Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288051104> ?p ?o ?g. }
- W4288051104 abstract "Abstract Endometrial health is affected by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor α (ESR1) cistromes and transcriptomes of endometrial biopsies taken from the proliferative and mid-secretory phases of the menstrual cycle together with hormonally stimulated endometrial epithelial organoids. The cycle stage–specific ESR1 binding sites were determined by chromatin immunoprecipitation and next-generation sequencing and then integrated with changes in gene expression from RNA sequencing data to infer candidate ESR1 targets in normal endometrium. Genes with ESR1 binding in whole endometrium were enriched for chromatin modification and regulation of cell proliferation. The distribution of ESR1 binding sites in organoids was more distal from gene promoters when compared to primary endometrium and was more similar to the proliferative than the mid-secretory phase ESR1 cistrome. Inferred organoid estrogen/ESR1 candidate target genes affected formation of cellular protrusions and chromatin modification. Comparison of signaling effected by candidate ESR1 target genes in endometrium vs organoids reveals enrichment of both overlapping and distinct responses. Our analysis of the ESR1 cistromes and transcriptomes from endometrium and organoids provides important resources for understanding how estrogen affects endometrial health and function." @default.
- W4288051104 created "2022-07-28" @default.
- W4288051104 creator A5033939847 @default.
- W4288051104 creator A5034900321 @default.
- W4288051104 creator A5061177890 @default.
- W4288051104 creator A5066908162 @default.
- W4288051104 creator A5069048623 @default.
- W4288051104 creator A5076315257 @default.
- W4288051104 creator A5077909338 @default.
- W4288051104 creator A5090642212 @default.
- W4288051104 creator A5090686062 @default.
- W4288051104 date "2022-07-27" @default.
- W4288051104 modified "2023-10-14" @default.
- W4288051104 title "The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids" @default.
- W4288051104 cites W1565532031 @default.
- W4288051104 cites W1965088114 @default.
- W4288051104 cites W1966922385 @default.
- W4288051104 cites W1994439119 @default.
- W4288051104 cites W1996814033 @default.
- W4288051104 cites W1997954319 @default.
- W4288051104 cites W2006494078 @default.
- W4288051104 cites W2014091868 @default.
- W4288051104 cites W2014677321 @default.
- W4288051104 cites W2018621705 @default.
- W4288051104 cites W2021713357 @default.
- W4288051104 cites W2024148591 @default.
- W4288051104 cites W2034121537 @default.
- W4288051104 cites W2045273474 @default.
- W4288051104 cites W2048533734 @default.
- W4288051104 cites W2051150230 @default.
- W4288051104 cites W2055139693 @default.
- W4288051104 cites W2059153388 @default.
- W4288051104 cites W2065756417 @default.
- W4288051104 cites W2074191436 @default.
- W4288051104 cites W2093350076 @default.
- W4288051104 cites W2094127713 @default.
- W4288051104 cites W2097065948 @default.
- W4288051104 cites W2097327255 @default.
- W4288051104 cites W2111637996 @default.
- W4288051104 cites W2117089877 @default.
- W4288051104 cites W2122097157 @default.
- W4288051104 cites W2123274316 @default.
- W4288051104 cites W2124985265 @default.
- W4288051104 cites W2143980775 @default.
- W4288051104 cites W2145926321 @default.
- W4288051104 cites W2146573461 @default.
- W4288051104 cites W2151995538 @default.
- W4288051104 cites W2153523244 @default.
- W4288051104 cites W2167383223 @default.
- W4288051104 cites W2171808845 @default.
- W4288051104 cites W2173213419 @default.
- W4288051104 cites W2298612765 @default.
- W4288051104 cites W2367905128 @default.
- W4288051104 cites W2417975620 @default.
- W4288051104 cites W2492850618 @default.
- W4288051104 cites W2536816604 @default.
- W4288051104 cites W2586868780 @default.
- W4288051104 cites W2606864355 @default.
- W4288051104 cites W2615963669 @default.
- W4288051104 cites W2622857043 @default.
- W4288051104 cites W2623782972 @default.
- W4288051104 cites W2725559674 @default.
- W4288051104 cites W2754504590 @default.
- W4288051104 cites W2760114054 @default.
- W4288051104 cites W2775401938 @default.
- W4288051104 cites W2795022994 @default.
- W4288051104 cites W2808538861 @default.
- W4288051104 cites W2896581632 @default.
- W4288051104 cites W2900484561 @default.
- W4288051104 cites W2902733816 @default.
- W4288051104 cites W2906903289 @default.
- W4288051104 cites W2913100284 @default.
- W4288051104 cites W2944728655 @default.
- W4288051104 cites W2945695834 @default.
- W4288051104 cites W2949405870 @default.
- W4288051104 cites W2958037602 @default.
- W4288051104 cites W2965589450 @default.
- W4288051104 cites W2966343206 @default.
- W4288051104 cites W2982312837 @default.
- W4288051104 cites W2982386449 @default.
- W4288051104 cites W3015058708 @default.
- W4288051104 cites W3016339115 @default.
- W4288051104 cites W3021367274 @default.
- W4288051104 cites W3026122184 @default.
- W4288051104 cites W3081589695 @default.
- W4288051104 cites W3083227622 @default.
- W4288051104 cites W3089191828 @default.
- W4288051104 cites W3095642234 @default.
- W4288051104 cites W3110220149 @default.
- W4288051104 cites W3114206138 @default.
- W4288051104 cites W3155433639 @default.
- W4288051104 cites W3164031073 @default.
- W4288051104 cites W3183849717 @default.
- W4288051104 cites W3202817642 @default.
- W4288051104 cites W3213749060 @default.
- W4288051104 cites W3214755680 @default.
- W4288051104 cites W4206326996 @default.
- W4288051104 cites W4210910283 @default.
- W4288051104 cites W4250290055 @default.
- W4288051104 cites W4254976707 @default.