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- W4288459439 endingPage "R86" @default.
- W4288459439 startingPage "R75" @default.
- W4288459439 abstract "Trophectoderm is the first tissue to differentiate in the early mammalian embryo and is essential for hatching, implantation, and placentation. This review article discusses the roles of Ras homolog family members (RHO) and RHO-associated coiled-coil containing protein kinases (ROCK) in the molecular and cellular regulation of trophectoderm formation.The trophectoderm (TE) is the first tissue to differentiate during the preimplantation development of placental mammals. It constitutes the outer epithelial layer of the blastocyst and is responsible for hatching, uterine attachment, and placentation. Thus, its formation is the key initial step that enables the viviparity of mammals. Here, we first describe the general features of TE formation at the morphological and molecular levels. Prospective TE cells form an epithelial layer enclosing an expanding fluid-filled cavity by establishing the apical-basal cell polarity, intercellular junctions, microlumen, and osmotic gradient. A unique set of genes is expressed in TE that encode the transcription factors essential for the development of trophoblasts of the placenta upon implantation. TE-specific gene expressions are driven by the inhibition of HIPPO signaling, which is dependent on the prior establishment of the apical-basal polarity. We then discuss the specific roles of RHO and ROCK as essential regulators of TE formation. RHO and ROCK modulate the actomyosin cytoskeleton, apical-basal polarity, intercellular junctions, and HIPPO signaling, thereby orchestrating the epithelialization and gene expressions in TE. Knowledge of the molecular mechanisms underlying TE formation is crucial for assisted reproductive technologies in human and farm animals, as it provides foundation to help improve procedures for embryo handling and selection to achieve better reproductive outcomes." @default.
- W4288459439 created "2022-07-29" @default.
- W4288459439 creator A5072356526 @default.
- W4288459439 creator A5088570602 @default.
- W4288459439 date "2022-10-01" @default.
- W4288459439 modified "2023-10-03" @default.
- W4288459439 title "Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling" @default.
- W4288459439 cites W1519287420 @default.
- W4288459439 cites W1569511152 @default.
- W4288459439 cites W1597787921 @default.
- W4288459439 cites W1968062255 @default.
- W4288459439 cites W1968805416 @default.
- W4288459439 cites W1971377045 @default.
- W4288459439 cites W1978235872 @default.
- W4288459439 cites W1978424801 @default.
- W4288459439 cites W1979298412 @default.
- W4288459439 cites W1980426094 @default.
- W4288459439 cites W1986570767 @default.
- W4288459439 cites W1986944049 @default.
- W4288459439 cites W1990498979 @default.
- W4288459439 cites W2006612446 @default.
- W4288459439 cites W2007439698 @default.
- W4288459439 cites W2012305943 @default.
- W4288459439 cites W2040047177 @default.
- W4288459439 cites W2046587126 @default.
- W4288459439 cites W2049113047 @default.
- W4288459439 cites W2049484354 @default.
- W4288459439 cites W2053482584 @default.
- W4288459439 cites W2057340302 @default.
- W4288459439 cites W2066482548 @default.
- W4288459439 cites W2074877298 @default.
- W4288459439 cites W2088593944 @default.
- W4288459439 cites W2098094337 @default.
- W4288459439 cites W2115740579 @default.
- W4288459439 cites W2125336256 @default.
- W4288459439 cites W2130104786 @default.
- W4288459439 cites W2133362360 @default.
- W4288459439 cites W2139650361 @default.
- W4288459439 cites W2155917588 @default.
- W4288459439 cites W2170439599 @default.
- W4288459439 cites W2236437011 @default.
- W4288459439 cites W2284915381 @default.
- W4288459439 cites W2293098591 @default.
- W4288459439 cites W2316095770 @default.
- W4288459439 cites W2326134743 @default.
- W4288459439 cites W2395146274 @default.
- W4288459439 cites W2400903013 @default.
- W4288459439 cites W2419175294 @default.
- W4288459439 cites W2429042322 @default.
- W4288459439 cites W2461950106 @default.
- W4288459439 cites W2482879788 @default.
- W4288459439 cites W2511262363 @default.
- W4288459439 cites W2560143339 @default.
- W4288459439 cites W2587076303 @default.
- W4288459439 cites W2591350842 @default.
- W4288459439 cites W2733567312 @default.
- W4288459439 cites W2746281200 @default.
- W4288459439 cites W2756631046 @default.
- W4288459439 cites W2758838459 @default.
- W4288459439 cites W2759945688 @default.
- W4288459439 cites W2767203015 @default.
- W4288459439 cites W2769006120 @default.
- W4288459439 cites W2789772898 @default.
- W4288459439 cites W2792361010 @default.
- W4288459439 cites W2800655655 @default.
- W4288459439 cites W2802589812 @default.
- W4288459439 cites W2890183842 @default.
- W4288459439 cites W2892742564 @default.
- W4288459439 cites W2899641791 @default.
- W4288459439 cites W2913575242 @default.
- W4288459439 cites W2944099912 @default.
- W4288459439 cites W2944827312 @default.
- W4288459439 cites W2951612674 @default.
- W4288459439 cites W2952018947 @default.
- W4288459439 cites W2959814266 @default.
- W4288459439 cites W2965254992 @default.
- W4288459439 cites W2966429158 @default.
- W4288459439 cites W2980104037 @default.
- W4288459439 cites W2980321412 @default.
- W4288459439 cites W2980793885 @default.
- W4288459439 cites W2983057497 @default.
- W4288459439 cites W2983203819 @default.
- W4288459439 cites W2985582581 @default.
- W4288459439 cites W2990237704 @default.
- W4288459439 cites W2990607066 @default.
- W4288459439 cites W2990633857 @default.
- W4288459439 cites W2995464460 @default.
- W4288459439 cites W2996475925 @default.
- W4288459439 cites W3011815506 @default.
- W4288459439 cites W3033387848 @default.
- W4288459439 cites W3041001090 @default.
- W4288459439 cites W3044385274 @default.
- W4288459439 cites W3088405549 @default.
- W4288459439 cites W3112719934 @default.
- W4288459439 cites W3113898550 @default.
- W4288459439 cites W3128464926 @default.
- W4288459439 cites W3134989184 @default.
- W4288459439 cites W3135325607 @default.