FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288710648> ?p ?o ?g. }

• W4288710648 endingPage "661" @default.
• W4288710648 startingPage "651" @default.
• W4288710648 abstract "Background: Blinding is a cornerstone of trial methodology. Prior work indicates participant-perceived assignment may be associated with trial outcomes. Less is known about how perception changes over time and if this is associated with outcomes.Objectives: To evaluate if participants change their perception of assignment over time in a blinded trial, and if perception is associated with different types of patient-reported outcomes (PROs).Methods: This was a secondary analysis of data from the Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment (ACCENT) trial, which evaluated the efficacy of N-acetylcysteine (NAC) relative to placebo for treating cannabis use disorder. Participants (N = 234; 164 men, 70 women) were asked at weeks 5 and 9 what treatment (placebo or NAC) they believed they were receiving. We included PROs proximal (cannabis-associated problems, craving) and distal (anxiety) to the intervention. Analysis was by multiple linear regression and mixed models.Results: Approximately 20% of participants in both arms changed their perception over time. Relative to participants who consistently perceived assignment to placebo, participants who consistently perceived assignment to NAC did not always have comparatively better average scores (coefficient −3.3 [95% CI: −7.0, 0.5]). In some analyses, participants who switched to guessing NAC from placebo had comparatively better average scores (coefficient −3.0 [95% CI: −9.3, 3.4]), but this was inconsistent across outcomes or strata defined by actual assignment or guess accuracy.Conclusion: The study suggests that the proportion of individuals who switch their perception over time is modest. However, this group may influence the estimates of intervention effects on some PROs." @default.
• W4288710648 created "2022-07-30" @default.
• W4288710648 creator A5004513163 @default.
• W4288710648 creator A5010221662 @default.
• W4288710648 creator A5059810022 @default.
• W4288710648 creator A5080669075 @default.
• W4288710648 date "2022-07-29" @default.
• W4288710648 modified "2023-09-27" @default.
• W4288710648 title "Assessment of patient perception of treatment assignment and patient-reported outcomes in a cannabis use disorder trial" @default.
• W4288710648 cites W1549371580 @default.
• W4288710648 cites W1951724000 @default.
• W4288710648 cites W1964502734 @default.
• W4288710648 cites W1970318981 @default.
• W4288710648 cites W1975162716 @default.
• W4288710648 cites W1982265975 @default.
• W4288710648 cites W1982517400 @default.
• W4288710648 cites W2000366380 @default.
• W4288710648 cites W2001253512 @default.
• W4288710648 cites W2006062215 @default.
• W4288710648 cites W2029361694 @default.
• W4288710648 cites W2031158571 @default.
• W4288710648 cites W2032541700 @default.
• W4288710648 cites W2049627236 @default.
• W4288710648 cites W2063989983 @default.
• W4288710648 cites W2078668847 @default.
• W4288710648 cites W2081859324 @default.
• W4288710648 cites W2098923148 @default.
• W4288710648 cites W2112305964 @default.
• W4288710648 cites W2113557608 @default.
• W4288710648 cites W2122666323 @default.
• W4288710648 cites W2125292138 @default.
• W4288710648 cites W2125478133 @default.
• W4288710648 cites W2125763669 @default.
• W4288710648 cites W2133101328 @default.
• W4288710648 cites W2138153168 @default.
• W4288710648 cites W2156047116 @default.
• W4288710648 cites W2156980408 @default.
• W4288710648 cites W2166281097 @default.
• W4288710648 cites W2254980524 @default.
• W4288710648 cites W2305731881 @default.
• W4288710648 cites W2325063727 @default.
• W4288710648 cites W2380126174 @default.
• W4288710648 cites W2520689516 @default.
• W4288710648 cites W2523715715 @default.
• W4288710648 cites W2561777796 @default.
• W4288710648 cites W2624100118 @default.
• W4288710648 cites W2739905229 @default.
• W4288710648 cites W2792994495 @default.
• W4288710648 cites W2805786630 @default.
• W4288710648 cites W2891609623 @default.
• W4288710648 cites W2984436214 @default.
• W4288710648 cites W3001993019 @default.
• W4288710648 cites W3133913092 @default.
• W4288710648 cites W3138824623 @default.
• W4288710648 cites W3211707125 @default.
• W4288710648 cites W1968350513 @default.
• W4288710648 doi "https://doi.org/10.1080/00952990.2022.2097918" @default.
• W4288710648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35904459" @default.
• W4288710648 hasPublicationYear "2022" @default.
• W4288710648 type Work @default.
• W4288710648 citedByCount "0" @default.
• W4288710648 crossrefType "journal-article" @default.
• W4288710648 hasAuthorship W4288710648A5004513163 @default.
• W4288710648 hasAuthorship W4288710648A5010221662 @default.
• W4288710648 hasAuthorship W4288710648A5059810022 @default.
• W4288710648 hasAuthorship W4288710648A5080669075 @default.
• W4288710648 hasConcept C118552586 @default.
• W4288710648 hasConcept C126322002 @default.
• W4288710648 hasConcept C142724271 @default.
• W4288710648 hasConcept C15744967 @default.
• W4288710648 hasConcept C168563851 @default.
• W4288710648 hasConcept C169760540 @default.
• W4288710648 hasConcept C1862650 @default.
• W4288710648 hasConcept C204787440 @default.
• W4288710648 hasConcept C26760741 @default.
• W4288710648 hasConcept C27081682 @default.
• W4288710648 hasConcept C2777056318 @default.
• W4288710648 hasConcept C558461103 @default.
• W4288710648 hasConcept C70410870 @default.
• W4288710648 hasConcept C71924100 @default.
• W4288710648 hasConceptScore W4288710648C118552586 @default.
• W4288710648 hasConceptScore W4288710648C126322002 @default.
• W4288710648 hasConceptScore W4288710648C142724271 @default.
• W4288710648 hasConceptScore W4288710648C15744967 @default.
• W4288710648 hasConceptScore W4288710648C168563851 @default.
• W4288710648 hasConceptScore W4288710648C169760540 @default.
• W4288710648 hasConceptScore W4288710648C1862650 @default.
• W4288710648 hasConceptScore W4288710648C204787440 @default.
• W4288710648 hasConceptScore W4288710648C26760741 @default.
• W4288710648 hasConceptScore W4288710648C27081682 @default.
• W4288710648 hasConceptScore W4288710648C2777056318 @default.
• W4288710648 hasConceptScore W4288710648C558461103 @default.
• W4288710648 hasConceptScore W4288710648C70410870 @default.
• W4288710648 hasConceptScore W4288710648C71924100 @default.
• W4288710648 hasIssue "6" @default.
• W4288710648 hasLocation W42887106481 @default.
• W4288710648 hasLocation W42887106482 @default.
• W4288710648 hasOpenAccess W4288710648 @default.

• next