FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288456734> ?p ?o ?g. }

• W4288456734 endingPage "152079" @default.
• W4288456734 startingPage "152079" @default.
• W4288456734 abstract "Antioxidants, as scavengers of free radicals, have been proposed as potential targets for the prevention and treatment of rheumatoid arthritis (RA), however, the causal associations between antioxidants and RA are still in debate.This study aims to evaluate this causal association with two-sample Mendelian randomization (MR) analysis.Inverse-variance weighted was used as the major analysis method of MR. Genetic variants associated with dietary antioxidants including vitamin E (α- and γ-tocopherol), β-carotene, lycopene, vitamin C (L-ascorbic acid or ascorbate), and retinol, and their circulating metabolites were used as instrumental variables. The causal effects of the antioxidants were assessed in genome-wide association study datasets of RA from a previous publication (Okada Y. et al.) and Finngen consortium and combined with meta-analysis.We observed that the levels of circulating retinol metabolite negatively correlates with the risk of overall RA in the dataset from Okada Y. et al. (odds ratio [OR]=0.952, 95% confidence interval [CI]=0.911-0.996, p = 0.031) and Finngen (OR=0.946, 95%CI=0.903-0.991, p = 0.020). The causal association remained consistent in the meta-analysis (OR=0.949, 95%CI=0.919-0.98, p = 0.002). Increased levels of circulating retinol metabolite also suggestively decreased the risk of seropositive RA (OR=0.936, 95%CI=0.884-0.992, p = 0.025) but not seronegative RA (OR=0.996, 95%CI=0.921-1.076, p = 0.913). No causal effects of other dietary antioxidants on RA were identified in our analyses.Our study suggested a protective effect of circulating retinol metabolites, but not other antioxidants, on overall RA and seropositive RA. Dietary supplementation of retinol may be an effective measure for the primary prevention of RA." @default.
• W4288456734 created "2022-07-29" @default.
• W4288456734 creator A5041954647 @default.
• W4288456734 creator A5060028094 @default.
• W4288456734 creator A5077994592 @default.
• W4288456734 date "2022-10-01" @default.
• W4288456734 modified "2023-10-16" @default.
• W4288456734 title "Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: A Mendelian randomization study" @default.
• W4288456734 cites W1494675041 @default.
• W4288456734 cites W1791199433 @default.
• W4288456734 cites W1968649812 @default.
• W4288456734 cites W1983634320 @default.
• W4288456734 cites W1989568128 @default.
• W4288456734 cites W1989590412 @default.
• W4288456734 cites W1995671655 @default.
• W4288456734 cites W1998271078 @default.
• W4288456734 cites W1998716086 @default.
• W4288456734 cites W2003413100 @default.
• W4288456734 cites W2031005163 @default.
• W4288456734 cites W2032221360 @default.
• W4288456734 cites W2039153962 @default.
• W4288456734 cites W2059243963 @default.
• W4288456734 cites W2066812493 @default.
• W4288456734 cites W2098927306 @default.
• W4288456734 cites W2108562382 @default.
• W4288456734 cites W2109349820 @default.
• W4288456734 cites W2110826367 @default.
• W4288456734 cites W2118008714 @default.
• W4288456734 cites W2124295107 @default.
• W4288456734 cites W2138775791 @default.
• W4288456734 cites W2144342799 @default.
• W4288456734 cites W2148357767 @default.
• W4288456734 cites W2151096860 @default.
• W4288456734 cites W2163108977 @default.
• W4288456734 cites W2167979104 @default.
• W4288456734 cites W2255715879 @default.
• W4288456734 cites W2313462881 @default.
• W4288456734 cites W2324862792 @default.
• W4288456734 cites W2395249393 @default.
• W4288456734 cites W2528302205 @default.
• W4288456734 cites W2594275078 @default.
• W4288456734 cites W2614566443 @default.
• W4288456734 cites W2736634847 @default.
• W4288456734 cites W2795553077 @default.
• W4288456734 cites W2803072880 @default.
• W4288456734 cites W2809017571 @default.
• W4288456734 cites W3005979889 @default.
• W4288456734 cites W3017239806 @default.
• W4288456734 cites W3037151325 @default.
• W4288456734 cites W3049163120 @default.
• W4288456734 cites W3115180143 @default.
• W4288456734 cites W3120603588 @default.
• W4288456734 cites W3153718873 @default.
• W4288456734 cites W3204219730 @default.
• W4288456734 cites W3210406414 @default.
• W4288456734 cites W4200179860 @default.
• W4288456734 cites W4200291825 @default.
• W4288456734 cites W4211111012 @default.
• W4288456734 cites W4241917186 @default.
• W4288456734 doi "https://doi.org/10.1016/j.semarthrit.2022.152079" @default.
• W4288456734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35932494" @default.
• W4288456734 hasPublicationYear "2022" @default.
• W4288456734 type Work @default.
• W4288456734 citedByCount "1" @default.
• W4288456734 countsByYear W42884567342023 @default.
• W4288456734 crossrefType "journal-article" @default.
• W4288456734 hasAuthorship W4288456734A5041954647 @default.
• W4288456734 hasAuthorship W4288456734A5060028094 @default.
• W4288456734 hasAuthorship W4288456734A5077994592 @default.
• W4288456734 hasConcept C104317684 @default.
• W4288456734 hasConcept C126322002 @default.
• W4288456734 hasConcept C135763542 @default.
• W4288456734 hasConcept C156957248 @default.
• W4288456734 hasConcept C2776940978 @default.
• W4288456734 hasConcept C2777477808 @default.
• W4288456734 hasConcept C2777575956 @default.
• W4288456734 hasConcept C2779573558 @default.
• W4288456734 hasConcept C2779901538 @default.
• W4288456734 hasConcept C2986274086 @default.
• W4288456734 hasConcept C2993967602 @default.
• W4288456734 hasConcept C31903555 @default.
• W4288456734 hasConcept C42407357 @default.
• W4288456734 hasConcept C44249647 @default.
• W4288456734 hasConcept C54355233 @default.
• W4288456734 hasConcept C71924100 @default.
• W4288456734 hasConcept C86803240 @default.
• W4288456734 hasConcept C90924648 @default.
• W4288456734 hasConceptScore W4288456734C104317684 @default.
• W4288456734 hasConceptScore W4288456734C126322002 @default.
• W4288456734 hasConceptScore W4288456734C135763542 @default.
• W4288456734 hasConceptScore W4288456734C156957248 @default.
• W4288456734 hasConceptScore W4288456734C2776940978 @default.
• W4288456734 hasConceptScore W4288456734C2777477808 @default.
• W4288456734 hasConceptScore W4288456734C2777575956 @default.
• W4288456734 hasConceptScore W4288456734C2779573558 @default.
• W4288456734 hasConceptScore W4288456734C2779901538 @default.
• W4288456734 hasConceptScore W4288456734C2986274086 @default.
• W4288456734 hasConceptScore W4288456734C2993967602 @default.

• next