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- W4288436705 abstract "Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes transform and metabolize dietary- and host-derived molecules generating a diverse group of metabolites with local and systemic effects. The bi-directional communication between brain and the microbes residing in the gut, the so-called gut-brain axis, consists of a network of immunological, neuronal, and endocrine signaling pathways. Although the full variety of mechanisms of the gut-brain crosstalk is yet to be established, the existing data demonstrates that a single metabolite or its derivatives are likely among the key inductors within the gut-brain axis communication. However, more research is needed to understand the molecular mechanisms underlying how gut microbiota associated metabolites alter brain functions, and to examine if different interventional approaches targeting the gut microbiota could be used in prevention and treatment of neurological disorders, as reviewed herein.Abbreviations:4-EPS 4-ethylphenylsulfate; 5-AVA(B) 5-aminovaleric acid (betaine); Aβ Amyloid beta protein; AhR Aryl hydrocarbon receptor; ASD Autism spectrum disorder; BBB Blood-brain barrier; BDNF Brain-derived neurotrophic factor; CNS Central nervous system; GABA ɣ-aminobutyric acid; GF Germ-free; MIA Maternal immune activation; SCFA Short-chain fatty acid; 3M-4-TMAB 3-methyl-4-(trimethylammonio)butanoate; 4-TMAP 4-(trimethylammonio)pentanoate; TMA(O) Trimethylamine(-N-oxide); TUDCA Tauroursodeoxycholic acid; ZO Zonula occludens proteins." @default.
- W4288436705 created "2022-07-29" @default.
- W4288436705 creator A5005137352 @default.
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- W4288436705 creator A5072935938 @default.
- W4288436705 creator A5074921706 @default.
- W4288436705 date "2022-07-28" @default.
- W4288436705 modified "2023-10-11" @default.
- W4288436705 title "Microbiota-derived metabolites as drivers of gut–brain communication" @default.
- W4288436705 cites W1515023627 @default.
- W4288436705 cites W1797578063 @default.
- W4288436705 cites W1941562583 @default.
- W4288436705 cites W1965854886 @default.
- W4288436705 cites W1973217994 @default.
- W4288436705 cites W1976544976 @default.
- W4288436705 cites W1977219992 @default.
- W4288436705 cites W1978170677 @default.
- W4288436705 cites W1987459626 @default.
- W4288436705 cites W1993359155 @default.
- W4288436705 cites W1994802618 @default.
- W4288436705 cites W1995037165 @default.
- W4288436705 cites W1996441448 @default.
- W4288436705 cites W1997589613 @default.
- W4288436705 cites W1997608252 @default.
- W4288436705 cites W2000183088 @default.
- W4288436705 cites W2001725826 @default.
- W4288436705 cites W2002852362 @default.
- W4288436705 cites W2003342633 @default.
- W4288436705 cites W2005971787 @default.
- W4288436705 cites W2013582450 @default.
- W4288436705 cites W2014632252 @default.
- W4288436705 cites W2016076695 @default.
- W4288436705 cites W2020188629 @default.
- W4288436705 cites W2027187941 @default.
- W4288436705 cites W2030500910 @default.
- W4288436705 cites W2033386838 @default.
- W4288436705 cites W2035612381 @default.
- W4288436705 cites W2041058405 @default.
- W4288436705 cites W2042394891 @default.
- W4288436705 cites W2047668501 @default.
- W4288436705 cites W2051089741 @default.
- W4288436705 cites W2051923694 @default.
- W4288436705 cites W2052644645 @default.
- W4288436705 cites W2055493228 @default.
- W4288436705 cites W2060185417 @default.
- W4288436705 cites W2061631433 @default.
- W4288436705 cites W2066410861 @default.
- W4288436705 cites W2070153784 @default.
- W4288436705 cites W2072016770 @default.
- W4288436705 cites W2074647381 @default.
- W4288436705 cites W2076500913 @default.
- W4288436705 cites W2080763530 @default.
- W4288436705 cites W2082548421 @default.
- W4288436705 cites W2087243986 @default.
- W4288436705 cites W2091685843 @default.
- W4288436705 cites W2099594801 @default.
- W4288436705 cites W2100404177 @default.
- W4288436705 cites W2101147266 @default.
- W4288436705 cites W2109113634 @default.
- W4288436705 cites W2109332387 @default.
- W4288436705 cites W2113822705 @default.
- W4288436705 cites W2117029190 @default.
- W4288436705 cites W2119429325 @default.
- W4288436705 cites W2122321808 @default.
- W4288436705 cites W2126795224 @default.
- W4288436705 cites W2134254908 @default.
- W4288436705 cites W2137979078 @default.
- W4288436705 cites W2140366570 @default.
- W4288436705 cites W2142336938 @default.
- W4288436705 cites W2144133378 @default.
- W4288436705 cites W2150381557 @default.
- W4288436705 cites W2150981896 @default.
- W4288436705 cites W2153537282 @default.
- W4288436705 cites W2155134319 @default.
- W4288436705 cites W2155897723 @default.
- W4288436705 cites W2162871918 @default.
- W4288436705 cites W2164342861 @default.
- W4288436705 cites W2168842536 @default.
- W4288436705 cites W2188593832 @default.
- W4288436705 cites W2191644128 @default.
- W4288436705 cites W2211887163 @default.
- W4288436705 cites W2288655475 @default.
- W4288436705 cites W2298077113 @default.
- W4288436705 cites W2302886547 @default.
- W4288436705 cites W2341006644 @default.
- W4288436705 cites W2345604850 @default.
- W4288436705 cites W2350644376 @default.
- W4288436705 cites W2468315138 @default.
- W4288436705 cites W2468501494 @default.
- W4288436705 cites W2469798172 @default.
- W4288436705 cites W2482792965 @default.
- W4288436705 cites W2508485654 @default.
- W4288436705 cites W2516751998 @default.
- W4288436705 cites W2517534055 @default.
- W4288436705 cites W2546849981 @default.
- W4288436705 cites W2558041282 @default.
- W4288436705 cites W2581406049 @default.