Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288634125> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W4288634125 abstract "Langerhans Cell Histiocytosis (LCH) is a rare disease involving the occurrence of disturbances in the mitogene-activated kinases pathway (MAPK). At present, it is known that the appearance of such disorders is usually connected with a more aggressive form of the disease, more frequently resistant to conventional chemotherapy, as well as characterised by a higher probability of relapse and progression. Since recently, it has been possible to apply BRAF inhibitors in the treatment of LCH patients, however, there are no clear guidelines regarding the criteria for implementing this type of therapy. There are very little literature data as to the safety of using such formulations among juvenile patients. In this paper we present a girl with severe Langerhans Cell Histiocytosis, not responding to conventional treatment, who only after adding vemurafenib achieved a regression of symptoms. This case shows the necessity to expand the diagnostics with molecular tests and the possibility of applying targeted treatment for patients of this kind." @default.
- W4288634125 created "2022-07-30" @default.
- W4288634125 creator A5002495276 @default.
- W4288634125 creator A5041527330 @default.
- W4288634125 creator A5065890972 @default.
- W4288634125 date "2019-01-14" @default.
- W4288634125 modified "2023-09-29" @default.
- W4288634125 title "[Vemurafenib in refractory langerhans histiocytosis]." @default.
- W4288634125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30636236" @default.
- W4288634125 hasPublicationYear "2019" @default.
- W4288634125 type Work @default.
- W4288634125 citedByCount "0" @default.
- W4288634125 crossrefType "journal-article" @default.
- W4288634125 hasAuthorship W4288634125A5002495276 @default.
- W4288634125 hasAuthorship W4288634125A5041527330 @default.
- W4288634125 hasAuthorship W4288634125A5065890972 @default.
- W4288634125 hasConcept C142424586 @default.
- W4288634125 hasConcept C142724271 @default.
- W4288634125 hasConcept C159985019 @default.
- W4288634125 hasConcept C16005928 @default.
- W4288634125 hasConcept C192562407 @default.
- W4288634125 hasConcept C2776131300 @default.
- W4288634125 hasConcept C2777484599 @default.
- W4288634125 hasConcept C2777658100 @default.
- W4288634125 hasConcept C2779134260 @default.
- W4288634125 hasConcept C2780174970 @default.
- W4288634125 hasConcept C2994587330 @default.
- W4288634125 hasConcept C502942594 @default.
- W4288634125 hasConcept C71924100 @default.
- W4288634125 hasConceptScore W4288634125C142424586 @default.
- W4288634125 hasConceptScore W4288634125C142724271 @default.
- W4288634125 hasConceptScore W4288634125C159985019 @default.
- W4288634125 hasConceptScore W4288634125C16005928 @default.
- W4288634125 hasConceptScore W4288634125C192562407 @default.
- W4288634125 hasConceptScore W4288634125C2776131300 @default.
- W4288634125 hasConceptScore W4288634125C2777484599 @default.
- W4288634125 hasConceptScore W4288634125C2777658100 @default.
- W4288634125 hasConceptScore W4288634125C2779134260 @default.
- W4288634125 hasConceptScore W4288634125C2780174970 @default.
- W4288634125 hasConceptScore W4288634125C2994587330 @default.
- W4288634125 hasConceptScore W4288634125C502942594 @default.
- W4288634125 hasConceptScore W4288634125C71924100 @default.
- W4288634125 hasLocation W42886341251 @default.
- W4288634125 hasOpenAccess W4288634125 @default.
- W4288634125 hasPrimaryLocation W42886341251 @default.
- W4288634125 isParatext "false" @default.
- W4288634125 isRetracted "false" @default.
- W4288634125 workType "article" @default.