Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288724237> ?p ?o ?g. }
- W4288724237 abstract "Abstract Liquid biopsy (LB) is a concept that is rapidly gaining ground in the biomedical field. Its concept is largely based on the detection of circulating cell-free DNA (ccfDNA) fragments that are mostly released as small fragments following cell death in various tissues. A small percentage of these fragments are from foreign (nonself) tissues or organisms. In the present work, we applied this concept to mussels, a sentinel species known for its high filtration capacity of seawater. We exploited the capacity of mussels to be used as natural filters to capture environmental DNA fragments of different origins to provide information on the biodiversity of marine coastal ecosystems. Our results showed that hemolymph of mussels contains DNA fragments that varied considerably in size, ranging from 1 to 5 kb. Shotgun sequencing revealed that a significant amount of DNA fragments had a nonself microbial origin. Among these, we found DNA fragments derived from bacteria, archaea, and viruses, including viruses known to infect a variety of hosts that commonly populate coastal marine ecosystems. Taken together, our study shows that the concept of LB applied to mussels provides a rich and yet unexplored source of knowledge regarding the microbial biodiversity of a marine coastal ecosystem." @default.
- W4288724237 created "2022-07-30" @default.
- W4288724237 creator A5000436062 @default.
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- W4288724237 creator A5012008998 @default.
- W4288724237 creator A5017002315 @default.
- W4288724237 date "2022-07-27" @default.
- W4288724237 modified "2023-10-14" @default.
- W4288724237 title "Applying the concept of liquid biopsy to monitor the microbial biodiversity of marine coastal ecosystems" @default.
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- W4288724237 doi "https://doi.org/10.1038/s43705-022-00145-0" @default.
- W4288724237 hasPublicationYear "2022" @default.
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