FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288056265> ?p ?o ?g. }

• W4288056265 endingPage "3267" @default.
• W4288056265 startingPage "3251" @default.
• W4288056265 abstract "Mycophenolate mofetil (MMF), for which the bioactive metabolite is mycophenolic acid (MPA), is a frequently used immunosuppressant for systemic lupus erythematosus (SLE). However, its short half-life and poor biodistribution into cells and tissues hinder its clinical efficacy. Our dextran mycophenolate-based nanoparticles (MPA@Dex-MPA NPs) have greatly improved the pharmacokinetics of MMF/MPA. We here tested the therapeutic efficacy of MPA@Dex-MPA NPs against SLE and investigated the underlying mechanism.The tissue and immune cell biodistributions of MPA@Dex-MPA NPs were traced using live fluorescence imaging system and flow cytometry, respectively. Serological proinflammatory mediators and kidney damage were detected to assess the efficacy of MPA@Dex-MPA NPs treatments of MRL/lpr lupus-prone mice. Immune cell changes in the kidney and spleen were further analyzed post-treatment via flow cytometry. Bone marrow-derived macrophages were used to investigate the potential mechanism.MPA@Dex-MPA NPs exhibited superior therapeutic efficacy and safety in the MRL/lpr mice using significantly lower administration dosage (one-fifth) and frequency (once/3 days) compared to MMF/MPA used in ordinary practice. The overall prognosis of the mice was improved as they showed lower levels of serological proinflammatory mediators. Moreover, kidney injury was alleviated with reduced pathological signs and decreased urine protein-creatinine ratio. Further investigations of the underlying mechanism revealed a preferential penetration and persistent retention of MPA@Dex-MPA NPs in the spleen and kidney, where they were mostly phagocytosed by macrophages. The macrophages were found to be polarized towards a CD206+ M2-like phenotype, with a downregulation of surface CD80 and CD40, and reduced TNF-α production in the spleen and kidney and in vitro. The expansion of T cells was also significantly inhibited in these two organs.Our research improved the efficacy of MPA for MRL/lpr mice through synthesizing MPA@Dex-MPA NPs to enhance its tissue biodistribution and explored the possible mechanism, providing a promising strategy for SLE therapy." @default.
• W4288056265 created "2022-07-28" @default.
• W4288056265 creator A5006573531 @default.
• W4288056265 creator A5010731953 @default.
• W4288056265 creator A5031540971 @default.
• W4288056265 creator A5034840876 @default.
• W4288056265 creator A5035544360 @default.
• W4288056265 creator A5037506720 @default.
• W4288056265 creator A5040479834 @default.
• W4288056265 creator A5051567318 @default.
• W4288056265 creator A5056631481 @default.
• W4288056265 creator A5061223537 @default.
• W4288056265 creator A5070004746 @default.
• W4288056265 creator A5077072862 @default.
• W4288056265 creator A5077245707 @default.
• W4288056265 creator A5086038672 @default.
• W4288056265 date "2022-07-01" @default.
• W4288056265 modified "2023-09-26" @default.
• W4288056265 title "A Tissue-Tended Mycophenolate-Modified Nanoparticle Alleviates Systemic Lupus Erythematosus in MRL/Lpr Mouse Model Mainly by Promoting Local M2-Like Macrophagocytes Polarization" @default.
• W4288056265 cites W1556210341 @default.
• W4288056265 cites W1918150899 @default.
• W4288056265 cites W2051742762 @default.
• W4288056265 cites W2059121698 @default.
• W4288056265 cites W2083409993 @default.
• W4288056265 cites W2108813495 @default.
• W4288056265 cites W2278639759 @default.
• W4288056265 cites W2498230230 @default.
• W4288056265 cites W2579899277 @default.
• W4288056265 cites W2615235559 @default.
• W4288056265 cites W2625419804 @default.
• W4288056265 cites W2751184724 @default.
• W4288056265 cites W2779178535 @default.
• W4288056265 cites W2790138041 @default.
• W4288056265 cites W2792564419 @default.
• W4288056265 cites W2794030130 @default.
• W4288056265 cites W2811212765 @default.
• W4288056265 cites W2811251201 @default.
• W4288056265 cites W2912791320 @default.
• W4288056265 cites W2914604590 @default.
• W4288056265 cites W2917284290 @default.
• W4288056265 cites W2927871970 @default.
• W4288056265 cites W2948946994 @default.
• W4288056265 cites W2955268051 @default.
• W4288056265 cites W2967301016 @default.
• W4288056265 cites W2972587564 @default.
• W4288056265 cites W2973061408 @default.
• W4288056265 cites W2996276729 @default.
• W4288056265 cites W2997747472 @default.
• W4288056265 cites W3006443568 @default.
• W4288056265 cites W3012553260 @default.
• W4288056265 cites W3013081823 @default.
• W4288056265 cites W3022548816 @default.
• W4288056265 cites W3023267770 @default.
• W4288056265 cites W3033330880 @default.
• W4288056265 cites W3037530918 @default.
• W4288056265 cites W3089295303 @default.
• W4288056265 cites W3092289522 @default.
• W4288056265 cites W3092324881 @default.
• W4288056265 cites W3126358774 @default.
• W4288056265 cites W3131637462 @default.
• W4288056265 cites W3133342742 @default.
• W4288056265 cites W4211168185 @default.
• W4288056265 cites W4231495302 @default.
• W4288056265 doi "https://doi.org/10.2147/ijn.s361400" @default.
• W4288056265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35924257" @default.
• W4288056265 hasPublicationYear "2022" @default.
• W4288056265 type Work @default.
• W4288056265 citedByCount "4" @default.
• W4288056265 countsByYear W42880562652023 @default.
• W4288056265 crossrefType "journal-article" @default.
• W4288056265 hasAuthorship W4288056265A5006573531 @default.
• W4288056265 hasAuthorship W4288056265A5010731953 @default.
• W4288056265 hasAuthorship W4288056265A5031540971 @default.
• W4288056265 hasAuthorship W4288056265A5034840876 @default.
• W4288056265 hasAuthorship W4288056265A5035544360 @default.
• W4288056265 hasAuthorship W4288056265A5037506720 @default.
• W4288056265 hasAuthorship W4288056265A5040479834 @default.
• W4288056265 hasAuthorship W4288056265A5051567318 @default.
• W4288056265 hasAuthorship W4288056265A5056631481 @default.
• W4288056265 hasAuthorship W4288056265A5061223537 @default.
• W4288056265 hasAuthorship W4288056265A5070004746 @default.
• W4288056265 hasAuthorship W4288056265A5077072862 @default.
• W4288056265 hasAuthorship W4288056265A5077245707 @default.
• W4288056265 hasAuthorship W4288056265A5086038672 @default.
• W4288056265 hasBestOaLocation W42880562651 @default.
• W4288056265 hasConcept C126322002 @default.
• W4288056265 hasConcept C142724271 @default.
• W4288056265 hasConcept C164027704 @default.
• W4288056265 hasConcept C185592680 @default.
• W4288056265 hasConcept C19702531 @default.
• W4288056265 hasConcept C202751555 @default.
• W4288056265 hasConcept C203014093 @default.
• W4288056265 hasConcept C2776912625 @default.
• W4288056265 hasConcept C2776914184 @default.
• W4288056265 hasConcept C2777807558 @default.
• W4288056265 hasConcept C2778033501 @default.
• W4288056265 hasConcept C2779134260 @default.
• W4288056265 hasConcept C2780091579 @default.

• next