Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288081009> ?p ?o ?g. }
- W4288081009 abstract "Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant μ-opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have been developed in this work, modelled on the known agonist fentanyl, with the aim of expanding the current toolbox of fentanyl photoswitchable ligands. In doing so, ligands have been developed that change geometry (isomerize) upon exposure to light, with varying photophysical and biochemical properties. This variation in properties could be valuable in further studying the functional significance of the μ-opioid receptor." @default.
- W4288081009 created "2022-07-28" @default.
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- W4288081009 date "2022-09-12" @default.
- W4288081009 modified "2023-09-26" @default.
- W4288081009 title "Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation" @default.
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- W4288081009 doi "https://doi.org/10.1002/chem.202201515" @default.
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