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- W4288068574 abstract "Podosomes are actin-enriched adhesion structures important for multiple cellular processes, including migration, bone remodeling, and phagocytosis. Here, we characterize the structure and organization of phagocytic podosomes using interferometric photoactivated localization microscopy, a super-resolution microscopy technique capable of 15-20 nm resolution, together with structured illumination microscopy and localization-based super-resolution microscopy. Phagocytic podosomes are observed during frustrated phagocytosis, a model in which cells attempt to engulf micropatterned IgG antibodies. For circular patterns, this results in regular arrays of podosomes with well-defined geometry. Using persistent homology, we develop a pipeline for semi-automatic identification and measurement of podosome features. These studies reveal an hourglass shape of the podosome actin core, a protruding knob at the bottom of the core, and two actin networks extending from the core. Additionally, the distributions of paxillin, talin, myosin II, α-actinin, cortactin, and microtubules relative to actin are characterized." @default.
- W4288068574 created "2022-07-28" @default.
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- W4288068574 date "2022-07-27" @default.
- W4288068574 modified "2023-10-14" @default.
- W4288068574 title "Actin nano-architecture of phagocytic podosomes" @default.
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- W4288068574 doi "https://doi.org/10.1038/s41467-022-32038-0" @default.
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