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- W4288713676 abstract "Because of the rich mitochondria and high energy metabolic requirements, excessive oxidative stress generated by ROS is a key pathogenic mechanism in heart disease. SESTRIN2, the well-known antioxidant protein, plays a vital role in diminishing the production and accumulation of ROS, thus sparing cells from oxidative damage. From this new perspective, we first examine SESTRIN2 structure-function relationships; then, we describe how SESTRIN2 expression is regulated under oxidative stress conditions, emphasizing SESTRIN2’s antioxidant mechanism via multiple signal transductions; and finally, we discuss SESTRIN2’s role in a variety of oxidative stress-related cardiac diseases, including age-related heart disease, diabetic cardiomyopathy, ischemia-reperfusion myocardial injury, septic cardiomyopathy, and chronic cardiac insufficiency. The goal of this review is to identify the SESTRIN2 protein as a potential biomarker and new therapy target for oxidative stress-related cardiac diseases." @default.
- W4288713676 created "2022-07-30" @default.
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- W4288713676 date "2022-07-29" @default.
- W4288713676 modified "2023-09-27" @default.
- W4288713676 title "Oxidative Stress-Induced Protein of SESTRIN2 in Cardioprotection Effect" @default.
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- W4288713676 doi "https://doi.org/10.1155/2022/7439878" @default.
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