Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288069287> ?p ?o ?g. }
- W4288069287 endingPage "4769" @default.
- W4288069287 startingPage "4769" @default.
- W4288069287 abstract "(1) Background: Preclinical studies report that the ethanolic fraction from Mangifera indica leaves is a potential anti-acne agent. Nevertheless, the biological activity of Mangifera indica leaves has scarcely been investigated, and additional data are needed, especially in a clinical setting, for establishing the actual effectiveness of Mangifera indica extract as an active component of anti-acne therapy. (2) Methods: The evaluation of the biological activity of Mangifera indica extract was carried out through different experimental phases, which comprised in silico, in vitro, ex vivo and clinical evaluations. (3) Results: In silico and in vitro studies allowed us to identify the phytomarkers carrying the activity of seboregulation and acne management. Results showed that Mangifera indica extract reduced lipid production by 40% in sebocytes, and an improvement of the sebum quality was reported after the treatment in analyses performed on sebaceous glands from skin explants. The evaluation of the sebum quantity and quality using triglyceride/free fatty acid analysis conducted on Caucasian volunteers evidenced a strong improvement and a reduction of porphyrins expression. The C. acnes lipase activity from a severe acne phylotype was evaluated in the presence of Mangifera indica, and a reduction by 29% was reported. In addition, the analysis of the skin microbiota documented that Mangifera indica protected the microbiota equilibrium while the placebo induced dysbiosis. (4) Conclusions: Our results showed that Mangifera indica is microbiota friendly and efficient against lipase activity of C. acnes and supports a role for Mangifera indica in the therapeutic strategy for prevention and treatment of acne." @default.
- W4288069287 created "2022-07-28" @default.
- W4288069287 creator A5004382699 @default.
- W4288069287 creator A5030657835 @default.
- W4288069287 creator A5031267538 @default.
- W4288069287 creator A5037152838 @default.
- W4288069287 creator A5051719313 @default.
- W4288069287 creator A5054130372 @default.
- W4288069287 creator A5056555606 @default.
- W4288069287 creator A5058916338 @default.
- W4288069287 creator A5062413068 @default.
- W4288069287 creator A5080209623 @default.
- W4288069287 creator A5083538035 @default.
- W4288069287 creator A5088028763 @default.
- W4288069287 creator A5088977011 @default.
- W4288069287 date "2022-07-26" @default.
- W4288069287 modified "2023-09-26" @default.
- W4288069287 title "Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes" @default.
- W4288069287 cites W1697238413 @default.
- W4288069287 cites W1983187303 @default.
- W4288069287 cites W1987689482 @default.
- W4288069287 cites W1987764203 @default.
- W4288069287 cites W1992082093 @default.
- W4288069287 cites W2020328194 @default.
- W4288069287 cites W2038811593 @default.
- W4288069287 cites W2042861376 @default.
- W4288069287 cites W2048580323 @default.
- W4288069287 cites W2058399743 @default.
- W4288069287 cites W2063571258 @default.
- W4288069287 cites W2067243972 @default.
- W4288069287 cites W2110065044 @default.
- W4288069287 cites W2152885278 @default.
- W4288069287 cites W2194764270 @default.
- W4288069287 cites W2308887718 @default.
- W4288069287 cites W2341687793 @default.
- W4288069287 cites W2414316868 @default.
- W4288069287 cites W2508306553 @default.
- W4288069287 cites W2513506562 @default.
- W4288069287 cites W2610502245 @default.
- W4288069287 cites W2618886012 @default.
- W4288069287 cites W2926652335 @default.
- W4288069287 cites W2980412969 @default.
- W4288069287 cites W2981331284 @default.
- W4288069287 cites W2998884977 @default.
- W4288069287 cites W3008404945 @default.
- W4288069287 cites W3011230572 @default.
- W4288069287 cites W3021386872 @default.
- W4288069287 cites W3025458720 @default.
- W4288069287 cites W3099415278 @default.
- W4288069287 cites W3132015236 @default.
- W4288069287 cites W3159293386 @default.
- W4288069287 cites W3167084473 @default.
- W4288069287 doi "https://doi.org/10.3390/molecules27154769" @default.
- W4288069287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35897945" @default.
- W4288069287 hasPublicationYear "2022" @default.
- W4288069287 type Work @default.
- W4288069287 citedByCount "2" @default.
- W4288069287 countsByYear W42880692872023 @default.
- W4288069287 crossrefType "journal-article" @default.
- W4288069287 hasAuthorship W4288069287A5004382699 @default.
- W4288069287 hasAuthorship W4288069287A5030657835 @default.
- W4288069287 hasAuthorship W4288069287A5031267538 @default.
- W4288069287 hasAuthorship W4288069287A5037152838 @default.
- W4288069287 hasAuthorship W4288069287A5051719313 @default.
- W4288069287 hasAuthorship W4288069287A5054130372 @default.
- W4288069287 hasAuthorship W4288069287A5056555606 @default.
- W4288069287 hasAuthorship W4288069287A5058916338 @default.
- W4288069287 hasAuthorship W4288069287A5062413068 @default.
- W4288069287 hasAuthorship W4288069287A5080209623 @default.
- W4288069287 hasAuthorship W4288069287A5083538035 @default.
- W4288069287 hasAuthorship W4288069287A5088028763 @default.
- W4288069287 hasAuthorship W4288069287A5088977011 @default.
- W4288069287 hasBestOaLocation W42880692871 @default.
- W4288069287 hasConcept C16005928 @default.
- W4288069287 hasConcept C181199279 @default.
- W4288069287 hasConcept C185592680 @default.
- W4288069287 hasConcept C2777673923 @default.
- W4288069287 hasConcept C2779697368 @default.
- W4288069287 hasConcept C2779900937 @default.
- W4288069287 hasConcept C2780139979 @default.
- W4288069287 hasConcept C2781429666 @default.
- W4288069287 hasConcept C55493867 @default.
- W4288069287 hasConcept C556039675 @default.
- W4288069287 hasConcept C59822182 @default.
- W4288069287 hasConcept C71924100 @default.
- W4288069287 hasConcept C86803240 @default.
- W4288069287 hasConcept C98274493 @default.
- W4288069287 hasConceptScore W4288069287C16005928 @default.
- W4288069287 hasConceptScore W4288069287C181199279 @default.
- W4288069287 hasConceptScore W4288069287C185592680 @default.
- W4288069287 hasConceptScore W4288069287C2777673923 @default.
- W4288069287 hasConceptScore W4288069287C2779697368 @default.
- W4288069287 hasConceptScore W4288069287C2779900937 @default.
- W4288069287 hasConceptScore W4288069287C2780139979 @default.
- W4288069287 hasConceptScore W4288069287C2781429666 @default.
- W4288069287 hasConceptScore W4288069287C55493867 @default.
- W4288069287 hasConceptScore W4288069287C556039675 @default.
- W4288069287 hasConceptScore W4288069287C59822182 @default.