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- W4288460839 endingPage "110610" @default.
- W4288460839 startingPage "110610" @default.
- W4288460839 abstract "Alzheimer's disease (AD) is a central nervous system disease characterised by degenerative cognitive dysfunction and memory loss. In a society where the global population is gradually ageing, the health threats and financial burdens caused by AD are becoming increasingly severe since AD often occurs in old age. With the in-depth study of AD, many new pathogenic mechanisms have been proposed, among which bidirectional communication between intestinal microbes and the brain has attracted widespread attention. The aetiology of inflammatory bowel disease (IBD) is related to the imbalance of the gut microbiota. Epidemiological investigations have shown that patients with IBD are more likely to suffer from AD. Targeting IBD as a potential AD treatment target has attracted considerable interest. Here, we reviewed the link between chronic intestinal inflammation and central nervous system inflammation and found that IBD patients had a higher risk of AD than non-IBD patients. Preclinical models based on AD also showed that IBD aggravated the condition of AD. We discussed possible biological links between AD and IBD, including the gut-brain axis, autoimmunity, and the gut microbiota. In addition, IBD-induced changes in intestinal microbial metabolites, such as short-chain fatty acids, bile acids, and tryptophan, which aggravate the development of AD, were also discussed." @default.
- W4288460839 created "2022-07-29" @default.
- W4288460839 creator A5013582226 @default.
- W4288460839 creator A5031306837 @default.
- W4288460839 creator A5072949609 @default.
- W4288460839 date "2022-12-01" @default.
- W4288460839 modified "2023-10-14" @default.
- W4288460839 title "Inflammatory bowel disease: A potential pathogenic factor of Alzheimer's disease" @default.
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