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- W4288514578 abstract "Mpox virus is an emergent human pathogen. While it is less lethal than smallpox, it can still cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with activity against mpox and other orthopoxviruses: cidofovir, brincidofovir, and tecovirimat. Cidofovir, and its prodrug brincidofovir, are inhibitors of DNA replication with a broad spectrum of activity against multiple families of double-stranded DNA viruses. Tecovirimat has more specific activity against orthopoxviruses and inhibits the formation of the extracellular enveloped virus necessary for cell-to-cell transmission. For each agent, we review basic pharmacology, data from animal models, and reported experience in human patients." @default.
- W4288514578 created "2022-07-29" @default.
- W4288514578 creator A5041781576 @default.
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- W4288514578 date "2022-07-29" @default.
- W4288514578 modified "2023-10-14" @default.
- W4288514578 title "Antivirals With Activity Against Mpox: A Clinically Oriented Review" @default.
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- W4288514578 doi "https://doi.org/10.1093/cid/ciac622" @default.
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