Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288096985> ?p ?o ?g. }
- W4288096985 endingPage "111133" @default.
- W4288096985 startingPage "111133" @default.
- W4288096985 abstract "Many viruses encode RNA-modifying enzymes to edit the 5′ end of viral RNA to mimic the cellular mRNA for effective protein translation, genome replication, and evasion of the host defense mechanisms. Alphavirus nsP1 synthesizes the 5′ end Cap-0 structure of viral RNAs. However, the molecular basis of the capping process remains unclear. We determine high-resolution cryoelectron microscopy (cryo-EM) structures of Chikungunya virus nsP1 in complex with m7GTP/SAH, covalently attached m7GMP, and Cap-0 viral RNA. These structures reveal details of viral-RNA-capping reactions and uncover a sequence-specific virus RNA-recognition pattern that, in turn, regulates viral-RNA-capping efficiency to ensure optimal genome replication and subgenomic RNA transcription. This sequence-specific enzyme-RNA pairing is conserved across all alphaviruses." @default.
- W4288096985 created "2022-07-28" @default.
- W4288096985 creator A5010169482 @default.
- W4288096985 creator A5030022994 @default.
- W4288096985 creator A5031992694 @default.
- W4288096985 creator A5039708869 @default.
- W4288096985 creator A5042031508 @default.
- W4288096985 creator A5065520731 @default.
- W4288096985 creator A5076403164 @default.
- W4288096985 creator A5086229138 @default.
- W4288096985 date "2022-07-01" @default.
- W4288096985 modified "2023-09-27" @default.
- W4288096985 title "Molecular basis of specific viral RNA recognition and 5′-end capping by the Chikungunya virus nsP1" @default.
- W4288096985 cites W1605480781 @default.
- W4288096985 cites W1855484651 @default.
- W4288096985 cites W1863063757 @default.
- W4288096985 cites W1931480957 @default.
- W4288096985 cites W1968072008 @default.
- W4288096985 cites W1969955120 @default.
- W4288096985 cites W1971655290 @default.
- W4288096985 cites W1980892321 @default.
- W4288096985 cites W2022342738 @default.
- W4288096985 cites W2026949398 @default.
- W4288096985 cites W2037243997 @default.
- W4288096985 cites W2046828533 @default.
- W4288096985 cites W2081423576 @default.
- W4288096985 cites W2105529329 @default.
- W4288096985 cites W2106478835 @default.
- W4288096985 cites W2124026197 @default.
- W4288096985 cites W2132629607 @default.
- W4288096985 cites W2132732723 @default.
- W4288096985 cites W2144081223 @default.
- W4288096985 cites W2151882149 @default.
- W4288096985 cites W2154480405 @default.
- W4288096985 cites W2172429771 @default.
- W4288096985 cites W2180229411 @default.
- W4288096985 cites W2294414054 @default.
- W4288096985 cites W2442161751 @default.
- W4288096985 cites W2514160356 @default.
- W4288096985 cites W2577558456 @default.
- W4288096985 cites W2587625522 @default.
- W4288096985 cites W2593511418 @default.
- W4288096985 cites W2768886517 @default.
- W4288096985 cites W2790311195 @default.
- W4288096985 cites W2800493285 @default.
- W4288096985 cites W2801933364 @default.
- W4288096985 cites W2939105285 @default.
- W4288096985 cites W2945827648 @default.
- W4288096985 cites W3001098727 @default.
- W4288096985 cites W3104955345 @default.
- W4288096985 cites W3111328403 @default.
- W4288096985 cites W3136024933 @default.
- W4288096985 cites W3154459164 @default.
- W4288096985 cites W3162745468 @default.
- W4288096985 cites W3183891994 @default.
- W4288096985 doi "https://doi.org/10.1016/j.celrep.2022.111133" @default.
- W4288096985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35905713" @default.
- W4288096985 hasPublicationYear "2022" @default.
- W4288096985 type Work @default.
- W4288096985 citedByCount "9" @default.
- W4288096985 countsByYear W42880969852022 @default.
- W4288096985 countsByYear W42880969852023 @default.
- W4288096985 crossrefType "journal-article" @default.
- W4288096985 hasAuthorship W4288096985A5010169482 @default.
- W4288096985 hasAuthorship W4288096985A5030022994 @default.
- W4288096985 hasAuthorship W4288096985A5031992694 @default.
- W4288096985 hasAuthorship W4288096985A5039708869 @default.
- W4288096985 hasAuthorship W4288096985A5042031508 @default.
- W4288096985 hasAuthorship W4288096985A5065520731 @default.
- W4288096985 hasAuthorship W4288096985A5076403164 @default.
- W4288096985 hasAuthorship W4288096985A5086229138 @default.
- W4288096985 hasBestOaLocation W42880969851 @default.
- W4288096985 hasConcept C104317684 @default.
- W4288096985 hasConcept C138885662 @default.
- W4288096985 hasConcept C140704245 @default.
- W4288096985 hasConcept C159047783 @default.
- W4288096985 hasConcept C179926584 @default.
- W4288096985 hasConcept C189819185 @default.
- W4288096985 hasConcept C194993378 @default.
- W4288096985 hasConcept C21786251 @default.
- W4288096985 hasConcept C2522874641 @default.
- W4288096985 hasConcept C2777474056 @default.
- W4288096985 hasConcept C2779174946 @default.
- W4288096985 hasConcept C2779755945 @default.
- W4288096985 hasConcept C41258723 @default.
- W4288096985 hasConcept C41895202 @default.
- W4288096985 hasConcept C54355233 @default.
- W4288096985 hasConcept C67705224 @default.
- W4288096985 hasConcept C86803240 @default.
- W4288096985 hasConcept C95444343 @default.
- W4288096985 hasConceptScore W4288096985C104317684 @default.
- W4288096985 hasConceptScore W4288096985C138885662 @default.
- W4288096985 hasConceptScore W4288096985C140704245 @default.
- W4288096985 hasConceptScore W4288096985C159047783 @default.
- W4288096985 hasConceptScore W4288096985C179926584 @default.
- W4288096985 hasConceptScore W4288096985C189819185 @default.
- W4288096985 hasConceptScore W4288096985C194993378 @default.
- W4288096985 hasConceptScore W4288096985C21786251 @default.