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- W4288434597 endingPage "785" @default.
- W4288434597 startingPage "717" @default.
- W4288434597 abstract "Proteases are signaling molecules that specifically control cellular functions by cleaving protease-activated receptors (PARs). The four known PARs are members of the large family of G protein-coupled receptors. These transmembrane receptors control most physiological and pathological processes and are the target of a large proportion of therapeutic drugs. Signaling proteases include enzymes from the circulation; from immune, inflammatory epithelial, and cancer cells; as well as from commensal and pathogenic bacteria. Advances in our understanding of the structure and function of PARs provide insights into how diverse proteases activate these receptors to regulate physiological and pathological processes in most tissues and organ systems. The realization that proteases and PARs are key mediators of disease, coupled with advances in understanding the atomic level structure of PARs and their mechanisms of signaling in subcellular microdomains, has spurred the development of antagonists, some of which have advanced to the clinic. Herein we review the discovery, structure, and function of this receptor system, highlight the contribution of PARs to homeostatic control, and discuss the potential of PAR antagonists for the treatment of major diseases." @default.
- W4288434597 created "2022-07-29" @default.
- W4288434597 creator A5002405971 @default.
- W4288434597 creator A5015929707 @default.
- W4288434597 creator A5017948557 @default.
- W4288434597 creator A5082201331 @default.
- W4288434597 date "2023-01-01" @default.
- W4288434597 modified "2023-09-26" @default.
- W4288434597 title "Protease-activated receptors in health and disease" @default.
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