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- W4288052111 abstract "Abstract Almost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the significance of cilia, once considered vestigial organelles, in the higher-order brain functions is unknown. Cilia act as a hub that senses and transduces environmental sensory stimuli to generate an appropriate cellular response. Similarly, the striatum, a brain structure enriched in cilia, functions as a hub that receives and integrates various types of environmental information to drive appropriate motor response. To understand cilia's role in the striatum functions, we used loxP/Cre technology to ablate cilia from the dorsal striatum and monitored the behavioral consequences. Our results revealed an essential role for striatal cilia in the acquisition of and brief storage of information, including learning new motor skills, but not in long-term consolidation of information or maintaining habitual/learned motor skills. A fundamental aspect of all disrupted functions was the time perception/judgment deficit, indicating a critical role for striatal cilia in brain central clock function. Further, the observed behavioral deficits form a set/cluster pertaining to clinical manifestations overlapping across disorders involving the striatum functions and to exhibit timing deficits, including attention-deficit hyperactivity disorder, Huntington's disease, Parkinson's disease, schizophrenia, autism spectrum disorder, Tourette syndrome, and obsessive-compulsive disorder. Thus, striatal cilia may act as a calibrator of the basal ganglia-cortical circuit clock functions by maintaining proper timing perception. Accordingly, dysfunctional cilia might be a unifying factor that contributes to the pathophysiology of neuro-psychiatric disorders, as related to deficits in timing tasks performance, and may serve as therapeutic targets for these disorders." @default.
- W4288052111 created "2022-07-28" @default.
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- W4288052111 date "2022-07-27" @default.
- W4288052111 modified "2023-09-28" @default.
- W4288052111 title "Cilia in the Striatum Mediate Timing-Dependent Functions: Implications for Neuro-Psychiatric Disorders" @default.
- W4288052111 doi "https://doi.org/10.21203/rs.3.rs-1804396/v1" @default.
- W4288052111 hasPublicationYear "2022" @default.
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