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• W4288068583 abstract "Objective Amyotrophic lateral sclerosis (ALS) pathogenesis is still unclear, its course is considerably variable, and prognosis is hard to determine. Despite much research, there is still a lack of easily accessible markers predicting prognosis. We investigated routine blood parameters in ALS patients regarding correlations with disease severity, progression rate, and survival. Additionally, we analyzed disease and patients' characteristics relating to baseline blood parameter levels. Methods We analyzed creatine kinase (CK), albumin (ALB), creatinine (CREA), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) levels around time of diagnosis in 1,084 ALS patients. We carried out linear regression analyses including disease and patients' characteristics with each blood parameter to detect correlations with them. Linear regression models were performed for ALSFRS-R at study entry, its retrospectively defined rate of decay and prospectively collected progression rate. Different survival analysis methods were used to examine associations between blood parameters and survival. Results We found higher CK ( p -value 0.001), ALB ( p -value &lt;0.001), CREA ( p -value &lt;0.001), and HDL levels ( p -value 0.044) at time of diagnosis being associated with better functional status according to ALSFRS-R scores at study entry. Additionally, higher CREA levels were associated with lower risk of death ( p -value 0.003). Conclusions Our results indicate potential of CK, ALB, CREA, and HDL as disease severity or progression markers, and may also provide clues to ALS pathogenesis. However, these values are highly dependent on other variables, and further careful, longitudinal analyses will be necessary to prove the relevance of our findings." @default.
• W4288068583 created "2022-07-28" @default.
• W4288068583 creator A5005633849 @default.
• W4288068583 creator A5008634352 @default.
• W4288068583 creator A5014492344 @default.
• W4288068583 creator A5015908173 @default.
• W4288068583 creator A5018173987 @default.
• W4288068583 creator A5040831166 @default.
• W4288068583 creator A5053279441 @default.
• W4288068583 creator A5077614404 @default.
• W4288068583 creator A5082795436 @default.
• W4288068583 date "2022-07-27" @default.
• W4288068583 modified "2023-10-09" @default.
• W4288068583 title "Analysis of routine blood parameters in patients with amyotrophic lateral sclerosis and evaluation of a possible correlation with disease progression—a multicenter study" @default.
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