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• W4288473578 abstract "Besides synthetic drugs, a wide variety of medicinal plants have been used for the prevention and management of various liver disorders. Generally, plant therapies are well tolerated due to their lesser side effects. The aims and objectives of this review are to describe the drug therapies used for treating liver disorders as well as the most commonly used hepatoprotective plant-derived bioactive ingredients and their formulations employed for treating various liver pathologies. The extensive literature review was conducted using different databases such as ScienceDirect, SciFinder Scholar, Wiley Online Library, PubMed, ResearchGate, Google Scholar and Chemical Abstracts (until March 2021). Our literature searches showed that a wide array of plant products or plant extracts have been used in the folklore and traditional remedies for the prevention and management of liver disorders. The complex chemical structures of many isolated plant ingredients such as flavonoids, polyphenols, and steroid-type compounds have been determined using sophisticated analytical techniques. While the pharmacological and toxicological activities of many plant products have been tested in animal models, their underlying mechanism of action remains unknown. In this review, we will describe the hepatoprotective actions of the following plants and their bioactive components: Allium sativum, Allium hirtifolium, Andrographis paniculata, Apium graveolens, Asparagus racemosus, Berberis vulgaris, Curcuma longa, Emblica officinalis, Glycyrrhiza glabra, Marrubium vulgare, Nigella sativa, Phyllanthus niruri, Picrorhiza kurroa, Solanum nigrum, Swertia chirayita, Taraxacum officinale, oleanolic acid, Cliv-92, ursolic acid, berberine, proanthocyanidins, naringenin, silymarin, andrographolide, glycyrrhizin, curcumin, rhein, geniposide and resveratrol. There are challenges and opportunities for understanding the mechanism of action of the phytotherapies used for curing liver diseases as well as discovering new drug molecules useful for targeting different liver ailments. Combinations of traditional herbal remedies found to be safe and effective are also suggested as a possible cost-effective therapeutic tool to be tested in future researches aiming to unveil novel options to treat liver disorders in humans. However, well-designed, randomized, placebo-controlled, multicentre trials are needed to establish the long-term safety and efficacy as well the optimal dose schedules required for treating different liver disorders in humans." @default.
• W4288473578 created "2022-07-29" @default.
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• W4288473578 date "2022-01-01" @default.
• W4288473578 modified "2023-09-26" @default.
• W4288473578 title "The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review" @default.
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