FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288489123> ?p ?o ?g. }

• W4288489123 endingPage "710" @default.
• W4288489123 startingPage "702" @default.
• W4288489123 abstract "Abstract Background PI3K/AKT/mTOR pathway is frequently overactive in esophageal squamous cell carcinoma (ESCC), making it an attractive treatment target. BKM120 is an oral pan-class I PI3K inhibitor with promising activity in several cancers. We prospectively investigated efficacy, safety, and biomarkers of BKM120 in advanced ESCC. We conducted a multicenter phase II study of BKM120 monotherapy in patients with pretreated advanced ESCC. Methods BKM120 (100 mg/day) was administered orally in a 28-day cycle. The primary end point was disease control rate (DCR). Tumor samples for all patients were collected for gene alteration analysis in a comprehensive genomic profiling assay. Results Of 42 patients enrolled, 20 had stable disease and two had confirmed partial response. One ineligible patient was excluded from the primary analysis, which met the primary end point (DCR 51.2%; 95% confidence interval [CI], 35.1–67.1). In the 42 patients, median progression-free survival and overall survival were 2.3 (95% CI 1.8–3.2) and 9.0 (95% CI 6.5–11.4) months, respectively. Common grade 3 or 4 adverse events were rash, anorexia, hyponatremia, and abnormal hepatic function; profiles of these events in this study were similar to those in previous studies of BKM120 monotherapy. No treatment-related deaths occurred. PI3K pathway activation was observed in patients with good clinical response. Conclusions BKM120 monotherapy showed promising efficacy and a manageable toxicity profile even in patients with pretreated advanced ESCC. This study showed the potential target PI3K for ESCC, and further confirmatory trial will be necessary to confirm it. Unique ID issued by UMIN: UMIN 000011217." @default.
• W4288489123 created "2022-07-29" @default.
• W4288489123 creator A5001115937 @default.
• W4288489123 creator A5018910129 @default.
• W4288489123 creator A5019489630 @default.
• W4288489123 creator A5024904484 @default.
• W4288489123 creator A5050468802 @default.
• W4288489123 creator A5057386384 @default.
• W4288489123 creator A5067399580 @default.
• W4288489123 creator A5073330859 @default.
• W4288489123 creator A5082685387 @default.
• W4288489123 creator A5082832235 @default.
• W4288489123 creator A5089442498 @default.
• W4288489123 date "2022-07-29" @default.
• W4288489123 modified "2023-09-30" @default.
• W4288489123 title "Phase II study of BKM120 in patients with advanced esophageal squamous cell carcinoma (EPOC1303)" @default.
• W4288489123 cites W1757407923 @default.
• W4288489123 cites W1878554291 @default.
• W4288489123 cites W1992257057 @default.
• W4288489123 cites W2014620054 @default.
• W4288489123 cites W2036362774 @default.
• W4288489123 cites W2045401584 @default.
• W4288489123 cites W2061861156 @default.
• W4288489123 cites W2086924064 @default.
• W4288489123 cites W2088460013 @default.
• W4288489123 cites W2113814947 @default.
• W4288489123 cites W2114048774 @default.
• W4288489123 cites W2114287880 @default.
• W4288489123 cites W2114408324 @default.
• W4288489123 cites W2116435502 @default.
• W4288489123 cites W2116746092 @default.
• W4288489123 cites W2118073504 @default.
• W4288489123 cites W2139712038 @default.
• W4288489123 cites W2144515630 @default.
• W4288489123 cites W2146414563 @default.
• W4288489123 cites W2154871907 @default.
• W4288489123 cites W2163264742 @default.
• W4288489123 cites W2165404212 @default.
• W4288489123 cites W2166559675 @default.
• W4288489123 cites W2238997491 @default.
• W4288489123 cites W2568467328 @default.
• W4288489123 cites W2569704071 @default.
• W4288489123 cites W2570401594 @default.
• W4288489123 cites W2582286477 @default.
• W4288489123 cites W2724177236 @default.
• W4288489123 doi "https://doi.org/10.1007/s10388-022-00928-3" @default.
• W4288489123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35904643" @default.
• W4288489123 hasPublicationYear "2022" @default.
• W4288489123 type Work @default.
• W4288489123 citedByCount "7" @default.
• W4288489123 countsByYear W42884891232022 @default.
• W4288489123 countsByYear W42884891232023 @default.
• W4288489123 crossrefType "journal-article" @default.
• W4288489123 hasAuthorship W4288489123A5001115937 @default.
• W4288489123 hasAuthorship W4288489123A5018910129 @default.
• W4288489123 hasAuthorship W4288489123A5019489630 @default.
• W4288489123 hasAuthorship W4288489123A5024904484 @default.
• W4288489123 hasAuthorship W4288489123A5050468802 @default.
• W4288489123 hasAuthorship W4288489123A5057386384 @default.
• W4288489123 hasAuthorship W4288489123A5067399580 @default.
• W4288489123 hasAuthorship W4288489123A5073330859 @default.
• W4288489123 hasAuthorship W4288489123A5082685387 @default.
• W4288489123 hasAuthorship W4288489123A5082832235 @default.
• W4288489123 hasAuthorship W4288489123A5089442498 @default.
• W4288489123 hasBestOaLocation W42884891231 @default.
• W4288489123 hasConcept C126322002 @default.
• W4288489123 hasConcept C143998085 @default.
• W4288489123 hasConcept C197934379 @default.
• W4288489123 hasConcept C203092338 @default.
• W4288489123 hasConcept C2777546739 @default.
• W4288489123 hasConcept C2778570526 @default.
• W4288489123 hasConcept C2994415158 @default.
• W4288489123 hasConcept C31760486 @default.
• W4288489123 hasConcept C535046627 @default.
• W4288489123 hasConcept C71924100 @default.
• W4288489123 hasConcept C90924648 @default.
• W4288489123 hasConceptScore W4288489123C126322002 @default.
• W4288489123 hasConceptScore W4288489123C143998085 @default.
• W4288489123 hasConceptScore W4288489123C197934379 @default.
• W4288489123 hasConceptScore W4288489123C203092338 @default.
• W4288489123 hasConceptScore W4288489123C2777546739 @default.
• W4288489123 hasConceptScore W4288489123C2778570526 @default.
• W4288489123 hasConceptScore W4288489123C2994415158 @default.
• W4288489123 hasConceptScore W4288489123C31760486 @default.
• W4288489123 hasConceptScore W4288489123C535046627 @default.
• W4288489123 hasConceptScore W4288489123C71924100 @default.
• W4288489123 hasConceptScore W4288489123C90924648 @default.
• W4288489123 hasFunder F4320332736 @default.
• W4288489123 hasIssue "4" @default.
• W4288489123 hasLocation W42884891231 @default.
• W4288489123 hasLocation W42884891232 @default.
• W4288489123 hasLocation W42884891233 @default.
• W4288489123 hasOpenAccess W4288489123 @default.
• W4288489123 hasPrimaryLocation W42884891231 @default.
• W4288489123 hasRelatedWork W1608269846 @default.
• W4288489123 hasRelatedWork W1993604070 @default.
• W4288489123 hasRelatedWork W2046199264 @default.
• W4288489123 hasRelatedWork W2518309888 @default.

• next