Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288736974> ?p ?o ?g. }
- W4288736974 endingPage "179" @default.
- W4288736974 startingPage "170" @default.
- W4288736974 abstract "Neurogenesis is an essential, lifelong process during which neural stem cells generate new neurons within the hippocampus, a center for learning, memory, and mood control. Neural stem cells are vulnerable to environmental insults spanning from chronic stress to radiation. These insults reduce their numbers and diminish neurogenesis, leading to memory decline, anxiety, and depression. Preserving neural stem cells could thus help prevent these neurogenesis-associated pathologies, an outcome particularly important for long-term space missions where environmental exposure to radiation is significantly higher than on Earth. Multiple developments, from mechanistic discoveries of radiation injury on hippocampal neurogenesis to new platforms for the development of selective, specific, effective, and safe small molecules as neurogenesis-protective agents hold great promise to minimize radiation damage on neurogenesis. In this review, we summarize the effects of space-like radiation on hippocampal neurogenesis. We then focus on current advances in drug discovery and development and discuss the nuclear receptor TLX/NR2E1 (oleic acid receptor) as an example of a neurogenic target that might rescue neurogenesis following radiation." @default.
- W4288736974 created "2022-07-30" @default.
- W4288736974 creator A5001737201 @default.
- W4288736974 creator A5010322049 @default.
- W4288736974 creator A5022531075 @default.
- W4288736974 creator A5037851639 @default.
- W4288736974 creator A5052523510 @default.
- W4288736974 creator A5059894322 @default.
- W4288736974 creator A5067640100 @default.
- W4288736974 creator A5080511265 @default.
- W4288736974 date "2022-11-01" @default.
- W4288736974 modified "2023-10-18" @default.
- W4288736974 title "Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects" @default.
- W4288736974 cites W1482674003 @default.
- W4288736974 cites W1581458838 @default.
- W4288736974 cites W1632803295 @default.
- W4288736974 cites W1780106974 @default.
- W4288736974 cites W1800123942 @default.
- W4288736974 cites W1815206142 @default.
- W4288736974 cites W1828558002 @default.
- W4288736974 cites W1874466506 @default.
- W4288736974 cites W1923055195 @default.
- W4288736974 cites W1959902108 @default.
- W4288736974 cites W1961932368 @default.
- W4288736974 cites W1963724707 @default.
- W4288736974 cites W1963940970 @default.
- W4288736974 cites W1971695360 @default.
- W4288736974 cites W1975432831 @default.
- W4288736974 cites W1975528261 @default.
- W4288736974 cites W1977694851 @default.
- W4288736974 cites W1979762984 @default.
- W4288736974 cites W1980576528 @default.
- W4288736974 cites W1981829804 @default.
- W4288736974 cites W1982312504 @default.
- W4288736974 cites W1984014309 @default.
- W4288736974 cites W1984703718 @default.
- W4288736974 cites W1989838140 @default.
- W4288736974 cites W1994853971 @default.
- W4288736974 cites W1995188451 @default.
- W4288736974 cites W1996482741 @default.
- W4288736974 cites W1999146187 @default.
- W4288736974 cites W1999447220 @default.
- W4288736974 cites W2001675158 @default.
- W4288736974 cites W2001975498 @default.
- W4288736974 cites W2002161951 @default.
- W4288736974 cites W2010053974 @default.
- W4288736974 cites W2011580597 @default.
- W4288736974 cites W2013943089 @default.
- W4288736974 cites W2014099101 @default.
- W4288736974 cites W2014559245 @default.
- W4288736974 cites W2016500868 @default.
- W4288736974 cites W2017773565 @default.
- W4288736974 cites W2018934769 @default.
- W4288736974 cites W2021640456 @default.
- W4288736974 cites W2022686017 @default.
- W4288736974 cites W2023295081 @default.
- W4288736974 cites W2025828736 @default.
- W4288736974 cites W2026393786 @default.
- W4288736974 cites W2028085044 @default.
- W4288736974 cites W2029819292 @default.
- W4288736974 cites W2030212579 @default.
- W4288736974 cites W2030772288 @default.
- W4288736974 cites W2031441006 @default.
- W4288736974 cites W2031482209 @default.
- W4288736974 cites W2031531997 @default.
- W4288736974 cites W2035904498 @default.
- W4288736974 cites W2042996394 @default.
- W4288736974 cites W2043722484 @default.
- W4288736974 cites W2044103334 @default.
- W4288736974 cites W2045871368 @default.
- W4288736974 cites W2046006021 @default.
- W4288736974 cites W2046683077 @default.
- W4288736974 cites W2046813714 @default.
- W4288736974 cites W2051021067 @default.
- W4288736974 cites W2051173215 @default.
- W4288736974 cites W2051393353 @default.
- W4288736974 cites W2051411576 @default.
- W4288736974 cites W2053326179 @default.
- W4288736974 cites W2054851504 @default.
- W4288736974 cites W2058582505 @default.
- W4288736974 cites W2059580306 @default.
- W4288736974 cites W2059580803 @default.
- W4288736974 cites W2060011143 @default.
- W4288736974 cites W2060709606 @default.
- W4288736974 cites W2061071633 @default.
- W4288736974 cites W2061111257 @default.
- W4288736974 cites W2061668810 @default.
- W4288736974 cites W2064443937 @default.
- W4288736974 cites W2067856703 @default.
- W4288736974 cites W2068243669 @default.
- W4288736974 cites W2069785065 @default.
- W4288736974 cites W2077722738 @default.
- W4288736974 cites W2078977128 @default.
- W4288736974 cites W2079156156 @default.
- W4288736974 cites W2080532650 @default.
- W4288736974 cites W2081700879 @default.
- W4288736974 cites W2084230759 @default.
- W4288736974 cites W2084777187 @default.