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- W4288085613 abstract "The aim of this study was to evaluate the genetic activity of a number of medicinal drugs on a model of mice peripheral blood erythrocytes. In our work, we studied the ability of adrenergic agonists and adrenergic blockers – lipid metabolism modulators – to induce two opposite effects in the cell: mutagenesis and antimutagenesis. The method, we used for the analysis of chromosomal mutations after the administration of the analyzed drugs in the mice peripheral blood erythrocytes made it possible to obtain a visual and detailed idea of the genetic effects of ligands involved in lipid metabolism. It is shown that genome instability, expressed in the formation of micronuclei in the mice peripheral blood erythrocytes as a result of a single action of the cyclophosphamide mutagen (at a dose of 30 mg/kg) is significantly reduced by lipid metabolism modulators (both stimulants and blockers of α- and β-adrenergic receptors). The α-adrenergic receptor ligands – phenylephrine (stimulant) and proroxan (blocker), as well as the β-adrenergic receptor ligands – orciprenaline (stimulant) and propranolol (blocker) – have an antimutagenic effect. The maximum antimutagenic effect of phenylephrine is at doses of 1 and 10 mg/ kg, of proroxan – 1 mg/kg, orciprenaline – at a dose of 0,5 mg/kg, propranolol – 1×10–3 and 1 mg/kg." @default.
- W4288085613 created "2022-07-28" @default.
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- W4288085613 date "2022-01-01" @default.
- W4288085613 modified "2023-09-25" @default.
- W4288085613 title "Assessment of the protective activity of a number of medicinal drugs on the model of mice erythrocytes" @default.
- W4288085613 doi "https://doi.org/10.36871/vet.zoo.bio.202205005" @default.
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