FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288455198> ?p ?o ?g. }

• W4288455198 endingPage "2325967121S0058" @default.
• W4288455198 startingPage "2325967121S0058" @default.
• W4288455198 abstract "Objectives: Osteochondral allograft transplantation for cartilage defects of the knee has demonstrated excellent long-term clinical outcomes and survival, which largely depends on successful graft osseointegration. Biologics have been suggested as a viable adjunct to enhance successful healing in several musculoskeletal applications. In the context of OCA, early results have suggested that BMAC may improve cellular repopulation and viability within the osseus portion of an implanted graft. However, few clinical studies to date have investigated the impact of BMAC on patient outcomes following OCA. The purpose of this study was to investigate the effect of bone marrow aspirate concentrate (BMAC) on osseointegration and patient-reported outcome metrics (PROMs) after osteochondral allograft transplantation in a prospective, randomized controlled single-blinded trial. Methods: Patients undergoing osteochondral allograft transplantation of the knee were consented and enrolled. Prior to surgery, patients were randomized into either the BMAC or sham incision groups. In the BMAC group, the osteochondral allograft plug was soaked in BMAC for a minimum of 2 minutes prior to implantation. All patients underwent postoperative computed tomography (CT) scanning at 6 months postoperatively and completed PROMs preoperatively, 6 months, and 1 year postoperatively. Two board-eligible orthopaedic surgeons blinded to treatment allocation independently assessed and graded each CT according to the ACTOCA system proposed by Gelber et al. Results: Thirty-six patients enrolled between April 2018 to December 2020 (17 female, 19 male) were included for analysis. There were no significant differences between the BMAC and non-BMAC groups in graft signal density (Grader 1: p=0.283, Grader 2: p=0.467), osseous integration (both graders: p=0.489), surface percentage with discernible cleft (Grader 1: 0.287, Grader 2: 0.469), or intra-articular fragments (Grader 1: p=0.617, Grader 2: p=0.810) (Table 1). A significantly greater number of patients receiving BMAC demonstrating cystic changes <3 mm (Grader 1: p=0.015, Grader 2: p=0.05) (Figure 1). At 1 year, BMAC patients reported significantly better WOMAC Pain (87.82±14.26 vs 75.80±15.56, p=0.043) and trended towards improved PROMIS Pain (54.14±8.31 vs 61.79±5.24, p=0.09). Conclusions: Patients receiving BMAC soaked OCA grafts demonstrated no difference from controls with respect to graft signal intensity, osseous integration, intra-articular fragments, or discernible graft-host clefts at 6-months postoperatively. BMAC patients had a significantly greater occurrence of small (<3 mm) cystic changes. At 1 year, BMAC patients reported significantly less pain than controls on WOMAC Pain, with similar trends on PROMIS Pain Interference. [Table: see text][Figure: see text]" @default.
• W4288455198 created "2022-07-29" @default.
• W4288455198 creator A5007965673 @default.
• W4288455198 creator A5042643030 @default.
• W4288455198 creator A5047386051 @default.
• W4288455198 creator A5048558888 @default.
• W4288455198 creator A5063333390 @default.
• W4288455198 creator A5064391561 @default.
• W4288455198 creator A5065711124 @default.
• W4288455198 creator A5084967312 @default.
• W4288455198 date "2022-07-01" @default.
• W4288455198 modified "2023-09-30" @default.
• W4288455198 title "Paper 18: Effect of Bone Marrow Aspirate Concentrate on Osteochondral Allograft Transplantation Incorporation: A Prospective, Randomized, Single Blind Investigation" @default.
• W4288455198 doi "https://doi.org/10.1177/2325967121s00582" @default.
• W4288455198 hasPublicationYear "2022" @default.
• W4288455198 type Work @default.
• W4288455198 citedByCount "1" @default.
• W4288455198 countsByYear W42884551982023 @default.
• W4288455198 crossrefType "journal-article" @default.
• W4288455198 hasAuthorship W4288455198A5007965673 @default.
• W4288455198 hasAuthorship W4288455198A5042643030 @default.
• W4288455198 hasAuthorship W4288455198A5047386051 @default.
• W4288455198 hasAuthorship W4288455198A5048558888 @default.
• W4288455198 hasAuthorship W4288455198A5063333390 @default.
• W4288455198 hasAuthorship W4288455198A5064391561 @default.
• W4288455198 hasAuthorship W4288455198A5065711124 @default.
• W4288455198 hasAuthorship W4288455198A5084967312 @default.
• W4288455198 hasBestOaLocation W42884551981 @default.
• W4288455198 hasConcept C126322002 @default.
• W4288455198 hasConcept C141071460 @default.
• W4288455198 hasConcept C151730666 @default.
• W4288455198 hasConcept C168563851 @default.
• W4288455198 hasConcept C2779343474 @default.
• W4288455198 hasConcept C2780007613 @default.
• W4288455198 hasConcept C2908745798 @default.
• W4288455198 hasConcept C2911091166 @default.
• W4288455198 hasConcept C71924100 @default.
• W4288455198 hasConcept C86803240 @default.
• W4288455198 hasConceptScore W4288455198C126322002 @default.
• W4288455198 hasConceptScore W4288455198C141071460 @default.
• W4288455198 hasConceptScore W4288455198C151730666 @default.
• W4288455198 hasConceptScore W4288455198C168563851 @default.
• W4288455198 hasConceptScore W4288455198C2779343474 @default.
• W4288455198 hasConceptScore W4288455198C2780007613 @default.
• W4288455198 hasConceptScore W4288455198C2908745798 @default.
• W4288455198 hasConceptScore W4288455198C2911091166 @default.
• W4288455198 hasConceptScore W4288455198C71924100 @default.
• W4288455198 hasConceptScore W4288455198C86803240 @default.
• W4288455198 hasIssue "7_suppl5" @default.
• W4288455198 hasLocation W42884551981 @default.
• W4288455198 hasLocation W42884551982 @default.
• W4288455198 hasOpenAccess W4288455198 @default.
• W4288455198 hasPrimaryLocation W42884551981 @default.
• W4288455198 hasRelatedWork W1586374228 @default.
• W4288455198 hasRelatedWork W2003938723 @default.
• W4288455198 hasRelatedWork W2047967234 @default.
• W4288455198 hasRelatedWork W2089201504 @default.
• W4288455198 hasRelatedWork W2118496982 @default.
• W4288455198 hasRelatedWork W2364998975 @default.
• W4288455198 hasRelatedWork W2369162477 @default.
• W4288455198 hasRelatedWork W2439875401 @default.
• W4288455198 hasRelatedWork W4238867864 @default.
• W4288455198 hasRelatedWork W2525756941 @default.
• W4288455198 hasVolume "10" @default.
• W4288455198 isParatext "false" @default.
• W4288455198 isRetracted "false" @default.
• W4288455198 workType "article" @default.