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- W4288451368 abstract "The efficacy of adjuvant systemic therapy after surgical resection remains unsatisfactory; therefore, a new treatment strategy is required. We aimed to examine the efficacy of adjuvant immune-cell therapy using activated T lymphocytes with or without dendritic cell vaccination in combination with standard adjuvant systemic therapies in terms of the survival of patients with solid tumors, such as lung, gastric, pancreatic, colorectal, and breast cancers.A total of 141 patients with solid tumors were enrolled in this study. The correlation of overall survival and disease-free survival with various clinical factors such as age, sex, performance status score, clinical stage, treatment strategies, and vital status was investigated by univariate and multivariate analyses.Multivariate analysis revealed that a performance status score of 0 was a favorable prognostic factor in the full analysis set of solid tumors (HR=0.209, 95%CI=0.065-0.676, p=0.0089) and might be the indication for immune-cell therapy in the adjuvant setting.Adjuvant immune-cell therapy combined with other systemic therapies would potentially provide a survival benefit in patients with solid tumors." @default.
- W4288451368 created "2022-07-29" @default.
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- W4288451368 date "2022-07-26" @default.
- W4288451368 modified "2023-09-27" @default.
- W4288451368 title "Efficacy of Adjuvant Immune-cell Therapy Combined With Systemic Therapy for Solid Tumors" @default.
- W4288451368 doi "https://doi.org/10.21873/anticanres.15918" @default.
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