Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288489069> ?p ?o ?g. }
- W4288489069 abstract "Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT) remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral sensing, we investigated the impact of common single-nucleotide polymorphisms (SNPs) located within TLR3 and TLR9 genes on the occurrence of overall and high-level (≥1,000 IU/ml) CMV infection in a cohort of 197 KT recipients. Homozygous carriers of the minor allele of TLR3 (rs3775291) had higher infection-free survival compared with reference allele carriers (60.0% for TT versus 42.3% for CC/CT genotypes; P -value = 0.050). Decreased infection-free survival was observed with the minor allele of TLR9 (rs352139) (38.2% for TC/CC versus 59.3% for TT genotypes; P -value = 0.004). After multivariable adjustment, the recessive protective effect of the TLR3 (rs3775291) TT genotype was confirmed (adjusted hazard ratio [aHR]: 0.327; 95% CI: 0.167–0.642; P -value = 0.001), as was the dominant risk-conferring effect of TLR9 (rs352139) TC/CC genotypes (aHR: 1.865; 95% CI: 1.170–2.972; P -value = 0.009). Carriers of the TLR9 (rs352139) TC/CC genotypes showed lower CMV-specific interferon-γ-producing CD4+ T-cell counts measured by intracellular cytokine staining compared with the TT genotype (median of 0.2 versus 0.7 cells/μl; P -value = 0.003). In conclusion, TLR3/TLR9 genotyping may inform CMV infection risk after KT." @default.
- W4288489069 created "2022-07-29" @default.
- W4288489069 creator A5011742361 @default.
- W4288489069 creator A5016258231 @default.
- W4288489069 creator A5028726117 @default.
- W4288489069 creator A5034427288 @default.
- W4288489069 creator A5041818001 @default.
- W4288489069 creator A5045536586 @default.
- W4288489069 creator A5050231608 @default.
- W4288489069 creator A5055789599 @default.
- W4288489069 creator A5062363608 @default.
- W4288489069 creator A5066044288 @default.
- W4288489069 creator A5072787889 @default.
- W4288489069 creator A5076286462 @default.
- W4288489069 creator A5081849372 @default.
- W4288489069 date "2022-07-29" @default.
- W4288489069 modified "2023-10-03" @default.
- W4288489069 title "Influence of single-nucleotide polymorphisms in TLR3 (rs3775291) and TLR9 (rs352139) on the risk of CMV infection in kidney transplant recipients" @default.
- W4288489069 cites W1586769637 @default.
- W4288489069 cites W1829708015 @default.
- W4288489069 cites W1950448919 @default.
- W4288489069 cites W1985162583 @default.
- W4288489069 cites W1992348175 @default.
- W4288489069 cites W1995003386 @default.
- W4288489069 cites W1999235650 @default.
- W4288489069 cites W2004722837 @default.
- W4288489069 cites W2011427527 @default.
- W4288489069 cites W2023481922 @default.
- W4288489069 cites W2033023829 @default.
- W4288489069 cites W2037736267 @default.
- W4288489069 cites W2064426329 @default.
- W4288489069 cites W2067859468 @default.
- W4288489069 cites W2072656380 @default.
- W4288489069 cites W2082017971 @default.
- W4288489069 cites W2084603524 @default.
- W4288489069 cites W2086882580 @default.
- W4288489069 cites W2096614211 @default.
- W4288489069 cites W2111421329 @default.
- W4288489069 cites W2119985244 @default.
- W4288489069 cites W2128889158 @default.
- W4288489069 cites W2131987313 @default.
- W4288489069 cites W2133357753 @default.
- W4288489069 cites W2134387120 @default.
- W4288489069 cites W2150612673 @default.
- W4288489069 cites W2168933043 @default.
- W4288489069 cites W2341618241 @default.
- W4288489069 cites W2342961125 @default.
- W4288489069 cites W2524753328 @default.
- W4288489069 cites W2597956713 @default.
- W4288489069 cites W2600628374 @default.
- W4288489069 cites W2776257607 @default.
- W4288489069 cites W2803659545 @default.
- W4288489069 cites W2898607807 @default.
- W4288489069 cites W2951291903 @default.
- W4288489069 cites W3003177297 @default.
- W4288489069 cites W3005836461 @default.
- W4288489069 cites W3012283572 @default.
- W4288489069 cites W3028868733 @default.
- W4288489069 cites W3047396241 @default.
- W4288489069 cites W3095682175 @default.
- W4288489069 cites W3112551507 @default.
- W4288489069 cites W3135589467 @default.
- W4288489069 cites W3157583015 @default.
- W4288489069 cites W3172016685 @default.
- W4288489069 cites W3206676628 @default.
- W4288489069 cites W4200478905 @default.
- W4288489069 cites W4211083670 @default.
- W4288489069 cites W4211228105 @default.
- W4288489069 cites W4293380371 @default.
- W4288489069 doi "https://doi.org/10.3389/fimmu.2022.929995" @default.
- W4288489069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35967300" @default.
- W4288489069 hasPublicationYear "2022" @default.
- W4288489069 type Work @default.
- W4288489069 citedByCount "3" @default.
- W4288489069 countsByYear W42884890692022 @default.
- W4288489069 countsByYear W42884890692023 @default.
- W4288489069 crossrefType "journal-article" @default.
- W4288489069 hasAuthorship W4288489069A5011742361 @default.
- W4288489069 hasAuthorship W4288489069A5016258231 @default.
- W4288489069 hasAuthorship W4288489069A5028726117 @default.
- W4288489069 hasAuthorship W4288489069A5034427288 @default.
- W4288489069 hasAuthorship W4288489069A5041818001 @default.
- W4288489069 hasAuthorship W4288489069A5045536586 @default.
- W4288489069 hasAuthorship W4288489069A5050231608 @default.
- W4288489069 hasAuthorship W4288489069A5055789599 @default.
- W4288489069 hasAuthorship W4288489069A5062363608 @default.
- W4288489069 hasAuthorship W4288489069A5066044288 @default.
- W4288489069 hasAuthorship W4288489069A5072787889 @default.
- W4288489069 hasAuthorship W4288489069A5076286462 @default.
- W4288489069 hasAuthorship W4288489069A5081849372 @default.
- W4288489069 hasBestOaLocation W42884890691 @default.
- W4288489069 hasConcept C104317684 @default.
- W4288489069 hasConcept C126322002 @default.
- W4288489069 hasConcept C135763542 @default.
- W4288489069 hasConcept C150194340 @default.
- W4288489069 hasConcept C153209595 @default.
- W4288489069 hasConcept C157410074 @default.
- W4288489069 hasConcept C180754005 @default.
- W4288489069 hasConcept C190727270 @default.
- W4288489069 hasConcept C203014093 @default.