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- W4288052149 abstract "Abstract Chronic adversity in early childhood is associated with increased anxiety and a propensity for substance abuse later in adulthood, yet the effects of early life stress (ELS) on brain development remain poorly understood. The zebrafish, Danio rerio , is a powerful model for studying neurodevelopment and stress. Here, we describe a zebrafish model of ELS and identify a role for glucocorticoid signaling during a critical window in development that leads to long-term changes in brain function. Larval fish subjected to chronic stress in early development exhibited increased anxiety-like behavior and elevated glucocorticoid levels later in life. Increased stress-like behavior was only observed when fish were subjected to ELS within a precise time window in early development, revealing a temporal critical window of sensitivity. Moreover, enhanced anxiety-like behavior only emerges after two months post-ELS, revealing a developmentally specified delay in the effects of ELS. ELS leads to increased levels of baseline cortisol, and resulted in a dysregulation of cortisol receptors’ mRNA expression, suggesting long-term effects on cortisol signaling. Together, these findings reveal a ‘critical window’ for ELS to affect developmental reprogramming of the glucocorticoid receptor pathway, resulting in chronic elevated stress." @default.
- W4288052149 created "2022-07-28" @default.
- W4288052149 creator A5010723016 @default.
- W4288052149 creator A5010898773 @default.
- W4288052149 creator A5029765045 @default.
- W4288052149 creator A5041865755 @default.
- W4288052149 creator A5082478232 @default.
- W4288052149 date "2022-07-27" @default.
- W4288052149 modified "2023-09-25" @default.
- W4288052149 title "Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish" @default.
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