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• W4288714726 abstract "Transcription regulation is an important mechanism that controls pluripotency and differentiation. Transcription factors dictate cell fate decisions by functioning cooperatively with chromatin regulators. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein regulates the expression of differentiation-associated genes by modulating the chromatin architecture at promoters. We highlight the collaboration of BEND3 with the polycomb repressive complex in coordinating transcription repression and propose a model highlighting the relevance of the BEND3-PRC2 axis in gene regulation and chromatin organization.Abbreviations: BEND3, BANP, E5R and Nac1 domain; rDNA, ribosomal DNA; PRC2, Polycomb Repressive Complex 2; H3K27me3, Histone H3 Lysine 27 methylation; PcG, Polycomb group." @default.
• W4288714726 created "2022-07-30" @default.
• W4288714726 creator A5040045180 @default.
• W4288714726 creator A5090810201 @default.
• W4288714726 date "2022-05-27" @default.
• W4288714726 modified "2023-09-27" @default.
• W4288714726 title "A BEN-domain protein and polycomb complex work coordinately to regulate transcription" @default.
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• W4288714726 doi "https://doi.org/10.1080/21541264.2022.2105128" @default.
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