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- W4288102410 abstract "The cell cortex, a thin film of active material assembled below the cell membrane, plays a key role in cellular symmetry breaking processes such as cell polarity establishment and cell division. Here, we present a minimal model of the self-organization of the cell cortex that is based on a hydrodynamic theory of curved active surfaces. Active stresses on this surface are regulated by a diffusing molecular species. We show that coupling of the active surface to a passive bulk fluid enables spontaneous polarization and the formation of a contractile ring on the surface via mechano-chemical instabilities. We discuss the role of external fields in guiding such pattern formation. Our work reveals that key features of cellular symmetry breaking and cell division can emerge in a minimal model via general dynamic instabilities." @default.
- W4288102410 created "2022-07-28" @default.
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- W4288102410 date "2019-09-26" @default.
- W4288102410 modified "2023-10-14" @default.
- W4288102410 title "Minimal model of cellular symmetry breaking" @default.
- W4288102410 doi "https://doi.org/10.48550/arxiv.1909.12804" @default.
- W4288102410 hasPublicationYear "2019" @default.
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