Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288732549> ?p ?o ?g. }
- W4288732549 abstract "Abstract C-type lectins (CTLs) represent a large family of soluble and membrane-bound proteins which bind calcium dependently via carbohydrate recognition domains (CRDs) to glycan residues presented on the surface of a variety of pathogens. The deconvolution of a cell’s glycan code by CTLs underpins several important physiological processes in mammals such as pathogen neutralization and opsonization, leukocyte trafficking, and the inflammatory response. However, as our knowledge of CTLs has developed it has become apparent that the role of this innate immune family of proteins can be double-edged, where some pathogens have developed approaches to subvert and exploit CTL interactions to promote infection and sustain the pathological state. Equally, CTL interactions with host glycoproteins can contribute to inflammatory diseases such as arthritis and cancer whereby, in certain contexts, they exacerbate inflammation and drive malignant progression. This review discusses the ‘dual agent’ roles of some of the major mammalian CTLs in both resolving and promoting infection, inflammation and inflammatory disease and highlights opportunities and emerging approaches for their therapeutic modulation." @default.
- W4288732549 created "2022-07-30" @default.
- W4288732549 creator A5007250505 @default.
- W4288732549 creator A5054414352 @default.
- W4288732549 date "2022-07-15" @default.
- W4288732549 modified "2023-10-04" @default.
- W4288732549 title "Tinker, tailor, soldier, cell: the role of C-type lectins in the defense and promotion of disease" @default.
- W4288732549 cites W1182461782 @default.
- W4288732549 cites W1486365785 @default.
- W4288732549 cites W1495488294 @default.
- W4288732549 cites W151654830 @default.
- W4288732549 cites W1521864409 @default.
- W4288732549 cites W1554913609 @default.
- W4288732549 cites W1563926425 @default.
- W4288732549 cites W1590773547 @default.
- W4288732549 cites W1600560134 @default.
- W4288732549 cites W1602188248 @default.
- W4288732549 cites W1779052524 @default.
- W4288732549 cites W1892014909 @default.
- W4288732549 cites W1892694123 @default.
- W4288732549 cites W1911746360 @default.
- W4288732549 cites W1914229765 @default.
- W4288732549 cites W1942720838 @default.
- W4288732549 cites W1944352258 @default.
- W4288732549 cites W1963747204 @default.
- W4288732549 cites W1965399166 @default.
- W4288732549 cites W1972305772 @default.
- W4288732549 cites W1972978364 @default.
- W4288732549 cites W1973283944 @default.
- W4288732549 cites W1974182660 @default.
- W4288732549 cites W1976444953 @default.
- W4288732549 cites W1977510035 @default.
- W4288732549 cites W1979921127 @default.
- W4288732549 cites W1981971084 @default.
- W4288732549 cites W1984469505 @default.
- W4288732549 cites W1988536357 @default.
- W4288732549 cites W1992939453 @default.
- W4288732549 cites W1999369799 @default.
- W4288732549 cites W2001139664 @default.
- W4288732549 cites W2002439557 @default.
- W4288732549 cites W2003996592 @default.
- W4288732549 cites W2012657759 @default.
- W4288732549 cites W2015986985 @default.
- W4288732549 cites W2016475905 @default.
- W4288732549 cites W2019181599 @default.
- W4288732549 cites W2023567662 @default.
- W4288732549 cites W2025195614 @default.
- W4288732549 cites W2027091459 @default.
- W4288732549 cites W2028555435 @default.
- W4288732549 cites W2031039028 @default.
- W4288732549 cites W2031280438 @default.
- W4288732549 cites W2032429373 @default.
- W4288732549 cites W2034527604 @default.
- W4288732549 cites W2036341491 @default.
- W4288732549 cites W2036671521 @default.
- W4288732549 cites W2041042935 @default.
- W4288732549 cites W2045074986 @default.
- W4288732549 cites W2048013672 @default.
- W4288732549 cites W2048215714 @default.
- W4288732549 cites W2049698725 @default.
- W4288732549 cites W2050848743 @default.
- W4288732549 cites W2053863608 @default.
- W4288732549 cites W2054199100 @default.
- W4288732549 cites W2063157332 @default.
- W4288732549 cites W2063541126 @default.
- W4288732549 cites W2063885657 @default.
- W4288732549 cites W2067957598 @default.
- W4288732549 cites W2070618971 @default.
- W4288732549 cites W2072426213 @default.
- W4288732549 cites W2072875291 @default.
- W4288732549 cites W2073503811 @default.
- W4288732549 cites W2074548201 @default.
- W4288732549 cites W2075847325 @default.
- W4288732549 cites W2077859091 @default.
- W4288732549 cites W2078890343 @default.
- W4288732549 cites W2082039219 @default.
- W4288732549 cites W2082081313 @default.
- W4288732549 cites W2086049041 @default.
- W4288732549 cites W2086155380 @default.
- W4288732549 cites W2086744153 @default.
- W4288732549 cites W2089298835 @default.
- W4288732549 cites W2090087004 @default.
- W4288732549 cites W2090973041 @default.
- W4288732549 cites W2091876865 @default.
- W4288732549 cites W2092946137 @default.
- W4288732549 cites W2093329141 @default.
- W4288732549 cites W2093551242 @default.
- W4288732549 cites W2099443558 @default.
- W4288732549 cites W2100518445 @default.
- W4288732549 cites W2101970489 @default.
- W4288732549 cites W2103911618 @default.
- W4288732549 cites W2105755414 @default.
- W4288732549 cites W2110673949 @default.
- W4288732549 cites W2112164142 @default.
- W4288732549 cites W2113038626 @default.
- W4288732549 cites W2116005538 @default.
- W4288732549 cites W2116206771 @default.
- W4288732549 cites W2117098821 @default.
- W4288732549 cites W2117845120 @default.
- W4288732549 cites W2121783932 @default.