FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288366249> ?p ?o ?g. }

• W4288366249 abstract "Identifying which taxa in our microbiota are associated with traits of interest is important for advancing science and health. However, the identification is challenging because the measured vector of taxa counts (by amplicon sequencing) is compositional, so a change in the abundance of one taxon in the microbiota induces a change in the number of sequenced counts across all taxa. The data is typically sparse, with zero counts present either due to biological variance or limited sequencing depth (technical zeros). For low abundance taxa, the chance for technical zeros is non-negligible. We show that existing methods designed to identify differential abundance for compositional data may have an inflated number of false positives due to improper handling of the zero counts. We introduce a novel non-parametric approach which provides valid inference even when the fraction of zero counts is substantial. Our approach uses a set of reference taxa that are non-differentially abundant, which can be estimated from the data or from outside information. We show the usefulness of our approach via simulations, as well as on three different data sets: a Crohn's disease study, the Human Microbiome Project, and an experiment with 'spiked-in' bacteria." @default.
• W4288366249 created "2022-07-29" @default.
• W4288366249 creator A5050320409 @default.
• W4288366249 creator A5070733780 @default.
• W4288366249 creator A5089088705 @default.
• W4288366249 date "2019-04-18" @default.
• W4288366249 modified "2023-10-18" @default.
• W4288366249 title "Testing for differential abundance in compositional counts data, with application to microbiome studies" @default.
• W4288366249 cites W1986195823 @default.
• W4288366249 cites W1986908904 @default.
• W4288366249 cites W1988925586 @default.
• W4288366249 cites W1991669423 @default.
• W4288366249 cites W1993436046 @default.
• W4288366249 cites W2004014148 @default.
• W4288366249 cites W2023205960 @default.
• W4288366249 cites W2026006003 @default.
• W4288366249 cites W2051322058 @default.
• W4288366249 cites W2099107563 @default.
• W4288366249 cites W2110065044 @default.
• W4288366249 cites W2152885278 @default.
• W4288366249 cites W2161163382 @default.
• W4288366249 cites W2166121267 @default.
• W4288366249 cites W2179438025 @default.
• W4288366249 cites W2401404581 @default.
• W4288366249 cites W253646976 @default.
• W4288366249 cites W2749493208 @default.
• W4288366249 cites W2767984705 @default.
• W4288366249 cites W2768716840 @default.
• W4288366249 cites W2769542288 @default.
• W4288366249 cites W2783644856 @default.
• W4288366249 cites W2788908087 @default.
• W4288366249 cites W2809048372 @default.
• W4288366249 cites W2904250115 @default.
• W4288366249 cites W2930816179 @default.
• W4288366249 cites W2950612336 @default.
• W4288366249 cites W2953200221 @default.
• W4288366249 cites W2975619549 @default.
• W4288366249 cites W2981036400 @default.
• W4288366249 cites W3000731297 @default.
• W4288366249 cites W4299542564 @default.
• W4288366249 cites W755741475 @default.
• W4288366249 doi "https://doi.org/10.48550/arxiv.1904.08937" @default.
• W4288366249 hasPublicationYear "2019" @default.
• W4288366249 type Work @default.
• W4288366249 citedByCount "0" @default.
• W4288366249 crossrefType "posted-content" @default.
• W4288366249 hasAuthorship W4288366249A5050320409 @default.
• W4288366249 hasAuthorship W4288366249A5070733780 @default.
• W4288366249 hasAuthorship W4288366249A5089088705 @default.
• W4288366249 hasBestOaLocation W42883662491 @default.
• W4288366249 hasConcept C104317684 @default.
• W4288366249 hasConcept C105795698 @default.
• W4288366249 hasConcept C116834253 @default.
• W4288366249 hasConcept C117251300 @default.
• W4288366249 hasConcept C122325731 @default.
• W4288366249 hasConcept C143121216 @default.
• W4288366249 hasConcept C15151743 @default.
• W4288366249 hasConcept C154945302 @default.
• W4288366249 hasConcept C18903297 @default.
• W4288366249 hasConcept C2776214188 @default.
• W4288366249 hasConcept C33923547 @default.
• W4288366249 hasConcept C41008148 @default.
• W4288366249 hasConcept C54355233 @default.
• W4288366249 hasConcept C60644358 @default.
• W4288366249 hasConcept C64869954 @default.
• W4288366249 hasConcept C70721500 @default.
• W4288366249 hasConcept C71640776 @default.
• W4288366249 hasConcept C77077793 @default.
• W4288366249 hasConcept C78458016 @default.
• W4288366249 hasConcept C86803240 @default.
• W4288366249 hasConceptScore W4288366249C104317684 @default.
• W4288366249 hasConceptScore W4288366249C105795698 @default.
• W4288366249 hasConceptScore W4288366249C116834253 @default.
• W4288366249 hasConceptScore W4288366249C117251300 @default.
• W4288366249 hasConceptScore W4288366249C122325731 @default.
• W4288366249 hasConceptScore W4288366249C143121216 @default.
• W4288366249 hasConceptScore W4288366249C15151743 @default.
• W4288366249 hasConceptScore W4288366249C154945302 @default.
• W4288366249 hasConceptScore W4288366249C18903297 @default.
• W4288366249 hasConceptScore W4288366249C2776214188 @default.
• W4288366249 hasConceptScore W4288366249C33923547 @default.
• W4288366249 hasConceptScore W4288366249C41008148 @default.
• W4288366249 hasConceptScore W4288366249C54355233 @default.
• W4288366249 hasConceptScore W4288366249C60644358 @default.
• W4288366249 hasConceptScore W4288366249C64869954 @default.
• W4288366249 hasConceptScore W4288366249C70721500 @default.
• W4288366249 hasConceptScore W4288366249C71640776 @default.
• W4288366249 hasConceptScore W4288366249C77077793 @default.
• W4288366249 hasConceptScore W4288366249C78458016 @default.
• W4288366249 hasConceptScore W4288366249C86803240 @default.
• W4288366249 hasLocation W42883662491 @default.
• W4288366249 hasOpenAccess W4288366249 @default.
• W4288366249 hasPrimaryLocation W42883662491 @default.
• W4288366249 hasRelatedWork W1222064643 @default.
• W4288366249 hasRelatedWork W2474302342 @default.
• W4288366249 hasRelatedWork W2947537008 @default.
• W4288366249 hasRelatedWork W2950447040 @default.
• W4288366249 hasRelatedWork W2969529002 @default.
• W4288366249 hasRelatedWork W2987445723 @default.
• W4288366249 hasRelatedWork W3131420028 @default.

• next