Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288096989> ?p ?o ?g. }
- W4288096989 endingPage "111136" @default.
- W4288096989 startingPage "111136" @default.
- W4288096989 abstract "Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyte development. We find that HOTAIR interacts with polycomb repressive complex 2 (PRC2) and we identify core HOTAIR-PRC2 target genes involved in adipocyte lineage determination. Repression of target genes coincides with PRC2 promoter occupancy and H3K27 trimethylation. HOTAIR is also involved in modifying the gluteal adipocyte transcriptome through alternative splicing. Gluteal-specific expression of HOTAIR is maintained by defined regions of open chromatin across the HOTAIR promoter. HOTAIR expression levels can be modified by hormonal (estrogen, glucocorticoids) and genetic variation (rs1443512 is a HOTAIR eQTL associated with reduced gynoid fat mass). These data identify HOTAIR as a dynamic regulator of the gluteal adipocyte transcriptome and epigenome with functional importance for human regional AT development." @default.
- W4288096989 created "2022-07-28" @default.
- W4288096989 creator A5000717053 @default.
- W4288096989 creator A5005477451 @default.
- W4288096989 creator A5012812099 @default.
- W4288096989 creator A5015433047 @default.
- W4288096989 creator A5031530399 @default.
- W4288096989 creator A5034258878 @default.
- W4288096989 creator A5034518803 @default.
- W4288096989 creator A5036922805 @default.
- W4288096989 creator A5047242210 @default.
- W4288096989 creator A5051598717 @default.
- W4288096989 creator A5055584673 @default.
- W4288096989 creator A5064946935 @default.
- W4288096989 creator A5068280372 @default.
- W4288096989 creator A5072506531 @default.
- W4288096989 creator A5075801926 @default.
- W4288096989 creator A5077859263 @default.
- W4288096989 creator A5081106889 @default.
- W4288096989 date "2022-07-01" @default.
- W4288096989 modified "2023-10-14" @default.
- W4288096989 title "HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution" @default.
- W4288096989 cites W1946661286 @default.
- W4288096989 cites W1947421479 @default.
- W4288096989 cites W1962960380 @default.
- W4288096989 cites W1965838838 @default.
- W4288096989 cites W1966327575 @default.
- W4288096989 cites W1966775465 @default.
- W4288096989 cites W1969609924 @default.
- W4288096989 cites W1974223972 @default.
- W4288096989 cites W1977093862 @default.
- W4288096989 cites W1979768717 @default.
- W4288096989 cites W1980719167 @default.
- W4288096989 cites W1986054293 @default.
- W4288096989 cites W1989505891 @default.
- W4288096989 cites W1991321219 @default.
- W4288096989 cites W2011879414 @default.
- W4288096989 cites W2012206989 @default.
- W4288096989 cites W2016015848 @default.
- W4288096989 cites W2020331673 @default.
- W4288096989 cites W2024148591 @default.
- W4288096989 cites W2045852033 @default.
- W4288096989 cites W2045913350 @default.
- W4288096989 cites W2047783882 @default.
- W4288096989 cites W2050767863 @default.
- W4288096989 cites W2059148293 @default.
- W4288096989 cites W2062502437 @default.
- W4288096989 cites W2064879520 @default.
- W4288096989 cites W2069264443 @default.
- W4288096989 cites W2071271349 @default.
- W4288096989 cites W2072087746 @default.
- W4288096989 cites W2073759231 @default.
- W4288096989 cites W2080080140 @default.
- W4288096989 cites W2082624580 @default.
- W4288096989 cites W2084990854 @default.
- W4288096989 cites W2095739285 @default.
- W4288096989 cites W2098023402 @default.
- W4288096989 cites W2098373558 @default.
- W4288096989 cites W2110330424 @default.
- W4288096989 cites W2114377124 @default.
- W4288096989 cites W2116236561 @default.
- W4288096989 cites W2118689874 @default.
- W4288096989 cites W2123882343 @default.
- W4288096989 cites W2126504590 @default.
- W4288096989 cites W2136417592 @default.
- W4288096989 cites W2138207763 @default.
- W4288096989 cites W2140247198 @default.
- W4288096989 cites W2140727482 @default.
- W4288096989 cites W2141624808 @default.
- W4288096989 cites W2146512944 @default.
- W4288096989 cites W2147449548 @default.
- W4288096989 cites W2148245224 @default.
- W4288096989 cites W2149791927 @default.
- W4288096989 cites W2153424791 @default.
- W4288096989 cites W2156880688 @default.
- W4288096989 cites W2160333540 @default.
- W4288096989 cites W2160565685 @default.
- W4288096989 cites W2161224111 @default.
- W4288096989 cites W2161245845 @default.
- W4288096989 cites W2169456326 @default.
- W4288096989 cites W2179438025 @default.
- W4288096989 cites W2197124664 @default.
- W4288096989 cites W2268624619 @default.
- W4288096989 cites W2466943387 @default.
- W4288096989 cites W2519616827 @default.
- W4288096989 cites W2522628945 @default.
- W4288096989 cites W2551499720 @default.
- W4288096989 cites W2559236589 @default.
- W4288096989 cites W2567812202 @default.
- W4288096989 cites W2586972673 @default.
- W4288096989 cites W2591570422 @default.
- W4288096989 cites W2592811885 @default.
- W4288096989 cites W2620406790 @default.
- W4288096989 cites W2740481656 @default.
- W4288096989 cites W2770092353 @default.
- W4288096989 cites W2770178180 @default.
- W4288096989 cites W2774307122 @default.
- W4288096989 cites W2780604249 @default.