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- W4288535656 abstract "Abstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect of nano-magnetite on the reproductive health of female Wistar rats. Twenty-one adult female rats were divided into three groups: Group 1 served as the control group, Group 2 received a low dose of 5 mg/kg of nano-magnetite, and Group 3 received a high dose of 10 mg/kg of nano-magnetite. For 30 days, rats were intraperitoneally injected three times per week. The main findings Revealed that nano-magnetite did not induce a change in body weight or absolute as well as relative reproductive organs weight. Nano-magnetite nanoparticles influenced the reproductive serum hormone levels as well as imbalanced the ovarian and uterine malondialdehyde and total antioxidant activity. After nano-magnetite nanoparticle injection, the histopathological examination revealed apoptosis of granulosa cells of various types of follicles, degenerated corpora lutea, congested blood vessels, and uterine epithelial cells of uterine tissue showed a high level of apoptosis and inflammation. Immunohistochemistry studies demonstrated a significant increase in activated caspase-3 following nano-magnetite injection, indicating an increase in cell apoptosis. Conclusion This study demonstrated the negative effect of magnetite nanoparticle on reproductive health and increased the likelihood of infertility." @default.
- W4288535656 created "2022-07-29" @default.
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- W4288535656 date "2022-07-29" @default.
- W4288535656 modified "2023-09-26" @default.
- W4288535656 title "Assessment of nano-iron particles impact on the reproductive health of female Wistar rats" @default.
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- W4288535656 doi "https://doi.org/10.1186/s43088-022-00274-4" @default.
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