Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288457156> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4288457156 endingPage "201091" @default.
- W4288457156 startingPage "201091" @default.
- W4288457156 abstract "Many single nucleotide polymorphisms (SNPs) in the cytokine genes are reported to be associated with altered host susceptibility to tuberculosis (TB). Interleukin (IL)-12 has crucial role in immunity against Mycobacterium tuberculosis (MTB), the causative organism of TB. IL-12 is a key cytokine required for the release of IFN-γ by NK and Th1 cells, which is regarded as pivotal cytokine against TB. IL-12 has two subunits IL-p35 and IL-12p40 encoded by IL-12A and IL-12B gene respectively. Present study was designed for evaluating the association of rs3212220 G/T SNP of IL-12B and to check plasma levels of IL-12p40 in TB patients from population of Punjab, India. This case-control study was conducted on 300 TB patients and 150 normal healthy controls (NHCs) . Genotyping of selected SNP of IL-12B was done by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. Plasma levels of IL-12p40 were measured by enzyme linked immunosorbent assay (ELISA). Statistical significance level was calculated at 0.05. No statistically significant difference was found between genotypic and allelic frequencies of rs3212220 G/T SNP of IL-12B among TB patients and NHCs. IL-12p40 levels were found to significantly elevated in TB patients when compared with NHCs ( p < 0.0001). These levels declined with the course of anti-tuberculosis therapy (ATT). GG and GT genotypes found to be associated with increased levels the IL-12p40 in TB patients when compared to NHCs." @default.
- W4288457156 created "2022-07-29" @default.
- W4288457156 creator A5033807293 @default.
- W4288457156 creator A5037469337 @default.
- W4288457156 creator A5052806910 @default.
- W4288457156 creator A5060231801 @default.
- W4288457156 creator A5087829468 @default.
- W4288457156 date "2022-12-01" @default.
- W4288457156 modified "2023-09-23" @default.
- W4288457156 title "Association of rs3212220 G/T single nucleotide polymorphism of IL-12B with tuberculosis in the population of Punjab, India" @default.
- W4288457156 cites W1723545928 @default.
- W4288457156 cites W1765079284 @default.
- W4288457156 cites W1905061145 @default.
- W4288457156 cites W1983986500 @default.
- W4288457156 cites W1995691015 @default.
- W4288457156 cites W2009219530 @default.
- W4288457156 cites W2033732585 @default.
- W4288457156 cites W2057991224 @default.
- W4288457156 cites W2058275239 @default.
- W4288457156 cites W2064063117 @default.
- W4288457156 cites W2088183999 @default.
- W4288457156 cites W2100219680 @default.
- W4288457156 cites W2102156468 @default.
- W4288457156 cites W2103740237 @default.
- W4288457156 cites W2104341710 @default.
- W4288457156 cites W2110759326 @default.
- W4288457156 cites W2110888991 @default.
- W4288457156 cites W2132289929 @default.
- W4288457156 cites W2157438248 @default.
- W4288457156 cites W2164309428 @default.
- W4288457156 cites W2171049694 @default.
- W4288457156 cites W2171231066 @default.
- W4288457156 cites W2514999355 @default.
- W4288457156 cites W2602169678 @default.
- W4288457156 cites W2946867948 @default.
- W4288457156 cites W3133025128 @default.
- W4288457156 cites W4239937288 @default.
- W4288457156 doi "https://doi.org/10.1016/j.humgen.2022.201091" @default.
- W4288457156 hasPublicationYear "2022" @default.
- W4288457156 type Work @default.
- W4288457156 citedByCount "0" @default.
- W4288457156 crossrefType "journal-article" @default.
- W4288457156 hasAuthorship W4288457156A5033807293 @default.
- W4288457156 hasAuthorship W4288457156A5037469337 @default.
- W4288457156 hasAuthorship W4288457156A5052806910 @default.
- W4288457156 hasAuthorship W4288457156A5060231801 @default.
- W4288457156 hasAuthorship W4288457156A5087829468 @default.
- W4288457156 hasConcept C104317684 @default.
- W4288457156 hasConcept C135763542 @default.
- W4288457156 hasConcept C142724271 @default.
- W4288457156 hasConcept C149737253 @default.
- W4288457156 hasConcept C153209595 @default.
- W4288457156 hasConcept C2781069245 @default.
- W4288457156 hasConcept C2908647359 @default.
- W4288457156 hasConcept C54355233 @default.
- W4288457156 hasConcept C71924100 @default.
- W4288457156 hasConcept C86803240 @default.
- W4288457156 hasConcept C99454951 @default.
- W4288457156 hasConceptScore W4288457156C104317684 @default.
- W4288457156 hasConceptScore W4288457156C135763542 @default.
- W4288457156 hasConceptScore W4288457156C142724271 @default.
- W4288457156 hasConceptScore W4288457156C149737253 @default.
- W4288457156 hasConceptScore W4288457156C153209595 @default.
- W4288457156 hasConceptScore W4288457156C2781069245 @default.
- W4288457156 hasConceptScore W4288457156C2908647359 @default.
- W4288457156 hasConceptScore W4288457156C54355233 @default.
- W4288457156 hasConceptScore W4288457156C71924100 @default.
- W4288457156 hasConceptScore W4288457156C86803240 @default.
- W4288457156 hasConceptScore W4288457156C99454951 @default.
- W4288457156 hasFunder F4320320767 @default.
- W4288457156 hasLocation W42884571561 @default.
- W4288457156 hasOpenAccess W4288457156 @default.
- W4288457156 hasPrimaryLocation W42884571561 @default.
- W4288457156 hasRelatedWork W1663907732 @default.
- W4288457156 hasRelatedWork W1903732681 @default.
- W4288457156 hasRelatedWork W2015246629 @default.
- W4288457156 hasRelatedWork W2085192631 @default.
- W4288457156 hasRelatedWork W2112311229 @default.
- W4288457156 hasRelatedWork W2348076134 @default.
- W4288457156 hasRelatedWork W2358056150 @default.
- W4288457156 hasRelatedWork W2369766501 @default.
- W4288457156 hasRelatedWork W2374003810 @default.
- W4288457156 hasRelatedWork W2392819957 @default.
- W4288457156 hasVolume "34" @default.
- W4288457156 isParatext "false" @default.
- W4288457156 isRetracted "false" @default.
- W4288457156 workType "article" @default.