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• W4288714484 endingPage "14362" @default.
• W4288714484 startingPage "14351" @default.
• W4288714484 abstract "Near-infrared (NIR) fluorophores absorbing maximally in the region beyond 800 nm, i.e., deep-NIR spectral region, are actively sought for biomedical applications. Ideal dyes are bright, nontoxic, photostable, biocompatible, and easily derivatized to introduce functionalities (e.g., for bioconjugation or aqueous solubility). The rational design of such fluorophores remains a major challenge. Silicon-substituted rhodamines have been successful for bioimaging applications in the red spectral region. The longer-wavelength silicon-substituted congeners for the deep-NIR spectral region are unknown to date. We successfully prepared four silicon-substituted bis-benzannulated rhodamine dyes (ESi5a–ESi5d), with an efficient five-step cascade on a gram-scale. Because of the extensive overlapping of their HOMO–LUMO orbitals, ESi5a–ESi5d are highly absorbing (λabs ≈ 865 nm and ε > 105 cm–1 M–1). By restraining both the rotational freedom via annulation and the vibrational freedom via silicon-imparted strain, the fluorochromic scaffold of ESi5 is highly rigid, resulting in an unusually long fluorescence lifetime (τ > 700 ps in CH2Cl2) and a high fluorescence quantum yield (ϕ = 0.14 in CH2Cl2). Their half-lives toward photobleaching are 2 orders of magnitude longer than the current standard (ICG in serum). They are stable in the presence of biorelevant concentration of nucleophiles or reactive oxygen species. They are minimally toxic and readily metabolized. Upon tail vein injection of ESi5a (as an example), the vasculature of a nude mouse was imaged with a high signal-to-background ratio. ESi5 dyes have broad potentials for bioimaging in the deep-NIR spectral region." @default.
• W4288714484 created "2022-07-30" @default.
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• W4288714484 date "2022-07-29" @default.
• W4288714484 modified "2023-10-16" @default.
• W4288714484 title "Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging" @default.
• W4288714484 cites W1510115707 @default.
• W4288714484 cites W1601011934 @default.
• W4288714484 cites W1977871291 @default.
• W4288714484 cites W1982356449 @default.
• W4288714484 cites W1984851754 @default.
• W4288714484 cites W1986578141 @default.
• W4288714484 cites W1988189635 @default.
• W4288714484 cites W1992478967 @default.
• W4288714484 cites W1992769097 @default.
• W4288714484 cites W1995839347 @default.
• W4288714484 cites W2015602487 @default.
• W4288714484 cites W2017294459 @default.
• W4288714484 cites W2019330110 @default.
• W4288714484 cites W2034569847 @default.
• W4288714484 cites W2052384642 @default.
• W4288714484 cites W2053238537 @default.
• W4288714484 cites W2077227369 @default.
• W4288714484 cites W2097538728 @default.
• W4288714484 cites W2108763092 @default.
• W4288714484 cites W2114733818 @default.
• W4288714484 cites W2120007914 @default.
• W4288714484 cites W2121759011 @default.
• W4288714484 cites W2124754011 @default.
• W4288714484 cites W2143981217 @default.
• W4288714484 cites W2148284063 @default.
• W4288714484 cites W2154338418 @default.
• W4288714484 cites W2155802898 @default.
• W4288714484 cites W2163128710 @default.
• W4288714484 cites W2172026540 @default.
• W4288714484 cites W2261575366 @default.
• W4288714484 cites W2277709702 @default.
• W4288714484 cites W2297298097 @default.
• W4288714484 cites W2315759364 @default.
• W4288714484 cites W2321127459 @default.
• W4288714484 cites W2323975021 @default.
• W4288714484 cites W2335370064 @default.
• W4288714484 cites W2490727090 @default.
• W4288714484 cites W2564926487 @default.
• W4288714484 cites W2571534339 @default.
• W4288714484 cites W2585768892 @default.
• W4288714484 cites W2589348410 @default.
• W4288714484 cites W2621348927 @default.
• W4288714484 cites W2777456282 @default.
• W4288714484 cites W2779346725 @default.
• W4288714484 cites W2793078295 @default.
• W4288714484 cites W2800955494 @default.
• W4288714484 cites W2801064209 @default.
• W4288714484 cites W2801493974 @default.
• W4288714484 cites W2802064447 @default.
• W4288714484 cites W2805542742 @default.
• W4288714484 cites W2887281330 @default.
• W4288714484 cites W2899735953 @default.
• W4288714484 cites W2900329460 @default.
• W4288714484 cites W2904906610 @default.
• W4288714484 cites W2907582934 @default.
• W4288714484 cites W2915948896 @default.
• W4288714484 cites W2919109663 @default.
• W4288714484 cites W2922226239 @default.
• W4288714484 cites W2936653243 @default.
• W4288714484 cites W2938526599 @default.
• W4288714484 cites W2949289995 @default.
• W4288714484 cites W2954922020 @default.
• W4288714484 cites W2963748423 @default.
• W4288714484 cites W2967384131 @default.
• W4288714484 cites W2970334092 @default.
• W4288714484 cites W2972686883 @default.
• W4288714484 cites W2975798969 @default.
• W4288714484 cites W2978728724 @default.
• W4288714484 cites W2982947708 @default.
• W4288714484 cites W2992510352 @default.
• W4288714484 cites W2996334262 @default.
• W4288714484 cites W2997170556 @default.
• W4288714484 cites W3000358775 @default.
• W4288714484 cites W3004541675 @default.

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