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- W4288287083 abstract "Cellular functions are established through biological evolution, but are constrained by the laws of physics. For instance, the physics of protein folding limits the lengths of cellular polypeptide chains. Consequently, many cellular functions are carried out not by long, isolated proteins, but rather by multi-protein complexes. Protein complexes themselves do not escape physical constraints, one of the most important being the difficulty to assemble reliably in the presence of cellular noise. In order to lay the foundation for a theory of reliable protein complex assembly, we study here an equilibrium thermodynamic model of self-assembly that exhibits four distinct assembly behaviors: diluted protein solution, liquid mixture, chimeric assembly and multifarious assembly. In the latter regime, different protein complexes can coexist without forming erroneous chimeric structures. We show that two conditions have to be fulfilled to attain this regime: (i) the composition of the complexes needs to be sufficiently heterogeneous, and (ii) the use of the set of components by the complexes has to be sparse. Our analysis of publicly available databases of protein complexes indicates that cellular protein systems might have indeed evolved so to satisfy both of these conditions." @default.
- W4288287083 created "2022-07-28" @default.
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- W4288287083 date "2019-07-05" @default.
- W4288287083 modified "2023-09-26" @default.
- W4288287083 title "Towards a theory of assembly of protein complexes: lessons from equilibrium statistical physics" @default.
- W4288287083 doi "https://doi.org/10.48550/arxiv.1907.02992" @default.
- W4288287083 hasPublicationYear "2019" @default.
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