 hasAuthorship W4288046315A5081859146 @default.
• W4288046315 hasAuthorship W4288046315A5086914915 @default.
• W4288046315 hasAuthorship W4288046315A5088810181 @default.
• W4288046315 hasConcept C118552586 @default.
• W4288046315 hasConcept C126322002 @default.
• W4288046315 hasConcept C142724271 @default.
• W4288046315 hasConcept C168563851 @default.
• W4288046315 hasConcept C197934379 @default.
• W4288046315 hasConcept C204787440 @default.
• W4288046315 hasConcept C27081682 @default.
• W4288046315 hasConcept C2776412080 @default.
• W4288046315 hasConcept C2778375690 @default.

• next