FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288425105> ?p ?o ?g. }

• W4288425105 abstract "Abstract Recent studies have suggested that transplant of hiPS-CMs is a promising approach for treating heart failure. However, the optimally clinical benefits have been hampered by the immature nature of the hiPS-CMs, and the hiPS-CMs-secreted proteins contributing to the repair of cardiomyocytes remain largely unidentified. Here, we established a saponin + compound optimally induced system to generate hiPS-CMs with stable functional attributes in vitro and transplanted in heart failure mice. Our study showed enhanced therapeutic effects of optimally induced hiPS-CMs by attenuating cardiac remodeling and dysfunction, these beneficial effects were concomitant with reduced cardiomyocytes death and increased angiogenesis. Moreover, the optimally induced hiPS-CMs could gathering to the injured heart and secret an abundant PDGF-BB. The reparative effect of the optimally induced hiPS-CMs in the hypoxia-injured HCMs was mimicked by PDGF-BB but inhibited by PDGF-BB neutralizing antibody, which was accompanied by the changed expression of p-PI3K and p-Akt proteins. It is highly possible that the PI3K/Akt pathway is regulated by the PDGF-BB secreted from the compound induced hiPS-CMs to achieve a longer lasting myocardial repair effect compared with the standard induced hiPS-CMs. Taken together, our data strongly implicate that the compound induced hiPS-CMs promote the recovery of injured hearts via paracrine action. In this process, the paracrine factor PDGF-BB derived from the compound induced hiPS-CMs reduces isoproterenol-induced adverse cardiac remodeling, which is associated with improved cardiac function, and these effects are mediated by the PI3K/Akt pathway, suggesting that the optimally induced hiPS-CMs may serve as a new promising cell therapy for clinical applications." @default.
• W4288425105 created "2022-07-29" @default.
• W4288425105 creator A5000330024 @default.
• W4288425105 creator A5027842326 @default.
• W4288425105 creator A5033474275 @default.
• W4288425105 creator A5036687874 @default.
• W4288425105 creator A5045470240 @default.
• W4288425105 creator A5057915184 @default.
• W4288425105 creator A5068080767 @default.
• W4288425105 creator A5073531557 @default.
• W4288425105 creator A5085548947 @default.
• W4288425105 date "2022-07-29" @default.
• W4288425105 modified "2023-10-02" @default.
• W4288425105 title "Cardiomyocytes induced from hiPSCs by well-defined compounds have therapeutic potential in heart failure by secreting PDGF-BB" @default.
• W4288425105 cites W189074344 @default.
• W4288425105 cites W1964120116 @default.
• W4288425105 cites W1968133243 @default.
• W4288425105 cites W1970288681 @default.
• W4288425105 cites W1986691722 @default.
• W4288425105 cites W1995173737 @default.
• W4288425105 cites W1997271589 @default.
• W4288425105 cites W1998777231 @default.
• W4288425105 cites W2010773563 @default.
• W4288425105 cites W2022759861 @default.
• W4288425105 cites W2025017052 @default.
• W4288425105 cites W2049439865 @default.
• W4288425105 cites W2054913890 @default.
• W4288425105 cites W2058099844 @default.
• W4288425105 cites W2066280170 @default.
• W4288425105 cites W2082973248 @default.
• W4288425105 cites W2093499017 @default.
• W4288425105 cites W2128141190 @default.
• W4288425105 cites W2148392331 @default.
• W4288425105 cites W2152865365 @default.
• W4288425105 cites W2168438265 @default.
• W4288425105 cites W2415616564 @default.
• W4288425105 cites W2460805176 @default.
• W4288425105 cites W2510906006 @default.
• W4288425105 cites W2528173482 @default.
• W4288425105 cites W2599501480 @default.
• W4288425105 cites W2601589642 @default.
• W4288425105 cites W2726239078 @default.
• W4288425105 cites W2888492075 @default.
• W4288425105 cites W2888880321 @default.
• W4288425105 cites W2888989090 @default.
• W4288425105 cites W2889601987 @default.
• W4288425105 cites W2897483054 @default.
• W4288425105 cites W2907789384 @default.
• W4288425105 cites W2990914781 @default.
• W4288425105 cites W315527216 @default.
• W4288425105 cites W4245465399 @default.
• W4288425105 cites W4255009698 @default.
• W4288425105 cites W4289253660 @default.
• W4288425105 cites W86870377 @default.
• W4288425105 doi "https://doi.org/10.1038/s41392-022-01045-4" @default.
• W4288425105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35902567" @default.
• W4288425105 hasPublicationYear "2022" @default.
• W4288425105 type Work @default.
• W4288425105 citedByCount "4" @default.
• W4288425105 countsByYear W42884251052022 @default.
• W4288425105 countsByYear W42884251052023 @default.
• W4288425105 crossrefType "journal-article" @default.
• W4288425105 hasAuthorship W4288425105A5000330024 @default.
• W4288425105 hasAuthorship W4288425105A5027842326 @default.
• W4288425105 hasAuthorship W4288425105A5033474275 @default.
• W4288425105 hasAuthorship W4288425105A5036687874 @default.
• W4288425105 hasAuthorship W4288425105A5045470240 @default.
• W4288425105 hasAuthorship W4288425105A5057915184 @default.
• W4288425105 hasAuthorship W4288425105A5068080767 @default.
• W4288425105 hasAuthorship W4288425105A5073531557 @default.
• W4288425105 hasAuthorship W4288425105A5085548947 @default.
• W4288425105 hasBestOaLocation W42884251051 @default.
• W4288425105 hasConcept C126322002 @default.
• W4288425105 hasConcept C170493617 @default.
• W4288425105 hasConcept C180361614 @default.
• W4288425105 hasConcept C2775960820 @default.
• W4288425105 hasConcept C2778198053 @default.
• W4288425105 hasConcept C2780394083 @default.
• W4288425105 hasConcept C502942594 @default.
• W4288425105 hasConcept C62478195 @default.
• W4288425105 hasConcept C71924100 @default.
• W4288425105 hasConcept C75217442 @default.
• W4288425105 hasConcept C7876069 @default.
• W4288425105 hasConcept C86554907 @default.
• W4288425105 hasConcept C86803240 @default.
• W4288425105 hasConcept C95444343 @default.
• W4288425105 hasConcept C98274493 @default.
• W4288425105 hasConceptScore W4288425105C126322002 @default.
• W4288425105 hasConceptScore W4288425105C170493617 @default.
• W4288425105 hasConceptScore W4288425105C180361614 @default.
• W4288425105 hasConceptScore W4288425105C2775960820 @default.
• W4288425105 hasConceptScore W4288425105C2778198053 @default.
• W4288425105 hasConceptScore W4288425105C2780394083 @default.
• W4288425105 hasConceptScore W4288425105C502942594 @default.
• W4288425105 hasConceptScore W4288425105C62478195 @default.
• W4288425105 hasConceptScore W4288425105C71924100 @default.
• W4288425105 hasConceptScore W4288425105C75217442 @default.
• W4288425105 hasConceptScore W4288425105C7876069 @default.
• W4288425105 hasConceptScore W4288425105C86554907 @default.
• W4288425105 hasConceptScore W4288425105C86803240 @default.

• next