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- W4288085497 endingPage "1074" @default.
- W4288085497 startingPage "1059" @default.
- W4288085497 abstract "Radiation therapy is a primary treatment modality for a variety of presentations of lung cancer, but thoracic radiotherapy can be associated with significant morbidities. Due to its unique physical properties, proton therapy can allow for significant dosimetric advantage for patients with lung cancer, reducing unnecessary irradiation doses to critical thoracic structures such as the lungs, esophagus, and heart while optimizing dose to the intended tumor volume. Compared with traditional photon therapy, the dose reductions to normal tissues achievable with proton therapy in select patients can achieve significantly fewer high-grade toxicities, more safely deliver dose escalation, more adequately treat bulky tumors adjacent to critical structures, improve the therapeutic ratio of trimodality therapy, and offer a new chance of cure following locoregional recurrence after prior radiotherapy. Passively scattered and pencil beam scanning proton therapy are discussed, with pencil beam scanning affording greater dose conformality and potentially superior clinical outcomes. Proton therapy has an increasingly well-demonstrated role in the treatment of both early-stage and locally advanced non-small cell lung cancer that is detailed in this chapter. Proton therapy also has emerging roles for other thoracic malignancies, including small cell lung cancer, esophageal cancer, thymic tumors, malignant pleural mesothelioma, and cardiac malignancies. Prospective randomized evidence is emerging supporting its use as a standard treatment to optimize thoracic radiotherapy." @default.
- W4288085497 created "2022-07-28" @default.
- W4288085497 creator A5067536094 @default.
- W4288085497 date "2022-01-01" @default.
- W4288085497 modified "2023-09-25" @default.
- W4288085497 title "Heavy Particles in Non-small Cell Lung Cancer: Protons" @default.
- W4288085497 cites W1494104030 @default.
- W4288085497 cites W1587945793 @default.
- W4288085497 cites W1750853185 @default.
- W4288085497 cites W1821450973 @default.
- W4288085497 cites W1964207627 @default.
- W4288085497 cites W1966418691 @default.
- W4288085497 cites W1966749611 @default.
- W4288085497 cites W1968899146 @default.
- W4288085497 cites W1971360992 @default.
- W4288085497 cites W1973318362 @default.
- W4288085497 cites W1978156658 @default.
- W4288085497 cites W1980756937 @default.
- W4288085497 cites W1981905971 @default.
- W4288085497 cites W1984068275 @default.
- W4288085497 cites W1999247253 @default.
- W4288085497 cites W2002656831 @default.
- W4288085497 cites W2002953537 @default.
- W4288085497 cites W2005005453 @default.
- W4288085497 cites W2009367169 @default.
- W4288085497 cites W2023731297 @default.
- W4288085497 cites W2024836029 @default.
- W4288085497 cites W2025510921 @default.
- W4288085497 cites W2029728138 @default.
- W4288085497 cites W2045903651 @default.
- W4288085497 cites W2054729949 @default.
- W4288085497 cites W2055524435 @default.
- W4288085497 cites W2063753553 @default.
- W4288085497 cites W2066369833 @default.
- W4288085497 cites W2071364157 @default.
- W4288085497 cites W2073093286 @default.
- W4288085497 cites W2080126859 @default.
- W4288085497 cites W2081901297 @default.
- W4288085497 cites W2095148496 @default.
- W4288085497 cites W2098354451 @default.
- W4288085497 cites W2104701073 @default.
- W4288085497 cites W2110876229 @default.
- W4288085497 cites W2110996227 @default.
- W4288085497 cites W2112455219 @default.
- W4288085497 cites W2122888341 @default.
- W4288085497 cites W2141498930 @default.
- W4288085497 cites W2150526590 @default.
- W4288085497 cites W2152137128 @default.
- W4288085497 cites W2152939220 @default.
- W4288085497 cites W2158499570 @default.
- W4288085497 cites W2159746573 @default.
- W4288085497 cites W2159751658 @default.
- W4288085497 cites W2168579915 @default.
- W4288085497 cites W2179171978 @default.
- W4288085497 cites W2250725820 @default.
- W4288085497 cites W2261340646 @default.
- W4288085497 cites W2263844620 @default.
- W4288085497 cites W2323020638 @default.
- W4288085497 cites W2340676938 @default.
- W4288085497 cites W2345933175 @default.
- W4288085497 cites W2415253133 @default.
- W4288085497 cites W2531388082 @default.
- W4288085497 cites W2531483814 @default.
- W4288085497 cites W2537137666 @default.
- W4288085497 cites W2549005298 @default.
- W4288085497 cites W2559816654 @default.
- W4288085497 cites W2568843865 @default.
- W4288085497 cites W2582044645 @default.
- W4288085497 cites W2591160334 @default.
- W4288085497 cites W2595526561 @default.
- W4288085497 cites W2596281330 @default.
- W4288085497 cites W2606204753 @default.
- W4288085497 cites W2609606527 @default.
- W4288085497 cites W2609968117 @default.
- W4288085497 cites W2616226761 @default.
- W4288085497 cites W2620549955 @default.
- W4288085497 cites W2621684067 @default.
- W4288085497 cites W2624942935 @default.
- W4288085497 cites W2699278758 @default.
- W4288085497 cites W2733328118 @default.
- W4288085497 cites W2737087640 @default.
- W4288085497 cites W2751756130 @default.
- W4288085497 cites W2751913107 @default.
- W4288085497 cites W2756886674 @default.
- W4288085497 cites W2761530580 @default.
- W4288085497 cites W2781965877 @default.
- W4288085497 cites W2792307000 @default.
- W4288085497 cites W2792973120 @default.
- W4288085497 cites W2795642783 @default.
- W4288085497 cites W2798984677 @default.
- W4288085497 cites W2802398047 @default.
- W4288085497 cites W2805193389 @default.
- W4288085497 cites W2896017731 @default.
- W4288085497 cites W2911260009 @default.
- W4288085497 cites W2913391388 @default.
- W4288085497 cites W2916830536 @default.
- W4288085497 cites W2944301866 @default.
- W4288085497 cites W2945602838 @default.