Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288077897> ?p ?o ?g. }
- W4288077897 abstract "Abstract Serine hydrolases play important roles in signaling and human metabolism, yet little is known about the functions of these enzymes in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal Bacteroides thetaiotaomicron that are specific to the Bacteroidetes phylum. Two are predicted homologs of the human protease dipeptidyl peptidase 4 (hDPP4), a key enzyme that regulates insulin signaling. Functional studies reveal that BT4193 is a true homolog of hDPP4 while the other is misannotated and is a proline-specific triaminopeptidase. We demonstrate that BT4193 is important for envelope integrity and is inhibited by FDA-approved type 2 diabetes drugs that target hDPP4. Loss of BT4193 reduces B. thetaiotaomicron fitness during in vitro growth within a diverse community. Taken together, our findings suggest that serine hydrolases contribute to gut microbiota dynamics and may be off-targets for existing drugs that could cause unintended impact on the microbiota." @default.
- W4288077897 created "2022-07-28" @default.
- W4288077897 creator A5002256644 @default.
- W4288077897 creator A5005853846 @default.
- W4288077897 creator A5020878856 @default.
- W4288077897 creator A5024240150 @default.
- W4288077897 creator A5026261319 @default.
- W4288077897 creator A5032059321 @default.
- W4288077897 creator A5043331848 @default.
- W4288077897 creator A5046154621 @default.
- W4288077897 creator A5050919240 @default.
- W4288077897 creator A5051720035 @default.
- W4288077897 creator A5052019253 @default.
- W4288077897 creator A5068117227 @default.
- W4288077897 creator A5080667439 @default.
- W4288077897 creator A5084562926 @default.
- W4288077897 creator A5086956310 @default.
- W4288077897 date "2022-07-26" @default.
- W4288077897 modified "2023-09-30" @default.
- W4288077897 title "Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in <i>Bacteroides thetaiotaomicron</i> important for envelope integrity and fitness" @default.
- W4288077897 cites W1550669392 @default.
- W4288077897 cites W1788530582 @default.
- W4288077897 cites W1963890672 @default.
- W4288077897 cites W1965204107 @default.
- W4288077897 cites W1972907910 @default.
- W4288077897 cites W1983719960 @default.
- W4288077897 cites W1999227915 @default.
- W4288077897 cites W2003113488 @default.
- W4288077897 cites W2005008585 @default.
- W4288077897 cites W2010922747 @default.
- W4288077897 cites W2015925270 @default.
- W4288077897 cites W2017627887 @default.
- W4288077897 cites W2028185344 @default.
- W4288077897 cites W2036321220 @default.
- W4288077897 cites W2044977356 @default.
- W4288077897 cites W2047730645 @default.
- W4288077897 cites W2052023845 @default.
- W4288077897 cites W2053449992 @default.
- W4288077897 cites W2071877589 @default.
- W4288077897 cites W2081319101 @default.
- W4288077897 cites W2081739151 @default.
- W4288077897 cites W2100819581 @default.
- W4288077897 cites W2103700658 @default.
- W4288077897 cites W2105635512 @default.
- W4288077897 cites W2107247090 @default.
- W4288077897 cites W2108744024 @default.
- W4288077897 cites W2108871577 @default.
- W4288077897 cites W2108923073 @default.
- W4288077897 cites W2109688740 @default.
- W4288077897 cites W2126784560 @default.
- W4288077897 cites W2128769815 @default.
- W4288077897 cites W2132662146 @default.
- W4288077897 cites W2138045215 @default.
- W4288077897 cites W2140145798 @default.
- W4288077897 cites W2151127919 @default.
- W4288077897 cites W2165824222 @default.
- W4288077897 cites W2169009504 @default.
- W4288077897 cites W2281147173 @default.
- W4288077897 cites W2281893628 @default.
- W4288077897 cites W2410254756 @default.
- W4288077897 cites W2463195069 @default.
- W4288077897 cites W2519618698 @default.
- W4288077897 cites W2570173529 @default.
- W4288077897 cites W2612143541 @default.
- W4288077897 cites W2623393796 @default.
- W4288077897 cites W2743274558 @default.
- W4288077897 cites W2758838202 @default.
- W4288077897 cites W2766287636 @default.
- W4288077897 cites W2779770955 @default.
- W4288077897 cites W2792021903 @default.
- W4288077897 cites W2803685741 @default.
- W4288077897 cites W2804589304 @default.
- W4288077897 cites W2886469784 @default.
- W4288077897 cites W2888489814 @default.
- W4288077897 cites W2897925715 @default.
- W4288077897 cites W2903406988 @default.
- W4288077897 cites W2904274321 @default.
- W4288077897 cites W2912990441 @default.
- W4288077897 cites W2914024845 @default.
- W4288077897 cites W2937736654 @default.
- W4288077897 cites W2947189704 @default.
- W4288077897 cites W2948160364 @default.
- W4288077897 cites W2948523675 @default.
- W4288077897 cites W2951031877 @default.
- W4288077897 cites W2951517287 @default.
- W4288077897 cites W2961446056 @default.
- W4288077897 cites W2998420978 @default.
- W4288077897 cites W3008966602 @default.
- W4288077897 cites W3016421776 @default.
- W4288077897 cites W3082389140 @default.
- W4288077897 cites W3083241614 @default.
- W4288077897 cites W3085638057 @default.
- W4288077897 cites W3133800719 @default.
- W4288077897 cites W3166972534 @default.
- W4288077897 cites W3177828909 @default.
- W4288077897 cites W3197782746 @default.
- W4288077897 cites W3202861230 @default.
- W4288077897 cites W3203894869 @default.
- W4288077897 cites W4205952448 @default.
- W4288077897 cites W4206324071 @default.