Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288052108> ?p ?o ?g. }
- W4288052108 abstract "T regulatory (Treg) cells are essential for self-tolerance whereas they are detrimental for dampening the host anti-tumor immunity. How Treg cells adapt to environmental signals to orchestrate their homeostasis and functions remains poorly understood. Here, we identified that transcription factor EB (TFEB) is induced by host nutrition deprivation or interleukin (IL)-2 in CD4+ T cells. The loss of TFEB in Treg cells leads to reduced Treg accumulation and impaired Treg function in mouse models of cancer and autoimmune disease. TFEB intrinsically regulates genes involved in Treg cell differentiation and mitochondria function while it suppresses expression of proinflammatory cytokines independently of its established roles in autophagy. This coordinated action is required for mitochondria integrity and appropriate lipid metabolism in Treg cells. These findings identify TFEB as a critical regulator for orchestrating Treg generation and function, which may contribute to the adaptive responses of T cells to local environmental cues." @default.
- W4288052108 created "2022-07-28" @default.
- W4288052108 creator A5003573240 @default.
- W4288052108 creator A5003733739 @default.
- W4288052108 creator A5004003909 @default.
- W4288052108 creator A5018371071 @default.
- W4288052108 creator A5020497057 @default.
- W4288052108 creator A5022217280 @default.
- W4288052108 creator A5023363049 @default.
- W4288052108 creator A5028957709 @default.
- W4288052108 creator A5037078581 @default.
- W4288052108 creator A5037677450 @default.
- W4288052108 creator A5048815633 @default.
- W4288052108 creator A5052052518 @default.
- W4288052108 creator A5055508981 @default.
- W4288052108 creator A5056221361 @default.
- W4288052108 creator A5058017510 @default.
- W4288052108 creator A5066871070 @default.
- W4288052108 creator A5066934859 @default.
- W4288052108 creator A5080646236 @default.
- W4288052108 creator A5086400683 @default.
- W4288052108 creator A5089639451 @default.
- W4288052108 date "2022-07-27" @default.
- W4288052108 modified "2023-09-28" @default.
- W4288052108 title "Transcription factor EB coordinates environmental cues to regulate T regulatory cells’ mitochondrial fitness and function" @default.
- W4288052108 cites W1580723613 @default.
- W4288052108 cites W1878828051 @default.
- W4288052108 cites W1965671023 @default.
- W4288052108 cites W1975200363 @default.
- W4288052108 cites W1982696151 @default.
- W4288052108 cites W1992662011 @default.
- W4288052108 cites W2023363164 @default.
- W4288052108 cites W2056721231 @default.
- W4288052108 cites W2061561904 @default.
- W4288052108 cites W2063920469 @default.
- W4288052108 cites W2068639447 @default.
- W4288052108 cites W2070658923 @default.
- W4288052108 cites W2073672027 @default.
- W4288052108 cites W2078184757 @default.
- W4288052108 cites W2087998194 @default.
- W4288052108 cites W2124411878 @default.
- W4288052108 cites W2124966133 @default.
- W4288052108 cites W2132552158 @default.
- W4288052108 cites W2139948451 @default.
- W4288052108 cites W2141649011 @default.
- W4288052108 cites W2157739158 @default.
- W4288052108 cites W2243760265 @default.
- W4288052108 cites W2263577129 @default.
- W4288052108 cites W2281605325 @default.
- W4288052108 cites W2387356591 @default.
- W4288052108 cites W2419601133 @default.
- W4288052108 cites W2512028013 @default.
- W4288052108 cites W2565398910 @default.
- W4288052108 cites W2611694282 @default.
- W4288052108 cites W2803875384 @default.
- W4288052108 cites W2810583651 @default.
- W4288052108 cites W2810786508 @default.
- W4288052108 cites W2895487889 @default.
- W4288052108 cites W2949603991 @default.
- W4288052108 cites W2973293314 @default.
- W4288052108 cites W2997024483 @default.
- W4288052108 cites W3005483243 @default.
- W4288052108 cites W3040651070 @default.
- W4288052108 cites W3133105567 @default.
- W4288052108 cites W4244124467 @default.
- W4288052108 doi "https://doi.org/10.1073/pnas.2205469119" @default.
- W4288052108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35895684" @default.
- W4288052108 hasPublicationYear "2022" @default.
- W4288052108 type Work @default.
- W4288052108 citedByCount "5" @default.
- W4288052108 countsByYear W42880521082022 @default.
- W4288052108 countsByYear W42880521082023 @default.
- W4288052108 crossrefType "journal-article" @default.
- W4288052108 hasAuthorship W4288052108A5003573240 @default.
- W4288052108 hasAuthorship W4288052108A5003733739 @default.
- W4288052108 hasAuthorship W4288052108A5004003909 @default.
- W4288052108 hasAuthorship W4288052108A5018371071 @default.
- W4288052108 hasAuthorship W4288052108A5020497057 @default.
- W4288052108 hasAuthorship W4288052108A5022217280 @default.
- W4288052108 hasAuthorship W4288052108A5023363049 @default.
- W4288052108 hasAuthorship W4288052108A5028957709 @default.
- W4288052108 hasAuthorship W4288052108A5037078581 @default.
- W4288052108 hasAuthorship W4288052108A5037677450 @default.
- W4288052108 hasAuthorship W4288052108A5048815633 @default.
- W4288052108 hasAuthorship W4288052108A5052052518 @default.
- W4288052108 hasAuthorship W4288052108A5055508981 @default.
- W4288052108 hasAuthorship W4288052108A5056221361 @default.
- W4288052108 hasAuthorship W4288052108A5058017510 @default.
- W4288052108 hasAuthorship W4288052108A5066871070 @default.
- W4288052108 hasAuthorship W4288052108A5066934859 @default.
- W4288052108 hasAuthorship W4288052108A5080646236 @default.
- W4288052108 hasAuthorship W4288052108A5086400683 @default.
- W4288052108 hasAuthorship W4288052108A5089639451 @default.
- W4288052108 hasBestOaLocation W42880521081 @default.
- W4288052108 hasConcept C104317684 @default.
- W4288052108 hasConcept C132647116 @default.
- W4288052108 hasConcept C14036430 @default.
- W4288052108 hasConcept C190283241 @default.
- W4288052108 hasConcept C203014093 @default.
- W4288052108 hasConcept C203522944 @default.