FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288096020> ?p ?o ?g. }

• W4288096020 abstract "NKG2D ligands play a relevant role in Natural Killer (NK) cell -mediated immune surveillance of multiple myeloma (MM). Different levels of regulation control the expression of these molecules at cell surface. A number of oncogenic proteins and miRNAs act as negative regulators of NKG2D ligand transcription and translation, but the molecular mechanisms sustaining their basal expression in MM cells remain poorly understood. Here, we evaluated the role of the growth arrest specific 6 (GAS6)/TAM signaling pathway in the regulation of NKG2D ligand expression and MM recognition by NK cells. Our data showed that GAS6 as well as MERTK and AXL depletion in MM cells results in MICA downregulation and inhibition of NKG2D-mediated NK cell degranulation. Noteworthy, GAS6 derived from bone marrow stromal cells (BMSCs) also increases MICA expression at both protein and mRNA level in human MM cell lines and in primary malignant plasma cells. NF-kB activation is required for these regulatory mechanisms since deletion of a site responsive for this transcription factor compromises the induction of mica promoter by BMSCs. Accordingly, knockdown of GAS6 reduces the capability of BMSCs to activate NF-kB pathway as well as to enhance MICA expression in MM cells. Taken together, these results shed light on molecular mechanism underlying NKG2D ligand regulation and identify GAS6 protein as a novel autocrine and paracrine regulator of basal expression of MICA in human MM cells." @default.
• W4288096020 created "2022-07-28" @default.
• W4288096020 creator A5013314995 @default.
• W4288096020 creator A5017694699 @default.
• W4288096020 creator A5024871281 @default.
• W4288096020 creator A5037925152 @default.
• W4288096020 creator A5040070739 @default.
• W4288096020 creator A5045814742 @default.
• W4288096020 creator A5058127027 @default.
• W4288096020 creator A5062614877 @default.
• W4288096020 creator A5063846820 @default.
• W4288096020 creator A5069805862 @default.
• W4288096020 creator A5071777583 @default.
• W4288096020 creator A5074159017 @default.
• W4288096020 date "2022-07-28" @default.
• W4288096020 modified "2023-10-14" @default.
• W4288096020 title "GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells" @default.
• W4288096020 cites W1481809543 @default.
• W4288096020 cites W1555729280 @default.
• W4288096020 cites W1977385137 @default.
• W4288096020 cites W1978921205 @default.
• W4288096020 cites W1984437179 @default.
• W4288096020 cites W1995477446 @default.
• W4288096020 cites W2002768361 @default.
• W4288096020 cites W2023283620 @default.
• W4288096020 cites W2053546689 @default.
• W4288096020 cites W2056010443 @default.
• W4288096020 cites W2081484203 @default.
• W4288096020 cites W2088565779 @default.
• W4288096020 cites W2099126386 @default.
• W4288096020 cites W2113558629 @default.
• W4288096020 cites W2132557616 @default.
• W4288096020 cites W2139380919 @default.
• W4288096020 cites W2141753187 @default.
• W4288096020 cites W2144201925 @default.
• W4288096020 cites W2150903105 @default.
• W4288096020 cites W2159771756 @default.
• W4288096020 cites W2221432805 @default.
• W4288096020 cites W2329072188 @default.
• W4288096020 cites W2538488403 @default.
• W4288096020 cites W2557965424 @default.
• W4288096020 cites W2559419629 @default.
• W4288096020 cites W2585858009 @default.
• W4288096020 cites W2609769996 @default.
• W4288096020 cites W2610858500 @default.
• W4288096020 cites W2742185070 @default.
• W4288096020 cites W2753162131 @default.
• W4288096020 cites W2758278214 @default.
• W4288096020 cites W2793215815 @default.
• W4288096020 cites W2802986564 @default.
• W4288096020 cites W2809444806 @default.
• W4288096020 cites W2886319510 @default.
• W4288096020 cites W2897079850 @default.
• W4288096020 cites W2902890722 @default.
• W4288096020 cites W2911130828 @default.
• W4288096020 cites W2919360421 @default.
• W4288096020 cites W2940720641 @default.
• W4288096020 cites W2955871897 @default.
• W4288096020 cites W2971991240 @default.
• W4288096020 cites W2973731413 @default.
• W4288096020 cites W2982911882 @default.
• W4288096020 cites W2989373316 @default.
• W4288096020 cites W3005827420 @default.
• W4288096020 cites W3011326164 @default.
• W4288096020 cites W3104378038 @default.
• W4288096020 cites W3120276288 @default.
• W4288096020 cites W3120414804 @default.
• W4288096020 cites W3135705050 @default.
• W4288096020 cites W3158935025 @default.
• W4288096020 cites W3162134861 @default.
• W4288096020 cites W3164965424 @default.
• W4288096020 cites W3183440914 @default.
• W4288096020 cites W3195696799 @default.
• W4288096020 cites W4205280780 @default.
• W4288096020 doi "https://doi.org/10.3389/fimmu.2022.942640" @default.
• W4288096020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35967396" @default.
• W4288096020 hasPublicationYear "2022" @default.
• W4288096020 type Work @default.
• W4288096020 citedByCount "1" @default.
• W4288096020 countsByYear W42880960202023 @default.
• W4288096020 crossrefType "journal-article" @default.
• W4288096020 hasAuthorship W4288096020A5013314995 @default.
• W4288096020 hasAuthorship W4288096020A5017694699 @default.
• W4288096020 hasAuthorship W4288096020A5024871281 @default.
• W4288096020 hasAuthorship W4288096020A5037925152 @default.
• W4288096020 hasAuthorship W4288096020A5040070739 @default.
• W4288096020 hasAuthorship W4288096020A5045814742 @default.
• W4288096020 hasAuthorship W4288096020A5058127027 @default.
• W4288096020 hasAuthorship W4288096020A5062614877 @default.
• W4288096020 hasAuthorship W4288096020A5063846820 @default.
• W4288096020 hasAuthorship W4288096020A5069805862 @default.
• W4288096020 hasAuthorship W4288096020A5071777583 @default.
• W4288096020 hasAuthorship W4288096020A5074159017 @default.
• W4288096020 hasBestOaLocation W42880960201 @default.
• W4288096020 hasConcept C101544691 @default.
• W4288096020 hasConcept C109316439 @default.
• W4288096020 hasConcept C128240485 @default.
• W4288096020 hasConcept C170493617 @default.
• W4288096020 hasConcept C172811965 @default.
• W4288096020 hasConcept C185592680 @default.

• next