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- W4288096981 abstract "In addition to neuroprotective strategies, neuroregenerative processes could provide targets for stroke recovery. However, the upregulation of inhibitory chondroitin sulfate proteoglycans (CSPGs) impedes innate regenerative efforts. Here, we examine the regulatory role of PTPσ (a major proteoglycan receptor) in dampening post-stroke recovery. Use of a receptor modulatory peptide (ISP) or Ptprs gene deletion leads to increased neurite outgrowth and enhanced NSCs migration upon inhibitory CSPG substrates. Post-stroke ISP treatment results in increased axonal sprouting as well as neuroblast migration deeply into the lesion scar with a transcriptional signature reflective of repair. Lastly, peptide treatment post-stroke (initiated acutely or more chronically at 7 days) results in improved behavioral recovery in both motor and cognitive functions. Therefore, we propose that CSPGs induced by stroke play a predominant role in the regulation of neural repair and that blocking CSPG signaling pathways will lead to enhanced neurorepair and functional recovery in stroke." @default.
- W4288096981 created "2022-07-28" @default.
- W4288096981 creator A5001997941 @default.
- W4288096981 creator A5005142784 @default.
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- W4288096981 creator A5089978635 @default.
- W4288096981 date "2022-07-01" @default.
- W4288096981 modified "2023-09-30" @default.
- W4288096981 title "Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke" @default.
- W4288096981 cites W1483922385 @default.
- W4288096981 cites W1501014477 @default.
- W4288096981 cites W1555455083 @default.
- W4288096981 cites W1616800086 @default.
- W4288096981 cites W1929544011 @default.
- W4288096981 cites W1963765937 @default.
- W4288096981 cites W1963966302 @default.
- W4288096981 cites W1967109943 @default.
- W4288096981 cites W1982439010 @default.
- W4288096981 cites W1982539946 @default.
- W4288096981 cites W1985297297 @default.
- W4288096981 cites W1995654132 @default.
- W4288096981 cites W1995792973 @default.
- W4288096981 cites W1997134216 @default.
- W4288096981 cites W2000317431 @default.
- W4288096981 cites W2001915682 @default.
- W4288096981 cites W2003133530 @default.
- W4288096981 cites W2003982930 @default.
- W4288096981 cites W2006686107 @default.
- W4288096981 cites W2013997823 @default.
- W4288096981 cites W2014386715 @default.
- W4288096981 cites W2017741174 @default.
- W4288096981 cites W2031942587 @default.
- W4288096981 cites W2037220592 @default.
- W4288096981 cites W2043930451 @default.
- W4288096981 cites W2044343841 @default.
- W4288096981 cites W2050689607 @default.
- W4288096981 cites W2064212861 @default.
- W4288096981 cites W2067000225 @default.
- W4288096981 cites W2070967771 @default.
- W4288096981 cites W2075317738 @default.
- W4288096981 cites W2079356804 @default.
- W4288096981 cites W2084995170 @default.
- W4288096981 cites W2085444662 @default.
- W4288096981 cites W2086085796 @default.
- W4288096981 cites W2095263564 @default.
- W4288096981 cites W2096796354 @default.
- W4288096981 cites W2097530133 @default.
- W4288096981 cites W2104135721 @default.
- W4288096981 cites W2104968232 @default.
- W4288096981 cites W2108257172 @default.
- W4288096981 cites W2108438047 @default.
- W4288096981 cites W2109503237 @default.
- W4288096981 cites W2112505121 @default.
- W4288096981 cites W2114170875 @default.
- W4288096981 cites W2116378996 @default.
- W4288096981 cites W2121118396 @default.
- W4288096981 cites W2122230709 @default.
- W4288096981 cites W2126182481 @default.
- W4288096981 cites W2126328573 @default.
- W4288096981 cites W2128375499 @default.
- W4288096981 cites W2129497750 @default.
- W4288096981 cites W2134526812 @default.
- W4288096981 cites W2144994572 @default.
- W4288096981 cites W2157650341 @default.
- W4288096981 cites W2159416558 @default.
- W4288096981 cites W2166615294 @default.
- W4288096981 cites W2168272960 @default.
- W4288096981 cites W2168438949 @default.
- W4288096981 cites W2171229946 @default.
- W4288096981 cites W2179438025 @default.
- W4288096981 cites W2304707465 @default.
- W4288096981 cites W2550642044 @default.
- W4288096981 cites W2554967734 @default.
- W4288096981 cites W2580792129 @default.
- W4288096981 cites W2611742179 @default.
- W4288096981 cites W2612781716 @default.
- W4288096981 cites W2761230667 @default.
- W4288096981 cites W2765871207 @default.
- W4288096981 cites W2768378152 @default.
- W4288096981 cites W2794351872 @default.
- W4288096981 cites W2803963145 @default.
- W4288096981 cites W2804151471 @default.
- W4288096981 cites W2807094631 @default.
- W4288096981 cites W2884540135 @default.
- W4288096981 cites W2887620797 @default.
- W4288096981 cites W2888107430 @default.
- W4288096981 cites W2891534727 @default.
- W4288096981 cites W2894739441 @default.
- W4288096981 cites W2900187488 @default.
- W4288096981 cites W2913211528 @default.
- W4288096981 cites W2943784805 @default.
- W4288096981 cites W2944545583 @default.
- W4288096981 cites W2964849163 @default.