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- W4288704008 abstract "Abstract Hepatocellular carcinoma has become one of the most shared cancers in the whole world because of its high morbidity, poor survival rate and low recovery rate. Especially in China, hepatocellular carcinoma has been regarded as one of the most malignant cancers. With the exploration of tumor diseases and the development of bioinformatics over the years, lncRNAs have been found to play a direct or indirect regulatory role in tumorigenesis and tumor development, which brings a new direction for the treatment of tumors. Previous studies had investigated that DIO3 opposite strand upstream RNA(DIO3OS) played a promoting role in the occurrence and development of thyroid carcinoma and uterine corpus endometrial carcinoma. However, research focusing on the role of DIO3OS in hepatocellular carcinoma is still uncleared. We found that low DIO3OS level often predicts poor prognosis in patients with hepatocellular carcinoma. In addition, there was significant correlation between different immune cells and their immune markers and DIO3OS. Our results suggest that DIO3OS can be used as an effective biomarker in the diagnosis and prognosis of hepatocellular carcinoma, affecting the development of hepatocellular carcinoma by influencing tumor immune cell infiltration." @default.
- W4288704008 created "2022-07-30" @default.
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- W4288704008 date "2022-07-29" @default.
- W4288704008 modified "2023-10-18" @default.
- W4288704008 title "Decreased DIO3OS expression predicts poor prognosis in hepatocellular carcinoma and is associated with immune infiltration" @default.
- W4288704008 doi "https://doi.org/10.21203/rs.3.rs-1884978/v1" @default.
- W4288704008 hasPublicationYear "2022" @default.
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