Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288074797> ?p ?o ?g. }
- W4288074797 endingPage "652" @default.
- W4288074797 startingPage "644" @default.
- W4288074797 abstract "Abstract C282Y homozygotes exposed to sustained elevated transferrin saturation (TS) may develop worsening clinical symptoms. This might be related to the appearance of non‐transferrin bound iron (NTBI) when TS≥50% and labile plasma iron (LPI) when TS levels reach 75–80%. In this study, NTBI levels were examined in 219 randomly selected untreated and treated C282Y homozygotes. Overall, 161 of 219 had TS ≥ 50%, 124 of whom had detectable NTBI (≥0.47 µM, 1.81 µM [0.92–2.46 µM]) with a median serum ferritin 320 µg/L (226–442 µg/L). Ninety of 219 homozygotes had TS ≥ 75%, and all had detectable NTBI (2.21 µM [1.53–2.59 µM] with a median ferritin 338 µg/L [230–447 µg/L]). Of 125 homozygotes who last had phlebotomy ≥12 months ago (42 months [25–74 months], 92 had TS levels ≥ 50%, and 70 of these had NTBI ≥ 0.47 µM (2.06 µM [1.23–2.61µM]). Twenty‐six of these 70 had a normal ferritin. Fifty‐five of 125 had TS ≥ 75%, and NTBI was detected in all of these (2.32 µM [1.57–2.77 µM]) with a median ferritin 344 µg/L (255–418 µg/L). Eighteen of these 55 had a normal ferritin. In summary, NTBI is frequently found in C282Y homozygotes with TS ≥ 50%. Furthermore, C282Y homozygotes in the maintenance phase often have TS ≥ 50% together with a normal ferritin. Therefore, monitoring the TS level during the maintenance phase is recommended as an accessible clinical marker of the presence of NTBI." @default.
- W4288074797 created "2022-07-28" @default.
- W4288074797 creator A5002957640 @default.
- W4288074797 creator A5016304357 @default.
- W4288074797 creator A5034208780 @default.
- W4288074797 creator A5036624272 @default.
- W4288074797 creator A5086860007 @default.
- W4288074797 creator A5087904377 @default.
- W4288074797 date "2022-07-27" @default.
- W4288074797 modified "2023-09-26" @default.
- W4288074797 title "NTBI levels in C282Y homozygotes after therapeutic phlebotomy" @default.
- W4288074797 cites W1851314291 @default.
- W4288074797 cites W1979923361 @default.
- W4288074797 cites W1980042430 @default.
- W4288074797 cites W1983523884 @default.
- W4288074797 cites W1984960613 @default.
- W4288074797 cites W1989331670 @default.
- W4288074797 cites W2002605005 @default.
- W4288074797 cites W2007440356 @default.
- W4288074797 cites W2011115926 @default.
- W4288074797 cites W2013071898 @default.
- W4288074797 cites W2013435298 @default.
- W4288074797 cites W2017613177 @default.
- W4288074797 cites W2034328820 @default.
- W4288074797 cites W2055398309 @default.
- W4288074797 cites W2057478197 @default.
- W4288074797 cites W2059778114 @default.
- W4288074797 cites W2074000647 @default.
- W4288074797 cites W2082390213 @default.
- W4288074797 cites W2094559035 @default.
- W4288074797 cites W2096728978 @default.
- W4288074797 cites W2137350251 @default.
- W4288074797 cites W2142792785 @default.
- W4288074797 cites W2148362837 @default.
- W4288074797 cites W2190900500 @default.
- W4288074797 cites W2365126164 @default.
- W4288074797 cites W2404659621 @default.
- W4288074797 cites W2427510662 @default.
- W4288074797 cites W2573625026 @default.
- W4288074797 cites W2594684833 @default.
- W4288074797 cites W2626456941 @default.
- W4288074797 cites W2793944650 @default.
- W4288074797 cites W2805108339 @default.
- W4288074797 cites W2902895788 @default.
- W4288074797 cites W2903733210 @default.
- W4288074797 cites W3045507705 @default.
- W4288074797 cites W3047310795 @default.
- W4288074797 cites W4232013301 @default.
- W4288074797 cites W4247688670 @default.
- W4288074797 cites W7882087 @default.
- W4288074797 doi "https://doi.org/10.1002/jha2.507" @default.
- W4288074797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36051052" @default.
- W4288074797 hasPublicationYear "2022" @default.
- W4288074797 type Work @default.
- W4288074797 citedByCount "2" @default.
- W4288074797 countsByYear W42880747972023 @default.
- W4288074797 crossrefType "journal-article" @default.
- W4288074797 hasAuthorship W4288074797A5002957640 @default.
- W4288074797 hasAuthorship W4288074797A5016304357 @default.
- W4288074797 hasAuthorship W4288074797A5034208780 @default.
- W4288074797 hasAuthorship W4288074797A5036624272 @default.
- W4288074797 hasAuthorship W4288074797A5086860007 @default.
- W4288074797 hasAuthorship W4288074797A5087904377 @default.
- W4288074797 hasBestOaLocation W42880747972 @default.
- W4288074797 hasConcept C126322002 @default.
- W4288074797 hasConcept C153852466 @default.
- W4288074797 hasConcept C203014093 @default.
- W4288074797 hasConcept C22814914 @default.
- W4288074797 hasConcept C2776590208 @default.
- W4288074797 hasConcept C2777357209 @default.
- W4288074797 hasConcept C2778319317 @default.
- W4288074797 hasConcept C3019184707 @default.
- W4288074797 hasConcept C71924100 @default.
- W4288074797 hasConcept C90924648 @default.
- W4288074797 hasConceptScore W4288074797C126322002 @default.
- W4288074797 hasConceptScore W4288074797C153852466 @default.
- W4288074797 hasConceptScore W4288074797C203014093 @default.
- W4288074797 hasConceptScore W4288074797C22814914 @default.
- W4288074797 hasConceptScore W4288074797C2776590208 @default.
- W4288074797 hasConceptScore W4288074797C2777357209 @default.
- W4288074797 hasConceptScore W4288074797C2778319317 @default.
- W4288074797 hasConceptScore W4288074797C3019184707 @default.
- W4288074797 hasConceptScore W4288074797C71924100 @default.
- W4288074797 hasConceptScore W4288074797C90924648 @default.
- W4288074797 hasIssue "3" @default.
- W4288074797 hasLocation W42880747971 @default.
- W4288074797 hasLocation W42880747972 @default.
- W4288074797 hasLocation W42880747973 @default.
- W4288074797 hasLocation W42880747974 @default.
- W4288074797 hasOpenAccess W4288074797 @default.
- W4288074797 hasPrimaryLocation W42880747971 @default.
- W4288074797 hasRelatedWork W122250695 @default.
- W4288074797 hasRelatedWork W1987255124 @default.
- W4288074797 hasRelatedWork W1990954452 @default.
- W4288074797 hasRelatedWork W2034587996 @default.
- W4288074797 hasRelatedWork W2041715899 @default.
- W4288074797 hasRelatedWork W2126442499 @default.
- W4288074797 hasRelatedWork W2312842572 @default.