FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288049706> ?p ?o ?g. }

• W4288049706 endingPage "1266" @default.
• W4288049706 startingPage "1259" @default.
• W4288049706 abstract "Long-term peritoneal dialysis is associated with alterations in peritoneal function, like the development of high small solute transfer rates and impaired ultrafiltration. Also, morphologic changes can develop, the most prominent being loss of mesothelium, vasculopathy, and interstitial fibrosis. Current research suggests peritoneal inflammation as the driving force for these alterations. In this review, the available evidence for inflammation is examined and a new hypothesis is put forward consisting of high glucose-induced pseudohypoxia. Hypoxia of cells is characterized by a high (oxidized-reduced nicotinamide dinucleotide ratio) NADH-NAD + ratio in their cytosol. Pseudohypoxia is similar but occurs when excessive amounts of glucose are metabolized, as is the case for peritoneal interstitial cells in peritoneal dialysis. The glucose-induced high NADH-NAD + ratio upregulates the hypoxia-inducible factor-1 gene, which stimulates not only the glucose transporter-1 gene but also many profibrotic genes like TGF β , vascular endothelial growth factor, plasminogen activator inhibitor-1, and connective tissue growth factor, all known to be involved in the development of peritoneal fibrosis. This review discusses the causes and consequences of pseudohypoxia in peritoneal dialysis and the available options for treatment and prevention. Reducing peritoneal exposure to the excessively high dialysate glucose load is the cornerstone to avoid the pseudohypoxia-induced alterations. This can partly be done by the use of icodextrin or by combinations of low molecular mass osmotic agents, all in a low dose. The addition of alanyl-glutamine to the dialysis solution needs further clinical investigation." @default.
• W4288049706 created "2022-07-27" @default.
• W4288049706 creator A5028637235 @default.
• W4288049706 creator A5045187712 @default.
• W4288049706 date "2022-08-01" @default.
• W4288049706 modified "2023-10-04" @default.
• W4288049706 title "Relative Contributions of Pseudohypoxia and Inflammation to Peritoneal Alterations with Long-Term Peritoneal Dialysis Patients" @default.
• W4288049706 cites W1850344898 @default.
• W4288049706 cites W1956486503 @default.
• W4288049706 cites W1969494858 @default.
• W4288049706 cites W1979761267 @default.
• W4288049706 cites W1990392175 @default.
• W4288049706 cites W1993893385 @default.
• W4288049706 cites W1996970711 @default.
• W4288049706 cites W2019695205 @default.
• W4288049706 cites W2020969996 @default.
• W4288049706 cites W2021409462 @default.
• W4288049706 cites W2021411033 @default.
• W4288049706 cites W2028615837 @default.
• W4288049706 cites W2035175400 @default.
• W4288049706 cites W2036043156 @default.
• W4288049706 cites W2041206609 @default.
• W4288049706 cites W2094539346 @default.
• W4288049706 cites W2105621799 @default.
• W4288049706 cites W2112850039 @default.
• W4288049706 cites W2114605107 @default.
• W4288049706 cites W2115491982 @default.
• W4288049706 cites W2118254829 @default.
• W4288049706 cites W2122981222 @default.
• W4288049706 cites W2125269447 @default.
• W4288049706 cites W2127231698 @default.
• W4288049706 cites W2128578138 @default.
• W4288049706 cites W2128597516 @default.
• W4288049706 cites W2135559148 @default.
• W4288049706 cites W2145709491 @default.
• W4288049706 cites W2145913649 @default.
• W4288049706 cites W2159788200 @default.
• W4288049706 cites W2161283881 @default.
• W4288049706 cites W2161808245 @default.
• W4288049706 cites W2165265744 @default.
• W4288049706 cites W2169061609 @default.
• W4288049706 cites W2169164897 @default.
• W4288049706 cites W2170251481 @default.
• W4288049706 cites W2181833106 @default.
• W4288049706 cites W2197521232 @default.
• W4288049706 cites W2267248673 @default.
• W4288049706 cites W2271740119 @default.
• W4288049706 cites W2324841714 @default.
• W4288049706 cites W2335187016 @default.
• W4288049706 cites W2460105090 @default.
• W4288049706 cites W2510362766 @default.
• W4288049706 cites W2579804224 @default.
• W4288049706 cites W2592535610 @default.
• W4288049706 cites W2616222401 @default.
• W4288049706 cites W2751635377 @default.
• W4288049706 cites W2789892633 @default.
• W4288049706 cites W2795831303 @default.
• W4288049706 cites W2803228169 @default.
• W4288049706 cites W2889689531 @default.
• W4288049706 cites W2895894869 @default.
• W4288049706 cites W2906180866 @default.
• W4288049706 cites W2912194108 @default.
• W4288049706 cites W2932455415 @default.
• W4288049706 cites W2981350175 @default.
• W4288049706 cites W2990179706 @default.
• W4288049706 cites W3002803740 @default.
• W4288049706 cites W3098314043 @default.
• W4288049706 cites W3175918990 @default.
• W4288049706 cites W3184389079 @default.
• W4288049706 cites W4241257789 @default.
• W4288049706 cites W4247441207 @default.
• W4288049706 doi "https://doi.org/10.2215/cjn.15371121" @default.
• W4288049706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35168992" @default.
• W4288049706 hasPublicationYear "2022" @default.
• W4288049706 type Work @default.
• W4288049706 citedByCount "9" @default.
• W4288049706 countsByYear W42880497062022 @default.
• W4288049706 countsByYear W42880497062023 @default.
• W4288049706 crossrefType "journal-article" @default.
• W4288049706 hasAuthorship W4288049706A5028637235 @default.
• W4288049706 hasAuthorship W4288049706A5045187712 @default.
• W4288049706 hasBestOaLocation W42880497061 @default.
• W4288049706 hasConcept C126322002 @default.
• W4288049706 hasConcept C134018914 @default.
• W4288049706 hasConcept C142724271 @default.
• W4288049706 hasConcept C2776001837 @default.
• W4288049706 hasConcept C2776914184 @default.
• W4288049706 hasConcept C2779056158 @default.
• W4288049706 hasConcept C2780559512 @default.
• W4288049706 hasConcept C71924100 @default.
• W4288049706 hasConceptScore W4288049706C126322002 @default.
• W4288049706 hasConceptScore W4288049706C134018914 @default.
• W4288049706 hasConceptScore W4288049706C142724271 @default.
• W4288049706 hasConceptScore W4288049706C2776001837 @default.
• W4288049706 hasConceptScore W4288049706C2776914184 @default.
• W4288049706 hasConceptScore W4288049706C2779056158 @default.
• W4288049706 hasConceptScore W4288049706C2780559512 @default.
• W4288049706 hasConceptScore W4288049706C71924100 @default.

• next