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- W4288434593 abstract "Biofilm formation on endotracheal tubes (ETT) is an important factor in the development of ventilator-associated pneumonia (VAP). This work aimed to investigate the effectiveness of colistin (COL) against the early stages of biofilm formation by Pseudomonas aeruginosa. Two strategies were used: pre-conditioning the adhesion surfaces with COL before biofilm formation and growing biofilms in its presence. The combined effect of treating P. aeruginosa 24-hours old biofilms with Ciprofloxacin (CIP) or colistin (COL) on clean and COL-conditioned surfaces was also assessed. Random deposition of COL residues altered the physico-chemical properties of the adhesion surfaces and impaired biofilm formation. Moreover, as a consequence of the reduced amount of biofilms attached to COL conditioned surfaces, adhered cells became more exposed to the subsequent action of CIP or COL, suggesting a combined outcome of prophylactic and therapeutic COL-based strategies. Results highlighted the promising use of COL to prevent the establishment of biofilms on ETT." @default.
- W4288434593 created "2022-07-29" @default.
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- W4288434593 date "2022-07-03" @default.
- W4288434593 modified "2023-09-28" @default.
- W4288434593 title "Colistin conditioning surfaces combined with antimicrobial treatment to prevent ventilator-associated infections" @default.
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- W4288434593 doi "https://doi.org/10.1080/08927014.2022.2088284" @default.
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