Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288074281> ?p ?o ?g. }
- W4288074281 abstract "Circadian dysregulation associates with numerous diseases including metabolic dysfunction, sleep disorder, depression and aging. Given that declined circadian amplitude is a trait commonly found with compromised health, interventions that design in precluding circadian amplitude from dampening will aid to mitigate complex, circadian-related diseases. Here we identify a neurogenic small molecule ISX-9 that is able to support persistent and higher amplitude of circadian oscillations. ISX-9 improves diurnal metabolic rhythms in middle-aged mice. Moreover, the ISX-9-treated mice show better sleep homeostasis with increased delta power during the day time and higher locomotive activity in the dark period. ISX-9 augments CaMKIIδ expression and increases BMAL1 activity via eliciting CaMKIIδ-mediated phosphorylation on BMAL1 residues S513/S515/S516, accordingly composes a positive feedback effect on enhancing circadian amplitude. CaMKIIδ-targeting, and the use of ISX-9 may serve as decent choices for treating circadian-related disorders." @default.
- W4288074281 created "2022-07-28" @default.
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- W4288074281 date "2022-07-28" @default.
- W4288074281 modified "2023-10-13" @default.
- W4288074281 title "ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude" @default.
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- W4288074281 doi "https://doi.org/10.1038/s42003-022-03725-x" @default.
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