FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288700769> ?p ?o ?g. }

• W4288700769 endingPage "725" @default.
• W4288700769 startingPage "715" @default.
• W4288700769 abstract "The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony-stimulating factor (G-CSF) is a growth factor that enhances the proliferation, differentiation, and survival of hematopoietic progenitor cells. In the present study, we aimed to investigate the effects of G-CSF in a maternal immune activation-induced autism model.Sixteen female and six male Wistar adult rats were included in the study. After 21 days, 48 littermates (eight male controls, eight female controls, 16 male lipopolysaccharide [LPS]-exposed rats, and 16 female LPS-exposed rats) were divided into groups. Sixteen male LPS-exposed and 16 female LPS-exposed rats were divided into saline and G-CSF treatment groups.In male rats, the LPS-exposed group was found to have significantly higher levels of TNF-α, IL-2, and IL-17 than the LPS-exposed G-CSF group. Levels of nerve growth factor, brain PSD-95, and brain GAD67 were higher in the LPS-exposed G-CSF group than in the LPS-exposed group in male rats. In female rats, brain NGF levels were similar between groups. There was no difference between groups in terms of brain GAD 67 levels. Brain PSD-95 levels were higher in the control group than in both the LPS-exposed and LPS-exposed G-CSF groups in female rats. Both neuronal CA1 and neuronal CA2 levels were lower, and the GFAP immunostaining index (CA1) and GFAP immunostaining index (CA3) were higher in the LPS-exposed group than in the LPS-exposed G-CSF group in male rats. However, neuronal count CA1 and neuronal count CA3 values were found to be similar between groups in female rats.The present research is the first to demonstrate the beneficial effects of G-CSF on core symptoms of ASD experimentally depending on male sex. G-CSF can be a good candidate for ameliorating the core symptoms of ASD without serious side effects in males." @default.
• W4288700769 created "2022-07-30" @default.
• W4288700769 creator A5046182096 @default.
• W4288700769 creator A5046512904 @default.
• W4288700769 creator A5071466971 @default.
• W4288700769 creator A5073940882 @default.
• W4288700769 creator A5084625212 @default.
• W4288700769 creator A5089355925 @default.
• W4288700769 date "2022-08-12" @default.
• W4288700769 modified "2023-10-04" @default.
• W4288700769 title "Granulocyte colony‐stimulating factor has a sex‐dependent positive effect in the maternal immune activation‐induced autism model" @default.
• W4288700769 cites W1580227419 @default.
• W4288700769 cites W1785382835 @default.
• W4288700769 cites W1965350320 @default.
• W4288700769 cites W1977601515 @default.
• W4288700769 cites W1981231759 @default.
• W4288700769 cites W1996087940 @default.
• W4288700769 cites W2006376003 @default.
• W4288700769 cites W2013263136 @default.
• W4288700769 cites W2016712906 @default.
• W4288700769 cites W2017826413 @default.
• W4288700769 cites W2023962370 @default.
• W4288700769 cites W2028803746 @default.
• W4288700769 cites W2029491035 @default.
• W4288700769 cites W2030299359 @default.
• W4288700769 cites W2041442674 @default.
• W4288700769 cites W2050437768 @default.
• W4288700769 cites W2061379575 @default.
• W4288700769 cites W2089224748 @default.
• W4288700769 cites W2092931973 @default.
• W4288700769 cites W2109992632 @default.
• W4288700769 cites W2115856407 @default.
• W4288700769 cites W2118279984 @default.
• W4288700769 cites W2119665388 @default.
• W4288700769 cites W2142631525 @default.
• W4288700769 cites W2167149414 @default.
• W4288700769 cites W2253802357 @default.
• W4288700769 cites W2279054921 @default.
• W4288700769 cites W2344874345 @default.
• W4288700769 cites W2471100961 @default.
• W4288700769 cites W2529708574 @default.
• W4288700769 cites W2550245877 @default.
• W4288700769 cites W2580956661 @default.
• W4288700769 cites W2735327398 @default.
• W4288700769 cites W2759793327 @default.
• W4288700769 cites W2766952563 @default.
• W4288700769 cites W2888826705 @default.
• W4288700769 cites W2897795078 @default.
• W4288700769 cites W2921188258 @default.
• W4288700769 cites W2955807832 @default.
• W4288700769 cites W3005174885 @default.
• W4288700769 cites W3014352885 @default.
• W4288700769 cites W3023295472 @default.
• W4288700769 cites W3047030051 @default.
• W4288700769 cites W3123645172 @default.
• W4288700769 cites W3129176095 @default.
• W4288700769 cites W3184848057 @default.
• W4288700769 cites W3210417599 @default.
• W4288700769 cites W4200492588 @default.
• W4288700769 cites W4206352253 @default.
• W4288700769 cites W4247665917 @default.
• W4288700769 doi "https://doi.org/10.1002/jdn.10221" @default.
• W4288700769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35904498" @default.
• W4288700769 hasPublicationYear "2022" @default.
• W4288700769 type Work @default.
• W4288700769 citedByCount "6" @default.
• W4288700769 countsByYear W42887007692022 @default.
• W4288700769 countsByYear W42887007692023 @default.
• W4288700769 crossrefType "journal-article" @default.
• W4288700769 hasAuthorship W4288700769A5046182096 @default.
• W4288700769 hasAuthorship W4288700769A5046512904 @default.
• W4288700769 hasAuthorship W4288700769A5071466971 @default.
• W4288700769 hasAuthorship W4288700769A5073940882 @default.
• W4288700769 hasAuthorship W4288700769A5084625212 @default.
• W4288700769 hasAuthorship W4288700769A5089355925 @default.
• W4288700769 hasBestOaLocation W42887007691 @default.
• W4288700769 hasConcept C109159458 @default.
• W4288700769 hasConcept C126322002 @default.
• W4288700769 hasConcept C134018914 @default.
• W4288700769 hasConcept C170493617 @default.
• W4288700769 hasConcept C204232928 @default.
• W4288700769 hasConcept C2776694085 @default.
• W4288700769 hasConcept C2777767877 @default.
• W4288700769 hasConcept C2778423431 @default.
• W4288700769 hasConcept C2778754761 @default.
• W4288700769 hasConcept C2779958370 @default.
• W4288700769 hasConcept C28328180 @default.
• W4288700769 hasConcept C4224716 @default.
• W4288700769 hasConcept C54355233 @default.
• W4288700769 hasConcept C71924100 @default.
• W4288700769 hasConcept C86803240 @default.
• W4288700769 hasConceptScore W4288700769C109159458 @default.
• W4288700769 hasConceptScore W4288700769C126322002 @default.
• W4288700769 hasConceptScore W4288700769C134018914 @default.
• W4288700769 hasConceptScore W4288700769C170493617 @default.
• W4288700769 hasConceptScore W4288700769C204232928 @default.
• W4288700769 hasConceptScore W4288700769C2776694085 @default.
• W4288700769 hasConceptScore W4288700769C2777767877 @default.

• next