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• W4288473630 endingPage "350" @default.
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• W4288473630 abstract "Nanostructured systems provide immense advantages not only in regard to delivery and release of drugs but also in their targeting potential. Such drug nanoconstructs either can be modified for receptor-mediated and site-specific targeting or can be used to regulate release of drugs, widely ranging from insoluble to highly soluble molecules, proteins and peptides to monoclonal antibodies, genes and small RNA. Nanoscale drug delivery systems can not only be fine-tuned for desired drug release kinetics and biodistribution but can also minimize the toxic effects, thereby enhancing the therapeutic index of a given drug. The domain of developing nanostructured drug delivery formulations has lately witnessed an enormous paradigm shift towards their methodical development. Promulgation of Quality-by-Design (QbD) guidance documents by the WHO, the US-FDA and other regulatory bodies has evidently influenced the manufacturing approach of such drug products, furnishing comprehensive understanding of the consequent drug products and pharmaceutical processes. Lately, a scientific approach, christened by the authors as “Formulation by Design (FbD)”, has been in vogue, devoted wholly to QbD-steered development of drug products. FbD strategy targets to harvest novel and cutting-edge systems utilizing thrifty resources of developmental time, manpower, materials and finances. A diversity of drug nanoconstructs has since been developed efficaciously as per FbD principles and testified in literature. The present manuscript tends to furnish coherent perspectives on the FbD terminology, methodology and applicability in developing several wide-ranging nanoconstructs, providing their contemporary updates from their academic, industrial and regulatory perspectives." @default.
• W4288473630 created "2022-07-29" @default.
• W4288473630 creator A5008834153 @default.
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• W4288473630 creator A5077567027 @default.
• W4288473630 date "2022-01-01" @default.
• W4288473630 modified "2023-09-28" @default.
• W4288473630 title "QbD-Steered Systematic Development of Drug Delivery Nanoconstructs: Vital Precepts, Retrospect and Prospects" @default.
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