Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288451750> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4288451750 endingPage "36" @default.
- W4288451750 startingPage "25" @default.
- W4288451750 abstract "Objective: The present study aimed to evaluate the hypoglycemic and hypolipidemic activities of methanolic leaf extract of Garcinia gummi-gutta Linn. by HFD with low dose STZ induced T2DM on rats.
 Materials and Methods: The animals were divided into five groups of six animals, and HFD was induced for 8 weeks. After 4th week of HFD treatment, type-II diabetes was induced by a single dose of 35mg/kg (i.p) STZ, hyperglycemia was confirmed by the elevated levels of blood glucose determined at 72h and the animals with blood glucose concentration (< 250mg/dl) were used for the study. The In vitro anti-diabetic activity was done by the DNS method.
 Results: The In vitro anti-diabetic activity by α-amylase inhibition activity by DNS method was very mild as compared to Acarbose and the IC50 value of Acarbose was very low (170.84µg/ml) than MEGG (1989.59µg/ml). However, potent In vivo anti-diabetic activity (P<0.001) was observed after induction HFD with low dose STZ induced T2DM rats at the end of the 8th week, blood sugar level for MEGG high dose (173.40 ± 14.9mg/dl) was found to be almost same as that of standard drug Glibenclamide (164.60 ± 3.21mg/dl) as compared to control (287.90 ± 1.52). The lipid profile of the study showed a marked increase in TC, LDL, TG, and reduction in HDL in HFD with low dose STZ diabetic rats, whereas in MEGG and standard drugs treated by Glibenclamide were found to be substantially decreased and a fair amount of improvement in HDL level (P<0.001). Histologically, focal necrosis was observed in the diabetic rat pancreas whereas on standard and test mild and no evidence of necrosis were observed respectively, similar positive results were found in liver and adipocyte histology for standard and test groups against the HFD with STZ-induced group
 Conclusion: Therefore MEGG possesses potent In vivo anti-diabetic effect as well as hypolipidemic effect and therefore MEGG might be a potent phytochemical alternative to prevent and treat T2DM and atherosclerosis and also to reduce its associated complications." @default.
- W4288451750 created "2022-07-29" @default.
- W4288451750 creator A5024483592 @default.
- W4288451750 creator A5077052516 @default.
- W4288451750 date "2022-07-26" @default.
- W4288451750 modified "2023-10-18" @default.
- W4288451750 title "Evaluation of Hypoglycemic and Hypolipidemic Activities of Methanolic Leaf Extract of Garcinia gummi-gutta Linn by HFD with Low Dose STZ Induced Type II Diabetes Mellitus on Rats" @default.
- W4288451750 doi "https://doi.org/10.9734/jpri/2022/v34i45b36365" @default.
- W4288451750 hasPublicationYear "2022" @default.
- W4288451750 type Work @default.
- W4288451750 citedByCount "0" @default.
- W4288451750 crossrefType "journal-article" @default.
- W4288451750 hasAuthorship W4288451750A5024483592 @default.
- W4288451750 hasAuthorship W4288451750A5077052516 @default.
- W4288451750 hasBestOaLocation W42884517501 @default.
- W4288451750 hasConcept C126322002 @default.
- W4288451750 hasConcept C134018914 @default.
- W4288451750 hasConcept C185592680 @default.
- W4288451750 hasConcept C202751555 @default.
- W4288451750 hasConcept C2776617576 @default.
- W4288451750 hasConcept C2777752497 @default.
- W4288451750 hasConcept C2778163477 @default.
- W4288451750 hasConcept C2778270857 @default.
- W4288451750 hasConcept C2778913445 @default.
- W4288451750 hasConcept C2779768347 @default.
- W4288451750 hasConcept C2780485761 @default.
- W4288451750 hasConcept C2910068830 @default.
- W4288451750 hasConcept C55493867 @default.
- W4288451750 hasConcept C555293320 @default.
- W4288451750 hasConcept C556039675 @default.
- W4288451750 hasConcept C71924100 @default.
- W4288451750 hasConcept C98274493 @default.
- W4288451750 hasConceptScore W4288451750C126322002 @default.
- W4288451750 hasConceptScore W4288451750C134018914 @default.
- W4288451750 hasConceptScore W4288451750C185592680 @default.
- W4288451750 hasConceptScore W4288451750C202751555 @default.
- W4288451750 hasConceptScore W4288451750C2776617576 @default.
- W4288451750 hasConceptScore W4288451750C2777752497 @default.
- W4288451750 hasConceptScore W4288451750C2778163477 @default.
- W4288451750 hasConceptScore W4288451750C2778270857 @default.
- W4288451750 hasConceptScore W4288451750C2778913445 @default.
- W4288451750 hasConceptScore W4288451750C2779768347 @default.
- W4288451750 hasConceptScore W4288451750C2780485761 @default.
- W4288451750 hasConceptScore W4288451750C2910068830 @default.
- W4288451750 hasConceptScore W4288451750C55493867 @default.
- W4288451750 hasConceptScore W4288451750C555293320 @default.
- W4288451750 hasConceptScore W4288451750C556039675 @default.
- W4288451750 hasConceptScore W4288451750C71924100 @default.
- W4288451750 hasConceptScore W4288451750C98274493 @default.
- W4288451750 hasLocation W42884517501 @default.
- W4288451750 hasOpenAccess W4288451750 @default.
- W4288451750 hasPrimaryLocation W42884517501 @default.
- W4288451750 hasRelatedWork W1597823136 @default.
- W4288451750 hasRelatedWork W2015481685 @default.
- W4288451750 hasRelatedWork W2046812812 @default.
- W4288451750 hasRelatedWork W2273504969 @default.
- W4288451750 hasRelatedWork W2592258869 @default.
- W4288451750 hasRelatedWork W3005490443 @default.
- W4288451750 hasRelatedWork W3010718286 @default.
- W4288451750 hasRelatedWork W3087926679 @default.
- W4288451750 hasRelatedWork W4288451750 @default.
- W4288451750 hasRelatedWork W2239492991 @default.
- W4288451750 isParatext "false" @default.
- W4288451750 isRetracted "false" @default.
- W4288451750 workType "article" @default.